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Myh9 myosin, heavy polypeptide 9, non-muscle [ Mus musculus (house mouse) ]

Gene ID: 17886, updated on 2-Apr-2024

Summary

Official Symbol
Myh9provided by MGI
Official Full Name
myosin, heavy polypeptide 9, non-muscleprovided by MGI
Primary source
MGI:MGI:107717
See related
Ensembl:ENSMUSG00000022443 AllianceGenome:MGI:107717
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fltn; Myhn1; Myhn-1; TU72.6; NMHCIIA; NMMHC-A; NMHC II-A; NMMHC-IIA
Summary
Enables protein domain specific binding activity. Involved in several processes, including cortical granule exocytosis; negative regulation of actin filament severing; and positive regulation of protein processing in phagocytic vesicle. Acts upstream of or within several processes, including establishment of T cell polarity; microtubule cytoskeleton organization; and myoblast fusion. Located in several cellular components, including cortical granule; cytoskeleton; and immunological synapse. Part of myosin II complex. Colocalizes with focal adhesion. Is expressed in several structures, including alimentary system; early embryo; future spinal cord; heart and pericardium; and sensory organ. Used to study MYH-9 related disease. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal disease; and orofacial cleft. Orthologous to human MYH9 (myosin heavy chain 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 64.5), spleen adult (RPKM 64.1) and 27 other tissues See more
Orthologs
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Genomic context

See Myh9 in Genome Data Viewer
Location:
15 E1; 15 36.81 cM
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (77644788..77726315, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (77760585..77842175, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene apolipoprotein L 9b Neighboring gene apolipoprotein L 8 Neighboring gene VISTA enhancer mm1644 Neighboring gene STARR-seq mESC enhancer starr_39115 Neighboring gene STARR-seq mESC enhancer starr_39117 Neighboring gene STARR-positive B cell enhancer ABC_E8905 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:77664820-77665003 Neighboring gene STARR-positive B cell enhancer ABC_E140 Neighboring gene STARR-positive B cell enhancer ABC_E5493 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:77680033-77680254 Neighboring gene STARR-seq mESC enhancer starr_39123 Neighboring gene predicted gene, 22107 Neighboring gene predicted gene, 53901 Neighboring gene STARR-seq mESC enhancer starr_39132 Neighboring gene STARR-positive B cell enhancer ABC_E479 Neighboring gene thioredoxin 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • E030044M24Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
 
enables follicle-stimulating hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microfilament motor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-membrane adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament bundle distribution ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in actin filament capping IDA
Inferred from Direct Assay
more info
PubMed 
NOT involved_in actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within actin filament-based movement ISO
Inferred from Sequence Orthology
more info
 
involved_in actomyosin structure organization ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cortical granule exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytokinetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in endodermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of T cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of meiotic spindle localization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in follicle-stimulating hormone signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lysosome localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within meiotic spindle organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myoblast fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of actin filament severing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of actin filament severing ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in plasma membrane repair ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inositol trisphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein processing in phagocytic vesicle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulated exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin filament organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of plasma membrane repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within uropod organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in actomyosin ISO
Inferred from Sequence Orthology
more info
 
located_in actomyosin contractile ring ISO
Inferred from Sequence Orthology
more info
 
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in brush border IDA
Inferred from Direct Assay
more info
PubMed 
located_in brush border ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
 
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
 
located_in cortical cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cortical granule IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with endosome ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
located_in immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of myosin II complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of myosin II complex ISO
Inferred from Sequence Orthology
more info
 
located_in myosin II filament ISO
Inferred from Sequence Orthology
more info
 
part_of myosin complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in stress fiber IDA
Inferred from Direct Assay
more info
PubMed 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
 
located_in uropod IDA
Inferred from Direct Assay
more info
PubMed 
located_in uropod ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
myosin-9
Names
cellular myosin heavy chain, type A
flectin
myosin IIA
myosin heavy chain IX
non-muscle myosin heavy chain IIa

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022410.4NP_071855.2  myosin-9

    See identical proteins and their annotated locations for NP_071855.2

    Status: VALIDATED

    Source sequence(s)
    AL583886
    Consensus CDS
    CCDS27605.1
    UniProtKB/Swiss-Prot
    Q3UHT9, Q3UHU4, Q6KAN6, Q811I2, Q8VDD5
    Related
    ENSMUSP00000016771.7, ENSMUST00000016771.13
    Conserved Domains (8) summary
    cl22853
    Location:95764
    Motor_domain; Myosin and Kinesin motor domain
    pfam00063
    Location:83764
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:8421921
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3068
    Myosin_N; Myosin N-terminal SH3-like domain
    cl00240
    Location:12061261
    RRF; Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another round of ...
    cl02376
    Location:16101678
    DUF2390; Protein of unknown function (DUF2390)
    cl15254
    Location:10381149
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl23720
    Location:14801587
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    77644788..77726315 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)