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Mtif2 mitochondrial translational initiation factor 2 [ Mus musculus (house mouse) ]

Gene ID: 76784, updated on 18-Sep-2024

Summary

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Official Symbol
Mtif2provided by MGI
Official Full Name
mitochondrial translational initiation factor 2provided by MGI
Primary source
MGI:MGI:1924034
See related
Ensembl:ENSMUSG00000020459 AllianceGenome:MGI:1924034
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IF-2mt; IF2(mt); IF-2(Mt); 2310038D14Rik; 2410112O06Rik
Summary
Predicted to enable GTP binding activity; GTPase activity; and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in liver lobe; testis; and vibrissa. Orthologous to human MTIF2 (mitochondrial translational initiation factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.0), CNS E14 (RPKM 7.9) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Mtif2 in Genome Data Viewer
Location:
11 A3.3; 11 16.77 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (29475352..29495452)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (29525352..29545452)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene coiled coil domain containing 88A Neighboring gene predicted gene, 51886 Neighboring gene STARR-seq mESC enhancer starr_29023 Neighboring gene STARR-positive B cell enhancer ABC_E3936 Neighboring gene prolyl-tRNA synthetase domain containing 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:29426294-29426403 Neighboring gene STARR-seq mESC enhancer starr_29024 Neighboring gene ribosomal protein S27A Neighboring gene 60S ribosomal protein L7-like Neighboring gene clathrin heavy chain linker domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of mammalian mitochondrial translational initiation factor 3 and examination of its role in initiation complex formation with natural mRNAs. Koc EC, et al. J Biol Chem, 2002 Sep 20. PMID 12095986
  2. Phosphoproteome analysis of mouse liver using immobilized metal affinity purification and linear ion trap mass spectrometry. Jin WH, et al. Rapid Commun Mass Spectrom, 2004. PMID 15378723
  3. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
  4. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  5. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 2310038D14Rik, 2410112O06Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribosomal small subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables translation factor activity, RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ribosome disassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
translation initiation factor IF-2, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282118.1 → NP_001269047.1  translation initiation factor IF-2, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_001269047.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK136344, BX284634, CF737093
    Consensus CDS
    CCDS24496.1
    UniProtKB/Swiss-Prot
    Q5M6W6, Q91YJ5
    Related
    ENSMUSP00000020749.7, ENSMUST00000020749.13
    Conserved Domains (1) summary
    cl30717
    Location:72 → 720
    InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

  2. NM_001282119.1 → NP_001269048.1  translation initiation factor IF-2, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a longer and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK136344, BX284634, CF737093, CK620846
    UniProtKB/Swiss-Prot
    Q91YJ5
    Conserved Domains (5) summary
    cd01887
    Location:200 → 364
    IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
    COG0532
    Location:195 → 737
    InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
    pfam11987
    Location:534 → 625
    IF-2; Translation-initiation factor 2
    cd03692
    Location:643 → 730
    mtIF2_IVc; C2 subdomain of domain IV in mitochondrial translation initiation factor 2
    cd03702
    Location:373 → 467
    IF2_mtIF2_II; Domain II of bacterial and mitochondrial Initiation Factor 2

  3. NM_001282120.1 → NP_001269049.1  translation initiation factor IF-2, mitochondrial isoform 3

    See identical proteins and their annotated locations for NP_001269049.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK146961, BX284634, CF737093, CK620846
    UniProtKB/Swiss-Prot
    Q91YJ5
    Conserved Domains (1) summary
    cl30717
    Location:25 → 574
    InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

  4. NM_133767.3 → NP_598528.2  translation initiation factor IF-2, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_598528.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (1). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK146961, BX284634, CF737093, CK620846
    Consensus CDS
    CCDS24496.1
    UniProtKB/Swiss-Prot
    Q5M6W6, Q91YJ5
    Related
    ENSMUSP00000090926.5, ENSMUST00000093239.11
    Conserved Domains (1) summary
    cl30717
    Location:72 → 720
    InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    29475352..29495452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514892.4 → XP_006514955.1  translation initiation factor IF-2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006514955.1

    UniProtKB/Swiss-Prot
    Q5M6W6, Q91YJ5
    Conserved Domains (1) summary
    cl30717
    Location:72 → 720
    InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

  2. XM_036157080.1 → XP_036012973.1  translation initiation factor IF-2, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl30717
    Location:25 → 574
    InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

  3. XM_030246423.1 → XP_030102283.1  translation initiation factor IF-2, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl30717
    Location:1 → 624
    InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

  4. XM_030246424.1 → XP_030102284.1  translation initiation factor IF-2, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl30717
    Location:25 → 574
    InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

  5. XM_036157081.1 → XP_036012974.1  translation initiation factor IF-2, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl30717
    Location:25 → 574
    InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

  6. XM_006514891.3 → XP_006514954.1  translation initiation factor IF-2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006514954.1

    UniProtKB/Swiss-Prot
    Q5M6W6, Q91YJ5
    Conserved Domains (1) summary
    cl30717
    Location:72 → 720
    InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

RNA

  1. XR_003949529.1 RNA Sequence

  2. XR_380987.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YJ5.2 GenPept UniProtKB/Swiss-Prot:Q91YJ5

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