ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) [Homo sapiens (human)] - Gene

Summary

Official Symbol: ABCC1provided by HGNC
Official Full Name: ATP binding cassette subfamily C member 1 (ABCC1 blood group)provided by HGNC
Primary source: HGNC:HGNC:51
See related: Ensembl:ENSG00000103222 MIM:158343; AllianceGenome:HGNC:51
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MRP; ABCC; GS-X; MRP1; ABC29; DFNA77
Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]
Expression: Ubiquitous expression in testis (RPKM 13.5), esophagus (RPKM 9.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p13.11

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (15949143..16143053)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (15954068..16147908)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (16043473..16236910)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of multidrug resistance-associated protein 1 protects against cardiotoxicity by augmenting the doxorubicin efflux from cardiomyocytes.
Title: Overexpression of multidrug resistance-associated protein 1 protects against cardiotoxicity by augmenting the doxorubicin efflux from cardiomyocytes.
Restoring microRNA-34a overcomes acquired drug resistance and disease progression in human breast cancer cell lines via suppressing the ABCC1 gene.
Title: Restoring microRNA-34a overcomes acquired drug resistance and disease progression in human breast cancer cell lines via suppressing the ABCC1 gene.
The role and impact of alternative polyadenylation and miRNA regulation on the expression of the multidrug resistance-associated protein 1 (MRP-1/ABCC1) in epithelial ovarian cancer.
Title: The role and impact of alternative polyadenylation and miRNA regulation on the expression of the multidrug resistance-associated protein 1 (MRP-1/ABCC1) in epithelial ovarian cancer.
Tumor-associated macrophages confer colorectal cancer 5-fluorouracil resistance by promoting MRP1 membrane translocation via an intercellular CXCL17/CXCL22-CCR4-ATF6-GRP78 axis.
Title: Tumor-associated macrophages confer colorectal cancer 5-fluorouracil resistance by promoting MRP1 membrane translocation via an intercellular CXCL17/CXCL22-CCR4-ATF6-GRP78 axis.
Genetic Polymorphisms in SLCO2B1 and ABCC1 Conjointly Modulate Atorvastatin Intracellular Accumulation in HEK293 Recombinant Cell Lines.
Title: Genetic Polymorphisms in SLCO2B1 and ABCC1 Conjointly Modulate Atorvastatin Intracellular Accumulation in HEK293 Recombinant Cell Lines.
Genetic variations in ABC transporter genes as a predictive biomarker for toxicity in North Indian lung cancer patients undergoing platinum-based doublet chemotherapy.
Title: Genetic variations in ABC transporter genes as a predictive biomarker for toxicity in North Indian lung cancer patients undergoing platinum-based doublet chemotherapy.
CircSETDB1 contributes to paclitaxel resistance of ovarian cancer cells by sponging miR-508-3p and regulating ABCC1 expression.
Title: CircSETDB1 contributes to paclitaxel resistance of ovarian cancer cells by sponging miR-508-3p and regulating ABCC1 expression.
The ATP-binding cassette proteins ABCB1 and ABCC1 as modulators of glucocorticoid action.
Title: The ATP-binding cassette proteins ABCB1 and ABCC1 as modulators of glucocorticoid action.
Knockout of ABCC1 in NCI-H441 cells reveals CF to be a suboptimal substrate to study MRP1 activity in organotypic in vitro models.
Title: Knockout of ABCC1 in NCI-H441 cells reveals CF to be a suboptimal substrate to study MRP1 activity in organotypic in vitro models.
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP.
Title: ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP.

Submit: New GeneRIF Correction See all GeneRIFs (330)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Hearing loss, autosomal dominant 77 MedGen: C5394499 OMIM: 618915 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	NF-kappaB and JNK signaling are involved in gp120-induced multidrug resistance protein 1 (Mrp1) regulation during an HIV-1 associated inflammatory response	PubMed
Tat	tat	HIV-1 Tat upregulates expression of MRP1 through activation of the mitogen-activated protein kinase signaling cascade	PubMed
	tat	HIV-1 Tat specifically upregulates MRP1 messenger ribonucleic acid and protein expression both in brain micro vascular endothelial cells (BMEC) and astrocytes	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH64912 (e-PCR)
- UniSTS:89088

D16S2586E (e-PCR)
- UniSTS:41525

RH79017 (e-PCR)
- UniSTS:42874

SHGC-12494 (e-PCR)
- UniSTS:31614

RH65306 (e-PCR)
- UniSTS:86403

G63601 (e-PCR)
- UniSTS:140712

SHGC-147442 (e-PCR)
- UniSTS:175812

ABCC1_679 (e-PCR)
- UniSTS:276950

ABCC1_V58 (e-PCR)
- UniSTS:276950

SHGC-60500 (e-PCR)
- UniSTS:9688

SHGC-5825 (e-PCR)
- UniSTS:32497

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ABC-type glutathione S-conjugate transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type glutathione S-conjugate transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ABC-type transporter activity	EXP Inferred from Experiment more info	PubMed
enables ABC-type transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type transporter activity	TAS Traceable Author Statement more info
enables ABC-type vitamin B12 transporter activity	EXP Inferred from Experiment more info	PubMed
enables ABC-type vitamin B12 transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type xenobiotic transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ABC-type xenobiotic transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled inorganic anion transmembrane transporter activity	TAS Traceable Author Statement more info
enables ATPase-coupled lipid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATPase-coupled transmembrane transporter activity	TAS Traceable Author Statement more info
enables carboxylic acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables efflux transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables efflux transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables efflux transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables glutathione transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables glutathione transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables sphingolipid transporter activity	TAS Traceable Author Statement more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables xenobiotic transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables xenobiotic transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables xenobiotic transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables xenobiotic transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in carboxylic acid transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cellular response to amyloid-beta	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amyloid-beta	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cellular response to oxidative stress	TAS Traceable Author Statement more info
involved_in cobalamin transport	IEA Inferred from Electronic Annotation more info
involved_in cobalamin transport	TAS Traceable Author Statement more info
involved_in cyclic nucleotide transport	IEA Inferred from Electronic Annotation more info
involved_in cyclic nucleotide transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in export across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in export across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in export across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in glutathione transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme catabolic process	TAS Traceable Author Statement more info
involved_in leukotriene metabolic process	TAS Traceable Author Statement more info
involved_in leukotriene transport	IEA Inferred from Electronic Annotation more info
involved_in leukotriene transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in phospholipid translocation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to xenobiotic stimulus	TAS Traceable Author Statement more info	PubMed
involved_in sphingolipid biosynthetic process	TAS Traceable Author Statement more info
involved_in sphingolipid translocation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transepithelial transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	TAS Traceable Author Statement more info
involved_in transport across blood-brain barrier	NAS Non-traceable Author Statement more info	PubMed
involved_in xenobiotic metabolic process	TAS Traceable Author Statement more info
involved_in xenobiotic transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in xenobiotic transport across blood-brain barrier	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in basal plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: multidrug resistance-associated protein 1

Names: ATP-binding cassette transporter variant ABCC1delta-ex13; ATP-binding cassette transporter variant ABCC1delta-ex13&14; ATP-binding cassette transporter variant ABCC1delta-ex25; ATP-binding cassette transporter variant ABCC1delta-ex25&26; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; LTC4 transporter; glutathione S-conjugate export pump; glutathione-S-conjugate-translocating ATPase ABCC1; leukotriene C(4) transporter

NP_004987.2

EC 7.6.2.2

EC 7.6.2.3

NP_063915.2

EC 7.6.2.2

EC 7.6.2.3

XP_011520799.1

EC 7.6.2.2

EC 7.6.2.3

XP_016878726.1

EC 7.6.2.2

EC 7.6.2.3

XP_047290087.1

EC 7.6.2.2

EC 7.6.2.3

XP_047290088.1

EC 7.6.2.2

EC 7.6.2.3

XP_047290089.1

EC 7.6.2.2

EC 7.6.2.3

XP_047290090.1

EC 7.6.2.2

EC 7.6.2.3

XP_047290091.1

EC 7.6.2.2

EC 7.6.2.3

XP_047290092.1

EC 7.6.2.2

EC 7.6.2.3

XP_047290093.1

EC 7.6.2.2

EC 7.6.2.3

XP_047290094.1

EC 7.6.2.2

EC 7.6.2.3

XP_047290096.1

EC 7.6.2.2

EC 7.6.2.3

XP_047290097.1

EC 7.6.2.2

EC 7.6.2.3

XP_047290098.1

EC 7.6.2.2

EC 7.6.2.3

XP_047290100.1

EC 7.6.2.2

EC 7.6.2.3

XP_047290101.1

EC 7.6.2.2

EC 7.6.2.3

XP_047290102.1

EC 7.6.2.2

EC 7.6.2.3

XP_047290103.1

EC 7.6.2.2

EC 7.6.2.3

XP_047290104.1

EC 7.6.2.2

EC 7.6.2.3

XP_047290105.1

EC 7.6.2.2

EC 7.6.2.3

XP_047290107.1

EC 7.6.2.2

EC 7.6.2.3

XP_047290108.1

EC 7.6.2.2

EC 7.6.2.3

XP_047290109.1

EC 7.6.2.2

EC 7.6.2.3

XP_047290110.1

EC 7.6.2.2

EC 7.6.2.3

XP_054185047.1

EC 7.6.2.2

EC 7.6.2.3

XP_054185048.1

EC 7.6.2.2

EC 7.6.2.3

XP_054185049.1

EC 7.6.2.2

EC 7.6.2.3

XP_054185050.1

EC 7.6.2.2

EC 7.6.2.3

XP_054185051.1

EC 7.6.2.2

EC 7.6.2.3

XP_054185052.1

EC 7.6.2.2

EC 7.6.2.3

XP_054185053.1

EC 7.6.2.2

EC 7.6.2.3

XP_054185054.1

EC 7.6.2.2

EC 7.6.2.3

XP_054185055.1

EC 7.6.2.2

EC 7.6.2.3

XP_054185056.1

EC 7.6.2.2

EC 7.6.2.3

XP_054185057.1

EC 7.6.2.2

EC 7.6.2.3

XP_054185058.1

EC 7.6.2.2

EC 7.6.2.3

XP_054185059.1

EC 7.6.2.2

EC 7.6.2.3

XP_054185060.1

EC 7.6.2.2

EC 7.6.2.3

XP_054185061.1

EC 7.6.2.2

EC 7.6.2.3

XP_054185062.1

EC 7.6.2.2

EC 7.6.2.3

XP_054185063.1

EC 7.6.2.2

EC 7.6.2.3

XP_054185064.1

EC 7.6.2.2

EC 7.6.2.3

XP_054185065.1

EC 7.6.2.2

EC 7.6.2.3

XP_054185066.1

EC 7.6.2.2

EC 7.6.2.3

XP_054185067.1

EC 7.6.2.2

EC 7.6.2.3

XP_054185068.1

EC 7.6.2.2

EC 7.6.2.3

XP_054185069.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236323.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236324.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236325.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236326.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236327.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236328.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236329.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236330.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236331.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236332.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236333.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236334.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236335.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236336.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236337.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236338.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236339.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236340.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236341.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236342.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236343.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236344.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236345.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236346.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236347.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236348.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236349.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236350.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236351.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236352.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236353.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236354.1

EC 7.6.2.2

EC 7.6.2.3

XP_054236355.1

EC 7.6.2.2

EC 7.6.2.3

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_028268.2 RefSeqGene

Range

5040..198477

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_004996.4 → NP_004987.2 multidrug resistance-associated protein 1 isoform 1

See identical proteins and their annotated locations for NP_004987.2

Status: REVIEWED

Source sequence(s)

AC025778, AC136624, X78338

Consensus CDS

CCDS42122.1

UniProtKB/Swiss-Prot

A3RJX2, C9JPJ4, O14819, O43333, P33527, P78419, Q59GI9, Q9UQ97, Q9UQ99, Q9UQA0

UniProtKB/TrEMBL

I3L4X2

Related

ENSP00000382342.3, ENST00000399410.8

Conserved Domains (1) summary

TIGR00957
Location:7 → 1530

MRP_assoc_pro; multi drug resistance-associated protein (MRP)
NM_019862.3 → NP_063915.2 multidrug resistance-associated protein 1 isoform 2

Status: REVIEWED

Source sequence(s)

AC025778, AC130651, AC136624, KC877577

Consensus CDS

CCDS45427.1

UniProtKB/TrEMBL

Q9UQ98

Related

ENSP00000461615.2, ENST00000572882.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

15949143..16143053

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047434134.1 → XP_047290090.1 multidrug resistance-associated protein 1 isoform X5

UniProtKB/TrEMBL

I3L4X2
XM_047434149.1 → XP_047290105.1 multidrug resistance-associated protein 1 isoform X19

UniProtKB/TrEMBL

Q9UQ98
XM_047434141.1 → XP_047290097.1 multidrug resistance-associated protein 1 isoform X12

UniProtKB/TrEMBL

I3L4X2
XM_047434148.1 → XP_047290104.1 multidrug resistance-associated protein 1 isoform X18

UniProtKB/TrEMBL

Q9UQ98
XM_047434154.1 → XP_047290110.1 multidrug resistance-associated protein 1 isoform X23

UniProtKB/TrEMBL

Q9UQ98
XM_047434138.1 → XP_047290094.1 multidrug resistance-associated protein 1 isoform X10

UniProtKB/TrEMBL

I3L4X2
XM_047434147.1 → XP_047290103.1 multidrug resistance-associated protein 1 isoform X17

UniProtKB/TrEMBL

Q9UQ98
XM_047434153.1 → XP_047290109.1 multidrug resistance-associated protein 1 isoform X22

UniProtKB/TrEMBL

A0A7I2V2E0, Q9UQ98

Related

ENSP00000502873.1, ENST00000677164.1
XM_047434146.1 → XP_047290102.1 multidrug resistance-associated protein 1 isoform X16

UniProtKB/TrEMBL

I3L4X2
XM_047434140.1 → XP_047290096.1 multidrug resistance-associated protein 1 isoform X11

UniProtKB/TrEMBL

I3L4X2
XM_047434152.1 → XP_047290108.1 multidrug resistance-associated protein 1 isoform X21

UniProtKB/TrEMBL

Q9UQ98
XM_047434145.1 → XP_047290101.1 multidrug resistance-associated protein 1 isoform X15

UniProtKB/TrEMBL

Q9UQ98
XM_047434151.1 → XP_047290107.1 multidrug resistance-associated protein 1 isoform X20

UniProtKB/TrEMBL

Q9UQ98
XM_047434131.1 → XP_047290087.1 multidrug resistance-associated protein 1 isoform X1

UniProtKB/TrEMBL

I3L4X2
XM_047434136.1 → XP_047290092.1 multidrug resistance-associated protein 1 isoform X7

UniProtKB/TrEMBL

Q9UQ98
XM_047434144.1 → XP_047290100.1 multidrug resistance-associated protein 1 isoform X14

UniProtKB/TrEMBL

Q9UQ98
XM_047434135.1 → XP_047290091.1 multidrug resistance-associated protein 1 isoform X6

UniProtKB/TrEMBL

I3L4X2
XM_047434142.1 → XP_047290098.1 multidrug resistance-associated protein 1 isoform X13

UniProtKB/TrEMBL

Q9UQ98
XM_047434132.1 → XP_047290088.1 multidrug resistance-associated protein 1 isoform X3

UniProtKB/TrEMBL

I3L4X2
XM_047434133.1 → XP_047290089.1 multidrug resistance-associated protein 1 isoform X4

UniProtKB/TrEMBL

I3L4X2
XM_047434137.1 → XP_047290093.1 multidrug resistance-associated protein 1 isoform X9

UniProtKB/TrEMBL

Q9UQ98
XM_017023237.2 → XP_016878726.1 multidrug resistance-associated protein 1 isoform X2

UniProtKB/TrEMBL

I3L4X2
XM_011522497.2 → XP_011520799.1 multidrug resistance-associated protein 1 isoform X8

UniProtKB/TrEMBL

I3L4X2

Conserved Domains (4) summary

TIGR00957
Location:9 → 1522

MRP_assoc_pro; multi drug resistance-associated protein (MRP)

cd03244
Location:1283 → 1503

ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein

cd03250
Location:636 → 837

ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C

pfam00664
Location:971 → 1236

ABC_membrane; ABC transporter transmembrane region

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

NT_187607.1 Reference GRCh38.p14 ALT_REF_LOCI_1

Range

1607333..1800945

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054329091.1 → XP_054185066.1 multidrug resistance-associated protein 1 isoform X28

UniProtKB/TrEMBL

I3L4X2
XM_054329090.1 → XP_054185065.1 multidrug resistance-associated protein 1 isoform X27

UniProtKB/TrEMBL

I3L4X2
XM_054329085.1 → XP_054185060.1 multidrug resistance-associated protein 1 isoform X25

UniProtKB/TrEMBL

I3L4X2
XM_054329086.1 → XP_054185061.1 multidrug resistance-associated protein 1 isoform X19

UniProtKB/TrEMBL

Q9UQ98
XM_054329079.1 → XP_054185054.1 multidrug resistance-associated protein 1 isoform X12

UniProtKB/TrEMBL

I3L4X2
XM_054329084.1 → XP_054185059.1 multidrug resistance-associated protein 1 isoform X18

UniProtKB/TrEMBL

Q9UQ98
XM_054329089.1 → XP_054185064.1 multidrug resistance-associated protein 1 isoform X23

UniProtKB/TrEMBL

Q9UQ98
XM_054329077.1 → XP_054185052.1 multidrug resistance-associated protein 1 isoform X10

UniProtKB/TrEMBL

I3L4X2
XM_054329083.1 → XP_054185058.1 multidrug resistance-associated protein 1 isoform X17

UniProtKB/TrEMBL

Q9UQ98
XM_054329081.1 → XP_054185056.1 multidrug resistance-associated protein 1 isoform X16

UniProtKB/TrEMBL

I3L4X2
XM_054329078.1 → XP_054185053.1 multidrug resistance-associated protein 1 isoform X11

UniProtKB/TrEMBL

I3L4X2
XM_054329082.1 → XP_054185057.1 multidrug resistance-associated protein 1 isoform X24

UniProtKB/TrEMBL

I3L4X2
XM_054329080.1 → XP_054185055.1 multidrug resistance-associated protein 1 isoform X15

UniProtKB/TrEMBL

Q9UQ98
XM_054329088.1 → XP_054185063.1 multidrug resistance-associated protein 1 isoform X26

UniProtKB/TrEMBL

Q9UQ98
XM_054329093.1 → XP_054185068.1 multidrug resistance-associated protein 1 isoform X30

UniProtKB/TrEMBL

Q9UQ98
XM_054329087.1 → XP_054185062.1 multidrug resistance-associated protein 1 isoform X20

UniProtKB/TrEMBL

Q9UQ98
XM_054329092.1 → XP_054185067.1 multidrug resistance-associated protein 1 isoform X29

UniProtKB/TrEMBL

Q9UQ98
XM_054329072.1 → XP_054185047.1 multidrug resistance-associated protein 1 isoform X1

UniProtKB/TrEMBL

I3L4X2
XM_054329075.1 → XP_054185050.1 multidrug resistance-associated protein 1 isoform X6

UniProtKB/TrEMBL

I3L4X2
XM_054329074.1 → XP_054185049.1 multidrug resistance-associated protein 1 isoform X3

UniProtKB/TrEMBL

I3L4X2
XM_054329073.1 → XP_054185048.1 multidrug resistance-associated protein 1 isoform X2

UniProtKB/TrEMBL

I3L4X2
XM_054329076.1 → XP_054185051.1 multidrug resistance-associated protein 1 isoform X8

UniProtKB/TrEMBL

I3L4X2
XM_054329094.1 → XP_054185069.1 multidrug resistance-associated protein 1 isoform X31

UniProtKB/TrEMBL

A0A0A0MS99

Alternate T2T-CHM13v2.0

Genomic

NC_060940.1 Alternate T2T-CHM13v2.0

Range

15954068..16147908

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054380352.1 → XP_054236327.1 multidrug resistance-associated protein 1 isoform X5

UniProtKB/TrEMBL

I3L4X2
XM_054380369.1 → XP_054236344.1 multidrug resistance-associated protein 1 isoform X35

UniProtKB/TrEMBL

I3L4X2
XM_054380377.1 → XP_054236352.1 multidrug resistance-associated protein 1 isoform X38

UniProtKB/TrEMBL

I3L4X2
XM_054380376.1 → XP_054236351.1 multidrug resistance-associated protein 1 isoform X37

UniProtKB/TrEMBL

I3L4X2
XM_054380367.1 → XP_054236342.1 multidrug resistance-associated protein 1 isoform X33

UniProtKB/TrEMBL

I3L4X2
XM_054380370.1 → XP_054236345.1 multidrug resistance-associated protein 1 isoform X19

UniProtKB/TrEMBL

Q9UQ98
XM_054380359.1 → XP_054236334.1 multidrug resistance-associated protein 1 isoform X12

UniProtKB/TrEMBL

I3L4X2
XM_054380366.1 → XP_054236341.1 multidrug resistance-associated protein 1 isoform X18

UniProtKB/TrEMBL

Q9UQ98
XM_054380375.1 → XP_054236350.1 multidrug resistance-associated protein 1 isoform X23

UniProtKB/TrEMBL

Q9UQ98
XM_054380357.1 → XP_054236332.1 multidrug resistance-associated protein 1 isoform X10

UniProtKB/TrEMBL

I3L4X2
XM_054380365.1 → XP_054236340.1 multidrug resistance-associated protein 1 isoform X17

UniProtKB/TrEMBL

Q9UQ98
XM_054380374.1 → XP_054236349.1 multidrug resistance-associated protein 1 isoform X22

UniProtKB/TrEMBL

A0A7I2V2E0, Q9UQ98
XM_054380363.1 → XP_054236338.1 multidrug resistance-associated protein 1 isoform X16

UniProtKB/TrEMBL

I3L4X2
XM_054380358.1 → XP_054236333.1 multidrug resistance-associated protein 1 isoform X11

UniProtKB/TrEMBL

I3L4X2
XM_054380364.1 → XP_054236339.1 multidrug resistance-associated protein 1 isoform X32

UniProtKB/TrEMBL

I3L4X2
XM_054380373.1 → XP_054236348.1 multidrug resistance-associated protein 1 isoform X21

UniProtKB/TrEMBL

Q9UQ98
XM_054380362.1 → XP_054236337.1 multidrug resistance-associated protein 1 isoform X15

UniProtKB/TrEMBL

Q9UQ98
XM_054380372.1 → XP_054236347.1 multidrug resistance-associated protein 1 isoform X36

UniProtKB/TrEMBL

Q9UQ98
XM_054380379.1 → XP_054236354.1 multidrug resistance-associated protein 1 isoform X40

UniProtKB/TrEMBL

Q9UQ98
XM_054380371.1 → XP_054236346.1 multidrug resistance-associated protein 1 isoform X20

UniProtKB/TrEMBL

Q9UQ98
XM_054380378.1 → XP_054236353.1 multidrug resistance-associated protein 1 isoform X39

UniProtKB/TrEMBL

Q9UQ98
XM_054380348.1 → XP_054236323.1 multidrug resistance-associated protein 1 isoform X1

UniProtKB/TrEMBL

I3L4X2
XM_054380354.1 → XP_054236329.1 multidrug resistance-associated protein 1 isoform X7

UniProtKB/TrEMBL

Q9UQ98
XM_054380361.1 → XP_054236336.1 multidrug resistance-associated protein 1 isoform X14

UniProtKB/TrEMBL

Q9UQ98
XM_054380353.1 → XP_054236328.1 multidrug resistance-associated protein 1 isoform X6

UniProtKB/TrEMBL

I3L4X2
XM_054380360.1 → XP_054236335.1 multidrug resistance-associated protein 1 isoform X13

UniProtKB/TrEMBL

Q9UQ98
XM_054380368.1 → XP_054236343.1 multidrug resistance-associated protein 1 isoform X34

UniProtKB/TrEMBL

Q9UQ98
XM_054380350.1 → XP_054236325.1 multidrug resistance-associated protein 1 isoform X3

UniProtKB/TrEMBL

I3L4X2
XM_054380351.1 → XP_054236326.1 multidrug resistance-associated protein 1 isoform X4

UniProtKB/TrEMBL

I3L4X2
XM_054380356.1 → XP_054236331.1 multidrug resistance-associated protein 1 isoform X9

UniProtKB/TrEMBL

Q9UQ98
XM_054380349.1 → XP_054236324.1 multidrug resistance-associated protein 1 isoform X2

UniProtKB/TrEMBL

I3L4X2
XM_054380355.1 → XP_054236330.1 multidrug resistance-associated protein 1 isoform X8

UniProtKB/TrEMBL

I3L4X2
XM_054380380.1 → XP_054236355.1 multidrug resistance-associated protein 1 isoform X41

UniProtKB/TrEMBL

A0A0A0MS99

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_019898.2: Suppressed sequence

Description

NM_019898.2: This RefSeq was permanently suppressed because currently there is no full-length support for the transcript and the protein.
NM_019899.2: Suppressed sequence

Description

NM_019899.2: This RefSeq was permanently suppressed because currently there is no full-length support for the transcript and the protein.
NM_019900.2: Suppressed sequence

Description

NM_019900.2: This RefSeq was permanently suppressed because currently there is no full-length support for the transcript and the protein.
NM_019901.1: Suppressed sequence

Description

NM_019901.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
NM_019902.1: Suppressed sequence

Description

NM_019902.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.