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Mst1r macrophage stimulating 1 receptor (c-met-related tyrosine kinase) [ Mus musculus (house mouse) ]

Gene ID: 19882, updated on 6-Jun-2024

Summary

Official Symbol
Mst1rprovided by MGI
Official Full Name
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)provided by MGI
Primary source
MGI:MGI:99614
See related
Ensembl:ENSMUSG00000032584 AllianceGenome:MGI:99614
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fv2; Ron; STK; Fv-2; PTK8; CD136; CDw136; p185-Ron
Summary
This gene encodes a precursor protein that is proteolytically cleaved to yield an alpha chain and a beta chain which form a membrane-spanning heterodimer. The encoded protein belongs to a family of cell-surface receptor tyrosine kinases involved in signaling from the cell surface to the intracellular environment. The binding of the encoded protein to its ligand, macrophage-stimulating protein, mediates several biological activities including wound healing, tumor immunity, macrophage activation and hematopoiesis as well as cell growth, motility, survival and adhesion. The protein encoded by this gene also functions in early development and the macrophage-mediated inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Expression
Biased expression in stomach adult (RPKM 26.6), colon adult (RPKM 26.4) and 12 other tissues See more
Orthologs
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Genomic context

See Mst1r in Genome Data Viewer
Location:
9 59.07 cM; 9 F1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107784057..107797582)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107906858..107920383)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene MON1 homolog A, secretory traffciking associated Neighboring gene predicted gene, 23856 Neighboring gene actin-like 11 Neighboring gene CaM kinase-like vesicle-associated

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in stress fiber IDA
Inferred from Direct Assay
more info
PubMed 
located_in vacuole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
macrophage-stimulating protein receptor
Names
MSP receptor
friend virus susceptibility 2
receptor protein tyrosine kinase, c-met-related
stem cell-derived tyrosine kinase
NP_001274190.1
NP_001400491.1
NP_033100.2
XP_006511717.1
XP_006511718.1
XP_006511721.1
XP_017168707.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287261.2NP_001274190.1  macrophage-stimulating protein receptor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL731808
    Conserved Domains (1) summary
    cl21453
    Location:162423
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001413562.1NP_001400491.1  macrophage-stimulating protein receptor isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL731808
    UniProtKB/TrEMBL
    B2RUR6
  3. NM_009074.3NP_033100.2  macrophage-stimulating protein receptor isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_033100.2

    Status: VALIDATED

    Source sequence(s)
    AL731808
    Consensus CDS
    CCDS23509.1
    UniProtKB/Swiss-Prot
    E9QMZ4, Q62190, Q62555
    UniProtKB/TrEMBL
    B2RUR6
    Related
    ENSMUSP00000035203.8, ENSMUST00000035203.9
    Conserved Domains (7) summary
    cd11279
    Location:29525
    Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
    smart00429
    Location:771863
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:686770
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:10631324
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    pfam01437
    Location:528567
    PSI; Plexin repeat
    pfam07714
    Location:10591315
    Pkinase_Tyr; Protein tyrosine kinase
    cl15674
    Location:571685
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

RNA

  1. NR_109782.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL731808
    Related
    ENSMUST00000195617.6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107784057..107797582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511654.4XP_006511717.1  macrophage-stimulating protein receptor isoform X1

    UniProtKB/TrEMBL
    B2RUR6
    Conserved Domains (6) summary
    cd11279
    Location:29525
    Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
    smart00423
    Location:528570
    PSI; domain found in Plexins, Semaphorins and Integrins
    smart00429
    Location:771864
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:686770
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cl15674
    Location:571685
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    cl21453
    Location:10641352
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006511655.4XP_006511718.1  macrophage-stimulating protein receptor isoform X2

    UniProtKB/TrEMBL
    B2RUR6
    Conserved Domains (6) summary
    cd11279
    Location:29525
    Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
    smart00423
    Location:528570
    PSI; domain found in Plexins, Semaphorins and Integrins
    smart00429
    Location:771863
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:686770
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cl15674
    Location:571685
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    cl21453
    Location:10631351
    PKc_like; Protein Kinases, catalytic domain
  3. XM_006511658.3XP_006511721.1  macrophage-stimulating protein receptor isoform X5

    Conserved Domains (3) summary
    cd11279
    Location:29525
    Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
    smart00423
    Location:528570
    PSI; domain found in Plexins, Semaphorins and Integrins
    cl15674
    Location:571685
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  4. XM_017313218.1XP_017168707.1  macrophage-stimulating protein receptor isoform X4

    Conserved Domains (6) summary
    smart00423
    Location:99141
    PSI; domain found in Plexins, Semaphorins and Integrins
    smart00429
    Location:342435
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:257341
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cl15674
    Location:142256
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    cl15693
    Location:196
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
    cl21453
    Location:635923
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_379757.5 RNA Sequence

  2. XR_379756.5 RNA Sequence