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MTIF2 mitochondrial translational initiation factor 2 [ Homo sapiens (human) ]

Gene ID: 4528, updated on 21-Dec-2019

Summary

Official Symbol
MTIF2provided by HGNC
Official Full Name
mitochondrial translational initiation factor 2provided by HGNC
Primary source
HGNC:HGNC:7441
See related
Ensembl:ENSG00000085760 MIM:603766
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in colon (RPKM 8.3), thyroid (RPKM 7.3) and 25 other tissues See more
Orthologs

Genomic context

See MTIF2 in Genome Data Viewer
Location:
2p16.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (55235583..55269314, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (55463756..55496384, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374674 Neighboring gene clathrin heavy chain linker domain containing 1 Neighboring gene CDPF1 pseudogene 1 Neighboring gene ribosomal protein S27a Neighboring gene prolyl-tRNA synthetase associated domain containing 1, pseudogene Neighboring gene coiled-coil domain containing 88A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
nucleocapsid gag HIV-1 NC downregulates mitochondrial translational initiation factor 2 in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
ribosomal small subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
 
translation factor activity, RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
mitochondrial translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of translational initiation TAS
Traceable Author Statement
more info
PubMed 
ribosome disassembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
mitochondrion TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
translation initiation factor IF-2, mitochondrial
Names
IF-2mt

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047062.1 RefSeqGene

    Range
    5125..37684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001005369.1NP_001005369.1  translation initiation factor IF-2, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_001005369.1

    Status: REVIEWED

    Source sequence(s)
    AF494407, BC002667, BC064977, BU684812
    Consensus CDS
    CCDS1853.1
    UniProtKB/Swiss-Prot
    P46199
    UniProtKB/TrEMBL
    Q6P1N2
    Conserved Domains (5) summary
    cd01887
    Location:181345
    IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
    COG0532
    Location:176718
    InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
    pfam11987
    Location:515606
    IF-2; Translation-initiation factor 2
    cd03692
    Location:624711
    mtIF2_IVc; C2 subdomain of domain IV in mitochondrial translation initiation factor 2
    cd03702
    Location:354448
    IF2_mtIF2_II; Domain II of bacterial and mitochondrial Initiation Factor 2
  2. NM_001321001.1NP_001307930.1  translation initiation factor IF-2, mitochondrial isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AC012358, AF494407, BU681583, CB961193
    Consensus CDS
    CCDS1853.1
    UniProtKB/Swiss-Prot
    P46199
    Conserved Domains (5) summary
    cd01887
    Location:181345
    IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
    COG0532
    Location:176718
    InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
    pfam11987
    Location:515606
    IF-2; Translation-initiation factor 2
    cd03692
    Location:624711
    mtIF2_IVc; C2 subdomain of domain IV in mitochondrial translation initiation factor 2
    cd03702
    Location:354448
    IF2_mtIF2_II; Domain II of bacterial and mitochondrial Initiation Factor 2
  3. NM_001321002.1NP_001307931.1  translation initiation factor IF-2, mitochondrial isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AC012358, AF494407, BP282053, BU681583, CB961193
    Consensus CDS
    CCDS1853.1
    UniProtKB/Swiss-Prot
    P46199
    Related
    ENSP00000378099.3, ENST00000394600.7
    Conserved Domains (5) summary
    cd01887
    Location:181345
    IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
    COG0532
    Location:176718
    InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
    pfam11987
    Location:515606
    IF-2; Translation-initiation factor 2
    cd03692
    Location:624711
    mtIF2_IVc; C2 subdomain of domain IV in mitochondrial translation initiation factor 2
    cd03702
    Location:354448
    IF2_mtIF2_II; Domain II of bacterial and mitochondrial Initiation Factor 2
  4. NM_001321003.1NP_001307932.1  translation initiation factor IF-2, mitochondrial isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AC012358, AF494407, BC067352, BU681583, CB961193
    Consensus CDS
    CCDS1853.1
    UniProtKB/Swiss-Prot
    P46199
    Conserved Domains (5) summary
    cd01887
    Location:181345
    IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
    COG0532
    Location:176718
    InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
    pfam11987
    Location:515606
    IF-2; Translation-initiation factor 2
    cd03692
    Location:624711
    mtIF2_IVc; C2 subdomain of domain IV in mitochondrial translation initiation factor 2
    cd03702
    Location:354448
    IF2_mtIF2_II; Domain II of bacterial and mitochondrial Initiation Factor 2
  5. NM_001321004.1NP_001307933.1  translation initiation factor IF-2, mitochondrial isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AC012358, AF494407, BU681583, CB961193, DB478758
    Consensus CDS
    CCDS1853.1
    UniProtKB/Swiss-Prot
    P46199
    Conserved Domains (5) summary
    cd01887
    Location:181345
    IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
    COG0532
    Location:176718
    InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
    pfam11987
    Location:515606
    IF-2; Translation-initiation factor 2
    cd03692
    Location:624711
    mtIF2_IVc; C2 subdomain of domain IV in mitochondrial translation initiation factor 2
    cd03702
    Location:354448
    IF2_mtIF2_II; Domain II of bacterial and mitochondrial Initiation Factor 2
  6. NM_001321005.1NP_001307934.1  translation initiation factor IF-2, mitochondrial isoform b

    Status: REVIEWED

    Source sequence(s)
    AC012358, AF494407, BU681583, CB961193
    UniProtKB/Swiss-Prot
    P46199
    Conserved Domains (4) summary
    pfam11987
    Location:272363
    IF-2; Translation-initiation factor 2
    cd03692
    Location:381468
    mtIF2_IVc; C2 subdomain of domain IV in mitochondrial translation initiation factor 2
    cd03702
    Location:111205
    IF2_mtIF2_II; Domain II of bacterial and mitochondrial Initiation Factor 2
    cl21455
    Location:1102
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  7. NM_002453.3NP_002444.2  translation initiation factor IF-2, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_002444.2

    Status: REVIEWED

    Source sequence(s)
    AC012358, AF494407, BC064977, BU684812, CB961193
    Consensus CDS
    CCDS1853.1
    UniProtKB/Swiss-Prot
    P46199
    UniProtKB/TrEMBL
    Q6P1N2
    Related
    ENSP00000263629.4, ENST00000263629.9
    Conserved Domains (5) summary
    cd01887
    Location:181345
    IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
    COG0532
    Location:176718
    InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
    pfam11987
    Location:515606
    IF-2; Translation-initiation factor 2
    cd03692
    Location:624711
    mtIF2_IVc; C2 subdomain of domain IV in mitochondrial translation initiation factor 2
    cd03702
    Location:354448
    IF2_mtIF2_II; Domain II of bacterial and mitochondrial Initiation Factor 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    55235583..55269314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004164.2XP_016859653.1  translation initiation factor IF-2, mitochondrial isoform X2

  2. XM_017004162.2XP_016859651.1  translation initiation factor IF-2, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    P46199
    Conserved Domains (5) summary
    cd01887
    Location:181345
    IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
    COG0532
    Location:176718
    InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
    pfam11987
    Location:515606
    IF-2; Translation-initiation factor 2
    cd03692
    Location:624711
    mtIF2_IVc; C2 subdomain of domain IV in mitochondrial translation initiation factor 2
    cd03702
    Location:354448
    IF2_mtIF2_II; Domain II of bacterial and mitochondrial Initiation Factor 2
  3. XM_017004165.1XP_016859654.1  translation initiation factor IF-2, mitochondrial isoform X3

    Conserved Domains (4) summary
    pfam11987
    Location:272363
    IF-2; Translation-initiation factor 2
    cd03692
    Location:381468
    mtIF2_IVc; C2 subdomain of domain IV in mitochondrial translation initiation factor 2
    cd03702
    Location:111205
    IF2_mtIF2_II; Domain II of bacterial and mitochondrial Initiation Factor 2
    cl21455
    Location:1102
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_017004166.1XP_016859655.1  translation initiation factor IF-2, mitochondrial isoform X3

    Conserved Domains (4) summary
    pfam11987
    Location:272363
    IF-2; Translation-initiation factor 2
    cd03692
    Location:381468
    mtIF2_IVc; C2 subdomain of domain IV in mitochondrial translation initiation factor 2
    cd03702
    Location:111205
    IF2_mtIF2_II; Domain II of bacterial and mitochondrial Initiation Factor 2
    cl21455
    Location:1102
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. XM_011532871.2XP_011531173.1  translation initiation factor IF-2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011531173.1

    UniProtKB/Swiss-Prot
    P46199
    Related
    ENSP00000384481.1, ENST00000403721.5
    Conserved Domains (5) summary
    cd01887
    Location:181345
    IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
    COG0532
    Location:176718
    InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
    pfam11987
    Location:515606
    IF-2; Translation-initiation factor 2
    cd03692
    Location:624711
    mtIF2_IVc; C2 subdomain of domain IV in mitochondrial translation initiation factor 2
    cd03702
    Location:354448
    IF2_mtIF2_II; Domain II of bacterial and mitochondrial Initiation Factor 2
  6. XM_017004163.1XP_016859652.1  translation initiation factor IF-2, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    P46199
    Conserved Domains (5) summary
    cd01887
    Location:181345
    IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
    COG0532
    Location:176718
    InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
    pfam11987
    Location:515606
    IF-2; Translation-initiation factor 2
    cd03692
    Location:624711
    mtIF2_IVc; C2 subdomain of domain IV in mitochondrial translation initiation factor 2
    cd03702
    Location:354448
    IF2_mtIF2_II; Domain II of bacterial and mitochondrial Initiation Factor 2
  7. XM_005264335.3XP_005264392.1  translation initiation factor IF-2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005264392.1

    UniProtKB/Swiss-Prot
    P46199
    Conserved Domains (5) summary
    cd01887
    Location:181345
    IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
    COG0532
    Location:176718
    InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
    pfam11987
    Location:515606
    IF-2; Translation-initiation factor 2
    cd03692
    Location:624711
    mtIF2_IVc; C2 subdomain of domain IV in mitochondrial translation initiation factor 2
    cd03702
    Location:354448
    IF2_mtIF2_II; Domain II of bacterial and mitochondrial Initiation Factor 2
  8. XM_017004167.2XP_016859656.1  translation initiation factor IF-2, mitochondrial isoform X4

    Conserved Domains (3) summary
    pfam11987
    Location:184275
    IF-2; Translation-initiation factor 2
    cd03692
    Location:293380
    mtIF2_IVc; C2 subdomain of domain IV in mitochondrial translation initiation factor 2
    cd03702
    Location:23117
    IF2_mtIF2_II; Domain II of bacterial and mitochondrial Initiation Factor 2
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