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MUC3A mucin 3A, cell surface associated [ Homo sapiens (human) ]

Gene ID: 4584, updated on 8-Jul-2021

Summary

Official Symbol
MUC3Aprovided by HGNC
Official Full Name
mucin 3A, cell surface associatedprovided by HGNC
Primary source
HGNC:HGNC:7513
See related
Ensembl:ENSG00000169894 MIM:158371
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MUC3; MUC-3A
Summary
The mucin genes encode epithelial glycoproteins, some of which are secreted and some membrane bound. Each of the genes contains at least one large domain of tandemly repeated sequence that encodes the peptide sequence rich in serine and/or threonine residues, which carries most of the O-linked glycosylation (Gendler and Spicer, 1995 [PubMed 7778880]).[supplied by OMIM, Aug 2008]
Expression
Biased expression in duodenum (RPKM 17.8), small intestine (RPKM 15.8) and 6 other tissues See more
Orthologs
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Genomic context

See MUC3A in Genome Data Viewer
Location:
7q22.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (100949534..100968347)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100547166..100611620)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 549, pseudogene Neighboring gene ribosomal protein S29 pseudogene 15 Neighboring gene uncharacterized LOC105375431 Neighboring gene mucin 12, cell surface associated Neighboring gene MUC12 antisense RNA 1 Neighboring gene mucin 17, cell surface associated Neighboring gene RN7SK pseudogene 54

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in Golgi lumen TAS
Traceable Author Statement
more info
 
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
located_in integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
mucin-3A
Names
intestinal mucin
mucin 3, intestinal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005960.2NP_005951.1  mucin-3A precursor

    Status: VALIDATED

    Source sequence(s)
    AB038784, AC254629, BI005786
    Consensus CDS
    CCDS78262.1
    UniProtKB/Swiss-Prot
    Q02505
    UniProtKB/TrEMBL
    Q9H3Q6
    Related
    ENSP00000368771.5, ENST00000379458.9
    Conserved Domains (2) summary
    cd00055
    Location:29582998
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam01390
    Location:30313115
    SEA; SEA domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    100949534..100968347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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