Format

Send to:

Choose Destination

ABCC1 ATP binding cassette subfamily C member 1 [ Homo sapiens (human) ]

Gene ID: 4363, updated on 27-Jun-2020

Summary

Official Symbol
ABCC1provided by HGNC
Official Full Name
ATP binding cassette subfamily C member 1provided by HGNC
Primary source
HGNC:HGNC:51
See related
Ensembl:ENSG00000103222 MIM:158343
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRP; ABCC; GS-X; MRP1; ABC29; DFNA77
Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]
Expression
Ubiquitous expression in testis (RPKM 13.5), esophagus (RPKM 9.9) and 25 other tissues See more
Orthologs

Genomic context

See ABCC1 in Genome Data Viewer
Location:
16p13.11
Exon count:
34
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (15949616..16143062)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (16043434..16236931)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 213, pseudogene Neighboring gene uncharacterized LOC107984869 Neighboring gene centrosomal protein 20 Neighboring gene ribosomal protein L15 pseudogene 20 Neighboring gene Sharpr-MPRA regulatory region 4662 Neighboring gene ribosomal protein L17 pseudogene 40 Neighboring gene ATP binding cassette subfamily C member 6 Neighboring gene uncharacterized LOC105371100 Neighboring gene Sharpr-MPRA regulatory region 11301 Neighboring gene NODAL modulator 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
DEAFNESS, AUTOSOMAL DOMINANT 77
MedGen: CN282602 OMIM: 618915 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env NF-kappaB and JNK signaling are involved in gp120-induced multidrug resistance protein 1 (Mrp1) regulation during an HIV-1 associated inflammatory response PubMed
Tat tat HIV-1 Tat upregulates expression of MRP1 through activation of the mitogen-activated protein kinase signaling cascade PubMed
tat HIV-1 Tat specifically upregulates MRP1 messenger ribonucleic acid and protein expression both in brain micro vascular endothelial cells (BMEC) and astrocytes PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781G125, DKFZp686N04233

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity, coupled to transmembrane movement of substances IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity, coupled to transmembrane movement of substances TAS
Traceable Author Statement
more info
 
cobalamin-transporting ATPase activity TAS
Traceable Author Statement
more info
 
efflux transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
efflux transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
glutathione S-conjugate-exporting ATPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
glutathione transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutathione transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
lipid-transporting ATPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
xenobiotic transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
xenobiotic transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
xenobiotic transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
xenobiotic transmembrane transporting ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cellular response to amyloid-beta ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cobalamin metabolic process TAS
Traceable Author Statement
more info
 
cobalamin transport IEA
Inferred from Electronic Annotation
more info
 
export across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
export across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
glutathione transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukotriene metabolic process TAS
Traceable Author Statement
more info
 
leukotriene transport ISS
Inferred from Sequence or Structural Similarity
more info
 
phospholipid translocation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
response to drug ISS
Inferred from Sequence or Structural Similarity
more info
 
sphingolipid translocation IMP
Inferred from Mutant Phenotype
more info
PubMed 
transepithelial transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transport TAS
Traceable Author Statement
more info
 
xenobiotic transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
multidrug resistance-associated protein 1
Names
ATP-binding cassette transporter variant ABCC1delta-ex13
ATP-binding cassette transporter variant ABCC1delta-ex13&14
ATP-binding cassette transporter variant ABCC1delta-ex25
ATP-binding cassette transporter variant ABCC1delta-ex25&26
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
LTC4 transporter
glutathione-S-conjugate-translocating ATPase ABCC1
leukotriene C(4) transporter
NP_004987.2
XP_011520799.1
XP_011520800.1
XP_016878726.1
XP_016878727.1
XP_016878728.1
XP_016878729.1
XP_016878730.1
XP_016878731.1
XP_016878732.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028268.2 RefSeqGene

    Range
    5040..198477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004996.4NP_004987.2  multidrug resistance-associated protein 1

    See identical proteins and their annotated locations for NP_004987.2

    Status: REVIEWED

    Source sequence(s)
    AC025778, AC136624, X78338
    Consensus CDS
    CCDS42122.1
    UniProtKB/Swiss-Prot
    P33527
    Related
    ENSP00000382342.3, ENST00000399410.8
    Conserved Domains (4) summary
    TIGR00957
    Location:71530
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:12911511
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:644845
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:9791244
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    15949616..16143062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023237.1XP_016878726.1  multidrug resistance-associated protein 1 isoform X1

  2. XM_017023240.1XP_016878729.1  multidrug resistance-associated protein 1 isoform X6

  3. XM_017023242.1XP_016878731.1  multidrug resistance-associated protein 1 isoform X8

  4. XM_011522498.2XP_011520800.1  multidrug resistance-associated protein 1 isoform X5

    Conserved Domains (4) summary
    TIGR00957
    Location:261499
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:12601480
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:613814
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:9481213
    ABC_membrane; ABC transporter transmembrane region
  5. XM_017023238.1XP_016878727.1  multidrug resistance-associated protein 1 isoform X3

  6. XM_017023239.1XP_016878728.1  multidrug resistance-associated protein 1 isoform X4

  7. XM_017023241.1XP_016878730.1  multidrug resistance-associated protein 1 isoform X7

    Related
    ENSP00000382340.3, ENST00000399408.6
  8. XM_017023243.2XP_016878732.1  multidrug resistance-associated protein 1 isoform X9

  9. XM_011522497.1XP_011520799.1  multidrug resistance-associated protein 1 isoform X2

    Related
    ENSP00000461615.1, ENST00000572882.2
    Conserved Domains (4) summary
    TIGR00957
    Location:91522
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:12831503
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:636837
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:9711236
    ABC_membrane; ABC transporter transmembrane region

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187607.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    1607598..1800945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_019862.2: Suppressed sequence

    Description
    NM_019862.2: This RefSeq was permanently suppressed because currently there is no full-length support for the transcript and the protein.
  2. NM_019898.2: Suppressed sequence

    Description
    NM_019898.2: This RefSeq was permanently suppressed because currently there is no full-length support for the transcript and the protein.
  3. NM_019899.2: Suppressed sequence

    Description
    NM_019899.2: This RefSeq was permanently suppressed because currently there is no full-length support for the transcript and the protein.
  4. NM_019900.2: Suppressed sequence

    Description
    NM_019900.2: This RefSeq was permanently suppressed because currently there is no full-length support for the transcript and the protein.
  5. NM_019901.1: Suppressed sequence

    Description
    NM_019901.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
  6. NM_019902.1: Suppressed sequence

    Description
    NM_019902.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Support Center