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MST1R macrophage stimulating 1 receptor [ Homo sapiens (human) ]

Gene ID: 4486, updated on 11-Sep-2019

Summary

Official Symbol
MST1Rprovided by HGNC
Official Full Name
macrophage stimulating 1 receptorprovided by HGNC
Primary source
HGNC:HGNC:7381
See related
Ensembl:ENSG00000164078 MIM:600168
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RON; SEA; PTK8; CD136; NPCA3; CDw136
Summary
This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]
Expression
Biased expression in skin (RPKM 17.5), stomach (RPKM 16.3) and 9 other tissues See more
Orthologs

Genomic context

See MST1R in Genome Data Viewer
Location:
3p21.31
Exon count:
21
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (49886471..49903873, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (49924435..49941311, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 217, pseudogene Neighboring gene CaM kinase like vesicle associated Neighboring gene ACTB pseudogene 13 Neighboring gene uncharacterized LOC102724438 Neighboring gene MON1 homolog A, secretory trafficking associated Neighboring gene RNA binding motif protein 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Nasopharyngeal carcinoma, susceptibility to, 3
MedGen: C4310729 OMIM: 617075 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Tat trans activation domain and the integrity of the kinase domain of RON receptor are required for Tat-mediated degradation of RON PubMed
tat Tat decreases cell surface RON expression in HIV-infected monocytic cells, and this Tat-mediated degradation of RON protein is blocked by inhibitors of proteasome activity PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
macrophage colony-stimulating factor receptor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response TAS
Traceable Author Statement
more info
PubMed 
hepatocyte growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
macrophage colony-stimulating factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of protein kinase B signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
response to virus IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
single fertilization TAS
Traceable Author Statement
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell surface HDA PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress fiber IEA
Inferred from Electronic Annotation
more info
 
vacuole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
macrophage-stimulating protein receptor
Names
MSP receptor
PTK8 protein tyrosine kinase 8
S13 avian erythroblastosis oncogene homolog
S13 erythroblastosis oncogene homolog
c-met-related tyrosine kinase
p185-Ron
NP_001231866.1
NP_001305842.1
NP_002438.2
XP_005265227.2
XP_011532041.1
XP_011532042.1
XP_011532043.1
XP_011532044.1
XP_011532045.1
XP_011532046.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030322.1 RefSeqGene

    Range
    5001..21872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001244937.3NP_001231866.1  macrophage-stimulating protein receptor isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2, also known as isoform delta-Ron) missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC105935, AK303234, BU542597, CA503122, EU826584, X70040
    Consensus CDS
    CCDS58833.1
    UniProtKB/Swiss-Prot
    Q04912
    UniProtKB/TrEMBL
    B4E058
    Related
    ENSP00000341325.4, ENST00000344206.8
    Conserved Domains (7) summary
    smart00219
    Location:10361289
    TyrKc; Tyrosine kinase, catalytic domain
    cd11279
    Location:27523
    Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
    smart00429
    Location:769859
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:684768
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:569683
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:10371298
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    pfam01437
    Location:526565
    PSI; Plexin repeat
  2. NM_001318913.1NP_001305842.1  macrophage-stimulating protein receptor isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. It encodes isoform 3 which is shorter than isoform 1. This isoform (3) may undergo proteolytic processing similar to isoform 1.
    Source sequence(s)
    AC105935, CA503122, JN983806
    Consensus CDS
    CCDS82777.1
    UniProtKB/TrEMBL
    A0A087WZG2, G9JXB8
    Related
    ENSP00000482642.1, ENST00000621387.4
    Conserved Domains (7) summary
    smart00219
    Location:9791232
    TyrKc; Tyrosine kinase, catalytic domain
    smart00429
    Location:663753
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:578662
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:463577
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:9801241
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    pfam01437
    Location:420459
    PSI; Plexin repeat
    cl15693
    Location:27426
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
  3. NM_002447.4NP_002438.2  macrophage-stimulating protein receptor isoform 1 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as isoform Ron).
    Source sequence(s)
    AC105935, CA503122, X70040
    Consensus CDS
    CCDS2807.1
    UniProtKB/Swiss-Prot
    Q04912
    Related
    ENSP00000296474.3, ENST00000296474.8
    Conserved Domains (6) summary
    cd11279
    Location:27523
    Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
    smart00429
    Location:769859
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:684768
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:569683
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:10861347
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    pfam01437
    Location:526565
    PSI; Plexin repeat

RNA

  1. NR_134919.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC105935, CA503122, HQ908652, JN983806
    Related
    ENST00000411578.6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    49886471..49903873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533743.2XP_011532045.1  macrophage-stimulating protein receptor isoform X6

    Conserved Domains (6) summary
    cd11279
    Location:27523
    Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
    smart00429
    Location:769860
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:684768
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:569683
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:526565
    PSI; Plexin repeat
    cl21453
    Location:10871247
    PKc_like; Protein Kinases, catalytic domain
  2. XM_011533744.2XP_011532046.1  macrophage-stimulating protein receptor isoform X7

    Conserved Domains (7) summary
    smart00219
    Location:9801233
    TyrKc; Tyrosine kinase, catalytic domain
    smart00429
    Location:663754
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:578662
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:463577
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:9811242
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    pfam01437
    Location:420459
    PSI; Plexin repeat
    cl15693
    Location:27426
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
  3. XM_011533740.2XP_011532042.1  macrophage-stimulating protein receptor isoform X3

    Conserved Domains (7) summary
    smart00219
    Location:10371290
    TyrKc; Tyrosine kinase, catalytic domain
    cd11279
    Location:27523
    Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
    smart00429
    Location:769860
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:684768
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:569683
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:10381299
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    pfam01437
    Location:526565
    PSI; Plexin repeat
  4. XM_011533739.2XP_011532041.1  macrophage-stimulating protein receptor isoform X2

    Conserved Domains (7) summary
    smart00219
    Location:10461299
    TyrKc; Tyrosine kinase, catalytic domain
    cd11279
    Location:27523
    Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
    smart00429
    Location:769860
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:684768
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:569683
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:10471308
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    pfam01437
    Location:526565
    PSI; Plexin repeat
  5. XM_011533741.2XP_011532043.1  macrophage-stimulating protein receptor isoform X4

    Conserved Domains (7) summary
    smart00219
    Location:10211270
    TyrKc; Tyrosine kinase, catalytic domain
    cd11279
    Location:27523
    Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
    smart00429
    Location:769860
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:684768
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:569683
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:10211279
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    pfam01437
    Location:526565
    PSI; Plexin repeat
  6. XM_005265170.4XP_005265227.2  macrophage-stimulating protein receptor isoform X1

    Conserved Domains (7) summary
    smart00219
    Location:10861339
    TyrKc; Tyrosine kinase, catalytic domain
    cd11279
    Location:27523
    Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
    smart00429
    Location:769860
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:684768
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:569683
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:10871348
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    pfam01437
    Location:526565
    PSI; Plexin repeat
  7. XM_011533742.2XP_011532044.1  macrophage-stimulating protein receptor isoform X5

    Conserved Domains (6) summary
    cd11279
    Location:27523
    Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
    smart00429
    Location:769860
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:684768
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:569683
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:526565
    PSI; Plexin repeat
    cl21453
    Location:10871271
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001740155.1 RNA Sequence

  2. XR_940428.2 RNA Sequence

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