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TRIM37 tripartite motif containing 37 [ Homo sapiens (human) ]

Gene ID: 4591, updated on 7-Oct-2018

Summary

Official Symbol
TRIM37provided by HGNC
Official Full Name
tripartite motif containing 37provided by HGNC
Primary source
HGNC:HGNC:7523
See related
Ensembl:ENSG00000108395 MIM:605073; Vega:OTTHUMG00000179360
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MUL; POB1; TEF3
Summary
This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. [provided by RefSeq, Mar 2016]
Expression
Broad expression in testis (RPKM 19.8), brain (RPKM 14.1) and 23 other tissues See more
Orthologs

Genomic context

See TRIM37 in Genome Data Viewer
Location:
17q22
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (58968010..59106964, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (57059999..57184266, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1E Neighboring gene RNA, U6 small nuclear 518, pseudogene Neighboring gene ribosomal protein S12 pseudogene 30 Neighboring gene RNA, 7SL, cytoplasmic 716, pseudogene Neighboring gene RNA, U2 small nuclear 58, pseudogene Neighboring gene spindle and kinetochore associated complex subunit 2 Neighboring gene microRNA 454

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Mulibrey nanism syndrome
MedGen: C0524582 OMIM: 253250 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Meta-analysis identifies four new loci associated with testicular germ cell tumor.
NHGRI GWA Catalog

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0898

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
tumor necrosis factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
PubMed 
aggresome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM37
Names
RING-B-box-coiled-coil protein
RING-type E3 ubiquitin transferase TRIM37
mulibrey nanism protein
NP_001005207.1
NP_001307916.1
NP_001307917.1
NP_001307918.1
NP_001307919.1
NP_001340011.1
NP_001340012.1
NP_001340013.1
NP_001340014.1
NP_001340015.1
NP_056109.1
XP_005257442.1
XP_011523133.1
XP_011523134.1
XP_011523135.1
XP_011523136.1
XP_011523138.1
XP_016880151.1
XP_016880152.1
XP_016880153.1
XP_016880154.1
XP_016880156.1
XP_016880158.1
XP_016880159.1
XP_016880160.1
XP_016880161.1
XP_016880162.1
XP_024306533.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009298.1 RefSeqGene

    Range
    4942..129268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001005207.4NP_001005207.1  E3 ubiquitin-protein ligase TRIM37 isoform a

    See identical proteins and their annotated locations for NP_001005207.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) and variant 1 encode the same isoform (a).
    Source sequence(s)
    AC099850, AI307801, AK292459, BC036012, DC343932, DC351295
    Consensus CDS
    CCDS45746.1
    UniProtKB/Swiss-Prot
    O94972
    Related
    ENSP00000376785.3, OTTHUMP00000261209, ENST00000393066.7
    Conserved Domains (4) summary
    smart00502
    Location:132254
    BBC; B-Box C-terminal domain
    cd00162
    Location:1558
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd03773
    Location:273406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    pfam00643
    Location:90132
    zf-B_box; B-box zinc finger
  2. NM_001320987.2NP_001307916.1  E3 ubiquitin-protein ligase TRIM37 isoform b

    Status: REVIEWED

    Source sequence(s)
    AB020705, AC099850, AC100832, AI610736, AK294850, DC343932
    Consensus CDS
    CCDS82174.1
    UniProtKB/Swiss-Prot
    O94972
    Related
    ENSP00000376784.2, OTTHUMP00000261212, ENST00000393065.6
    Conserved Domains (3) summary
    smart00502
    Location:98220
    BBC; B-Box C-terminal domain
    cd03773
    Location:239372
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    pfam00643
    Location:5698
    zf-B_box; B-box zinc finger
  3. NM_001320988.2NP_001307917.1  E3 ubiquitin-protein ligase TRIM37 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) and variant 5 encode the same isoform (c).
    Source sequence(s)
    AC005207, AC036154, AC099850, AC100832
    Conserved Domains (4) summary
    smart00502
    Location:132254
    BBC; B-Box C-terminal domain
    cd00162
    Location:1558
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd03773
    Location:273406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    pfam00643
    Location:90132
    zf-B_box; B-box zinc finger
  4. NM_001320989.2NP_001307918.1  E3 ubiquitin-protein ligase TRIM37 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) and variant 4 encode the same isoform (c).
    Source sequence(s)
    AC005207, AC036154, AC099850, AC100832
    Conserved Domains (4) summary
    smart00502
    Location:132254
    BBC; B-Box C-terminal domain
    cd00162
    Location:1558
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd03773
    Location:273406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    pfam00643
    Location:90132
    zf-B_box; B-box zinc finger
  5. NM_001320990.2NP_001307919.1  E3 ubiquitin-protein ligase TRIM37 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC099850, AC100832, AI610736, BX537955, DC343932
    UniProtKB/Swiss-Prot
    O94972
    Conserved Domains (2) summary
    smart00502
    Location:10132
    BBC; B-Box C-terminal domain
    cd03773
    Location:151284
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
  6. NM_001353082.1NP_001340011.1  E3 ubiquitin-protein ligase TRIM37 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC005207, AC036154, AC099850, AC100832
    Conserved Domains (4) summary
    smart00502
    Location:98220
    BBC; B-Box C-terminal domain
    smart00336
    Location:5798
    BBOX; B-Box-type zinc finger
    cd03773
    Location:239372
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    cl17238
    Location:621
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  7. NM_001353083.1NP_001340012.1  E3 ubiquitin-protein ligase TRIM37 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC005207, AC036154, AC099850, AC100832
    Conserved Domains (1) summary
    cd03773
    Location:28161
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
  8. NM_001353084.1NP_001340013.1  E3 ubiquitin-protein ligase TRIM37 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC005207, AC036154, AC099850, AC100832
    Conserved Domains (4) summary
    smart00502
    Location:132254
    BBC; B-Box C-terminal domain
    smart00336
    Location:91132
    BBOX; B-Box-type zinc finger
    cd03773
    Location:273406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    cd16619
    Location:1355
    mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
  9. NM_001353085.1NP_001340014.1  E3 ubiquitin-protein ligase TRIM37 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC005207, AC036154, AC099850, AC100832
    Conserved Domains (2) summary
    cd03773
    Location:119252
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    cl25407
    Location:1100
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
  10. NM_001353086.1NP_001340015.1  E3 ubiquitin-protein ligase TRIM37 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC005207, AC036154, AC099850, AC100832
    Conserved Domains (4) summary
    smart00502
    Location:132254
    BBC; B-Box C-terminal domain
    smart00336
    Location:91132
    BBOX; B-Box-type zinc finger
    cd03773
    Location:270389
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    cd16619
    Location:1355
    mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
  11. NM_015294.5NP_056109.1  E3 ubiquitin-protein ligase TRIM37 isoform a

    See identical proteins and their annotated locations for NP_056109.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same isoform (a).
    Source sequence(s)
    AB020705, AC099850, AK289674, CN388771, DC343932, DC351295
    Consensus CDS
    CCDS32694.1
    UniProtKB/Swiss-Prot
    O94972
    Related
    ENSP00000262294.7, OTTHUMP00000261211, ENST00000262294.11
    Conserved Domains (4) summary
    smart00502
    Location:132254
    BBC; B-Box C-terminal domain
    cd00162
    Location:1558
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd03773
    Location:273406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    pfam00643
    Location:90132
    zf-B_box; B-box zinc finger

RNA

  1. NR_148346.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005207, AC036154, AC099850, AC100832
    Related
    ENST00000577554.5
  2. NR_148347.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005207, AC036154, AC099850, AC100832

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    58968010..59106964 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024663.2XP_016880152.1  E3 ubiquitin-protein ligase TRIM37 isoform X4

  2. XM_017024662.1XP_016880151.1  E3 ubiquitin-protein ligase TRIM37 isoform X2

  3. XM_005257385.1XP_005257442.1  E3 ubiquitin-protein ligase TRIM37 isoform X6

    Conserved Domains (4) summary
    smart00502
    Location:132254
    BBC; B-Box C-terminal domain
    smart00336
    Location:91132
    BBOX; B-Box-type zinc finger
    cd03773
    Location:273406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    cd16619
    Location:1355
    mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
  4. XM_017024667.1XP_016880156.1  E3 ubiquitin-protein ligase TRIM37 isoform X11

    Conserved Domains (4) summary
    smart00502
    Location:132254
    BBC; B-Box C-terminal domain
    smart00336
    Location:91132
    BBOX; B-Box-type zinc finger
    cd03773
    Location:270389
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    cd16619
    Location:1355
    mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
  5. XM_011524832.2XP_011523134.1  E3 ubiquitin-protein ligase TRIM37 isoform X3

    Conserved Domains (4) summary
    smart00502
    Location:132254
    BBC; B-Box C-terminal domain
    cd00162
    Location:1558
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd03773
    Location:273406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    pfam00643
    Location:90132
    zf-B_box; B-box zinc finger
  6. XM_024450765.1XP_024306533.1  E3 ubiquitin-protein ligase TRIM37 isoform X14

    Conserved Domains (2) summary
    cd03773
    Location:119252
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    cl25407
    Location:1100
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
  7. XM_017024665.1XP_016880154.1  E3 ubiquitin-protein ligase TRIM37 isoform X9

  8. XM_011524833.1XP_011523135.1  E3 ubiquitin-protein ligase TRIM37 isoform X5

    Conserved Domains (4) summary
    smart00502
    Location:132254
    BBC; B-Box C-terminal domain
    cd00162
    Location:1558
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd03773
    Location:270389
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    pfam00643
    Location:90132
    zf-B_box; B-box zinc finger
  9. XM_011524836.1XP_011523138.1  E3 ubiquitin-protein ligase TRIM37 isoform X10

    Conserved Domains (4) summary
    smart00502
    Location:132254
    BBC; B-Box C-terminal domain
    cd00162
    Location:1558
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd03773
    Location:273406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    pfam00643
    Location:90132
    zf-B_box; B-box zinc finger
  10. XM_011524831.1XP_011523133.1  E3 ubiquitin-protein ligase TRIM37 isoform X1

    Conserved Domains (4) summary
    smart00502
    Location:132254
    BBC; B-Box C-terminal domain
    cd00162
    Location:1558
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd03773
    Location:273406
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    pfam00643
    Location:90132
    zf-B_box; B-box zinc finger
  11. XM_011524834.1XP_011523136.1  E3 ubiquitin-protein ligase TRIM37 isoform X7

    Conserved Domains (3) summary
    smart00502
    Location:98220
    BBC; B-Box C-terminal domain
    cd03773
    Location:239372
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    pfam00643
    Location:5698
    zf-B_box; B-box zinc finger
  12. XM_017024673.2XP_016880162.1  E3 ubiquitin-protein ligase TRIM37 isoform X17

  13. XM_017024671.2XP_016880160.1  E3 ubiquitin-protein ligase TRIM37 isoform X15

    Conserved Domains (2) summary
    cd03773
    Location:119252
    MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...
    cl25407
    Location:1100
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
  14. XM_017024664.1XP_016880153.1  E3 ubiquitin-protein ligase TRIM37 isoform X8

  15. XM_017024669.2XP_016880158.1  E3 ubiquitin-protein ligase TRIM37 isoform X12

  16. XM_017024672.1XP_016880161.1  E3 ubiquitin-protein ligase TRIM37 isoform X16

  17. XM_017024670.2XP_016880159.1  E3 ubiquitin-protein ligase TRIM37 isoform X13

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