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MUC3A mucin 3A, cell surface associated [ Homo sapiens (human) ]

Gene ID: 4584, updated on 1-Mar-2024

Summary

Official Symbol
MUC3Aprovided by HGNC
Official Full Name
mucin 3A, cell surface associatedprovided by HGNC
Primary source
HGNC:HGNC:7513
See related
Ensembl:ENSG00000169894 MIM:158371; AllianceGenome:HGNC:7513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MUC3; MUC-3A
Summary
The mucin genes encode epithelial glycoproteins, some of which are secreted and some membrane bound. Each of the genes contains at least one large domain of tandemly repeated sequence that encodes the peptide sequence rich in serine and/or threonine residues, which carries most of the O-linked glycosylation (Gendler and Spicer, 1995 [PubMed 7778880]).[supplied by OMIM, Aug 2008]
Annotation information
Annotation category: suggests misassembly
Expression
Biased expression in duodenum (RPKM 17.8), small intestine (RPKM 15.8) and 6 other tissues See more
Orthologs
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Genomic context

See MUC3A in Genome Data Viewer
Location:
7q22.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (100949534..100968347)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (102189627..102215508)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100547166..100611620)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 549, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26394 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100525101-100526058 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100526059-100527015 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100531037-100531538 Neighboring gene ribosomal protein S29 pseudogene 15 Neighboring gene uncharacterized LOC105375431 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:100541229-100541778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100546705-100547685 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100547686-100548665 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:100548721-100549266 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:100551103-100551603 Neighboring gene uncharacterized LOC124900622 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18473 Neighboring gene mucin 12, cell surface associated Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:100640603-100641456 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100641457-100642309 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100658552-100659220 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26396 Neighboring gene Sharpr-MPRA regulatory region 8701 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26397 Neighboring gene MUC12 antisense RNA 1 Neighboring gene mucin 17, cell surface associated Neighboring gene RN7SK pseudogene 54

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
mucin-3A
Names
intestinal mucin
mucin 3, intestinal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005960.2NP_005951.1  mucin-3A precursor

    Status: VALIDATED

    Source sequence(s)
    AB038784, AC254629, BI005786
    Consensus CDS
    CCDS78262.1
    UniProtKB/Swiss-Prot
    A6NP22, O14650, O14651, O43418, O43421, Q02505, Q02506, Q6W763, Q9H3Q7, Q9UKW9, Q9UN93, Q9UN94, Q9UN95
    Related
    ENSP00000368771.5, ENST00000379458.9
    Conserved Domains (2) summary
    cd00055
    Location:29582998
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam01390
    Location:30313115
    SEA; SEA domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    100949534..100968347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    102189627..102215508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)