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MTF1 metal regulatory transcription factor 1 [ Homo sapiens (human) ]

Gene ID: 4520, updated on 24-Nov-2020

Summary

Official Symbol
MTF1provided by HGNC
Official Full Name
metal regulatory transcription factor 1provided by HGNC
Primary source
HGNC:HGNC:7428
See related
Ensembl:ENSG00000188786 MIM:600172
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZRF; MTF-1
Summary
This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 7.9), testis (RPKM 4.9) and 25 other tissues See more
Orthologs
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Genomic context

See MTF1 in Genome Data Viewer
Location:
1p34.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (37809570..37859614, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (38275239..38325292, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mannosidase endo-alpha like Neighboring gene chromosome 1 open reading frame 122 Neighboring gene yrdC N6-threonylcarbamoyltransferase domain containing Neighboring gene ribosomal protein S2 pseudogene 13 Neighboring gene inositol polyphosphate-5-phosphatase B Neighboring gene RNA, U6 small nuclear 584, pseudogene Neighboring gene uncharacterized LOC105378651

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
GeneReviews: Not available
Novel associations for hypothyroidism include known autoimmune risk loci.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC23036

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cartilage homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular response to zinc ion IEA
Inferred from Electronic Annotation
more info
 
central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to cadmium ion IEA
Inferred from Electronic Annotation
more info
 
response to metal ion TAS
Traceable Author Statement
more info
 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
metal regulatory transcription factor 1
Names
MRE-binding transcription factor
MRE-binding transcription factor-1
metal-responsive transcription factor 1
transcription factor MTF-1
zinc regulatory factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005955.3NP_005946.2  metal regulatory transcription factor 1

    See identical proteins and their annotated locations for NP_005946.2

    Status: REVIEWED

    Source sequence(s)
    AI915521, AL929472, BC014454, X78710
    Consensus CDS
    CCDS30676.1
    UniProtKB/Swiss-Prot
    Q14872
    Related
    ENSP00000362127.3, ENST00000373036.5
    Conserved Domains (4) summary
    COG5048
    Location:93291
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:234253
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:245271
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:231319
    zf-C2H2_8; C2H2-type zinc ribbon

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    37809570..37859614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541494.1XP_011539796.1  metal regulatory transcription factor 1 isoform X3

  2. XM_011541491.2XP_011539793.1  metal regulatory transcription factor 1 isoform X1

    See identical proteins and their annotated locations for XP_011539793.1

    UniProtKB/Swiss-Prot
    Q14872
    Conserved Domains (4) summary
    COG5048
    Location:93291
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:234253
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:245271
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:231319
    zf-C2H2_8; C2H2-type zinc ribbon
  3. XM_011541493.3XP_011539795.1  metal regulatory transcription factor 1 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:93291
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:234253
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:245271
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:231319
    zf-C2H2_8; C2H2-type zinc ribbon
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