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ABCC1 ATP binding cassette subfamily C member 1 [ Homo sapiens (human) ]

Gene ID: 4363, updated on 20-Jan-2019

Summary

Official Symbol
ABCC1provided by HGNC
Official Full Name
ATP binding cassette subfamily C member 1provided by HGNC
Primary source
HGNC:HGNC:51
See related
Ensembl:ENSG00000103222 MIM:158343
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRP; ABCC; GS-X; MRP1; ABC29
Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]
Expression
Ubiquitous expression in testis (RPKM 13.5), esophagus (RPKM 9.9) and 25 other tissues See more
Orthologs

Genomic context

See ABCC1 in Genome Data Viewer
Location:
16p13.11
Exon count:
34
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (15949577..16143074)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (16043434..16236931)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 213, pseudogene Neighboring gene uncharacterized LOC107984869 Neighboring gene FGFR1OP N-terminal like Neighboring gene ribosomal protein L15 pseudogene 20 Neighboring gene ribosomal protein L17 pseudogene 40 Neighboring gene ATP binding cassette subfamily C member 6 Neighboring gene uncharacterized LOC105371100 Neighboring gene NODAL modulator 3 Neighboring gene uncharacterized LOC105371099

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env NF-kappaB and JNK signaling are involved in gp120-induced multidrug resistance protein 1 (Mrp1) regulation during an HIV-1 associated inflammatory response PubMed
Tat tat HIV-1 Tat upregulates expression of MRP1 through activation of the mitogen-activated protein kinase signaling cascade PubMed
tat HIV-1 Tat specifically upregulates MRP1 messenger ribonucleic acid and protein expression both in brain micro vascular endothelial cells (BMEC) and astrocytes PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • ABC transporters, organism-specific biosystem (from KEGG)
    ABC transporters, organism-specific biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • ABC transporters, conserved biosystem (from KEGG)
    ABC transporters, conserved biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • ABC-family proteins mediated transport, organism-specific biosystem (from REACTOME)
    ABC-family proteins mediated transport, organism-specific biosystemThe ATP-binding cassette (ABC) superfamily of active transporters involves a large number of functionally diverse transmembrane proteins. They transport a variety of compounds through membranes agai...
  • Antifolate resistance, organism-specific biosystem (from KEGG)
    Antifolate resistance, organism-specific biosystemSince the 1940s, antifolates have played a pivotal role in drug treatment of malignant, microbial, parasitic and chronic inflammatory diseases. The molecular basis of the anti-proliferative activity ...
  • Antifolate resistance, conserved biosystem (from KEGG)
    Antifolate resistance, conserved biosystemSince the 1940s, antifolates have played a pivotal role in drug treatment of malignant, microbial, parasitic and chronic inflammatory diseases. The molecular basis of the anti-proliferative activity ...
  • Arachidonic acid metabolism, organism-specific biosystem (from REACTOME)
    Arachidonic acid metabolism, organism-specific biosystemEicosanoids, oxygenated, 20-carbon fatty acids, are autocrine and paracrine signaling molecules that modulate physiological processes including pain, fever, inflammation, blood clot formation, smooth...
  • Cobalamin (Cbl, vitamin B12) transport and metabolism, organism-specific biosystem (from REACTOME)
    Cobalamin (Cbl, vitamin B12) transport and metabolism, organism-specific biosystemVitamin B12 (cobalamin, Cbl) is a water-soluble vitamin with a key role in blood formation and normal functioning of the brain and nervous system. Cbl consists of a planar corrin ring coordinating wi...
  • Irinotecan Pathway, organism-specific biosystem (from WikiPathways)
    Irinotecan Pathway, organism-specific biosystemThis pathway shows the biotransformation of the chemotherapy prodrug irinotecan to form the active metabolite SN-38, an inhibitor of DNA topoisomerase I. SN-38 is primarily metabolized to the inactiv...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Metabolism of vitamins and cofactors, organism-specific biosystem (from REACTOME)
    Metabolism of vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, classified according to their solubility, either fat-soluble or water-soluble, that are either not synthesized or synthesized only in limited amount...
  • Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem (from REACTOME)
    Metabolism of water-soluble vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, required in small amounts in the diet. They have distinct biochemical roles, often as coenzymes, and are either not synthesized or synthesized only ...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • S1P1 pathway, organism-specific biosystem (from Pathway Interaction Database)
    S1P1 pathway, organism-specific biosystem
    S1P1 pathway
  • Sphingolipid signaling pathway, organism-specific biosystem (from KEGG)
    Sphingolipid signaling pathway, organism-specific biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
  • Sphingolipid signaling pathway, conserved biosystem (from KEGG)
    Sphingolipid signaling pathway, conserved biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
  • Sphingosine 1-phosphate (S1P) pathway, organism-specific biosystem (from Pathway Interaction Database)
    Sphingosine 1-phosphate (S1P) pathway, organism-specific biosystem
    Sphingosine 1-phosphate (S1P) pathway
  • Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystem (from REACTOME)
    Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystemLeukotrienes (LTs) are biologically active molecules formed in response to inflammatory stimuli. They cause contraction of bronchial smooth muscles, stimulation of vascular permeability, and attracti...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
  • Vitamin digestion and absorption, organism-specific biosystem (from KEGG)
    Vitamin digestion and absorption, organism-specific biosystemVitamins are a diverse and chemically unrelated group of organic substances that share a common feature of being essential for normal health and well-being. They catalyze numerous biochemical reactio...
  • Vitamin digestion and absorption, conserved biosystem (from KEGG)
    Vitamin digestion and absorption, conserved biosystemVitamins are a diverse and chemically unrelated group of organic substances that share a common feature of being essential for normal health and well-being. They catalyze numerous biochemical reactio...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781G125, DKFZp686N04233

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity, coupled to transmembrane movement of substances IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity, coupled to transmembrane movement of substances TAS
Traceable Author Statement
more info
 
ATPase-coupled anion transmembrane transporter activity TAS
Traceable Author Statement
more info
 
cobalamin-transporting ATPase activity TAS
Traceable Author Statement
more info
 
glutathione transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid-translocating ATPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
sphingolipid-translocating ATPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transporter activity TAS
Traceable Author Statement
more info
PubMed 
xenobiotic transmembrane transporting ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
ATP hydrolysis coupled anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cobalamin metabolic process TAS
Traceable Author Statement
more info
 
cobalamin transport IEA
Inferred from Electronic Annotation
more info
 
drug transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutathione transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukotriene metabolic process TAS
Traceable Author Statement
more info
 
phospholipid translocation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to drug TAS
Traceable Author Statement
more info
PubMed 
sphingolipid translocation IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transport TAS
Traceable Author Statement
more info
 
xenobiotic transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
multidrug resistance-associated protein 1
Names
ATP-binding cassette transporter variant ABCC1delta-ex13
ATP-binding cassette transporter variant ABCC1delta-ex13&14
ATP-binding cassette transporter variant ABCC1delta-ex25
ATP-binding cassette transporter variant ABCC1delta-ex25&26
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
LTC4 transporter
leukotriene C(4) transporter

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028268.2 RefSeqGene

    Range
    5001..198498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004996.4NP_004987.2  multidrug resistance-associated protein 1

    See identical proteins and their annotated locations for NP_004987.2

    Status: REVIEWED

    Source sequence(s)
    AC025778, AC136624, X78338
    Consensus CDS
    CCDS42122.1
    UniProtKB/Swiss-Prot
    P33527
    Related
    ENSP00000382342.3, ENST00000399410.7
    Conserved Domains (4) summary
    TIGR00957
    Location:71530
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:12911511
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:644845
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:9791244
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    15949577..16143074
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023237.1XP_016878726.1  multidrug resistance-associated protein 1 isoform X1

  2. XM_017023240.1XP_016878729.1  multidrug resistance-associated protein 1 isoform X6

  3. XM_017023242.1XP_016878731.1  multidrug resistance-associated protein 1 isoform X8

  4. XM_011522498.2XP_011520800.1  multidrug resistance-associated protein 1 isoform X5

    Conserved Domains (4) summary
    TIGR00957
    Location:261499
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:12601480
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:613814
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:9481213
    ABC_membrane; ABC transporter transmembrane region
  5. XM_017023238.1XP_016878727.1  multidrug resistance-associated protein 1 isoform X3

  6. XM_017023239.1XP_016878728.1  multidrug resistance-associated protein 1 isoform X4

  7. XM_017023241.1XP_016878730.1  multidrug resistance-associated protein 1 isoform X7

    Related
    ENSP00000382340.3, ENST00000399408.6
  8. XM_017023243.2XP_016878732.1  multidrug resistance-associated protein 1 isoform X9

  9. XM_011522497.1XP_011520799.1  multidrug resistance-associated protein 1 isoform X2

    Related
    ENSP00000461615.1, ENST00000572882.2
    Conserved Domains (4) summary
    TIGR00957
    Location:91522
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:12831503
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:636837
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:9711236
    ABC_membrane; ABC transporter transmembrane region

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187607.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    1665690..1800966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_019862.2: Suppressed sequence

    Description
    NM_019862.2: This RefSeq was permanently suppressed because currently there is no full-length support for the transcript and the protein.
  2. NM_019898.2: Suppressed sequence

    Description
    NM_019898.2: This RefSeq was permanently suppressed because currently there is no full-length support for the transcript and the protein.
  3. NM_019899.2: Suppressed sequence

    Description
    NM_019899.2: This RefSeq was permanently suppressed because currently there is no full-length support for the transcript and the protein.
  4. NM_019900.2: Suppressed sequence

    Description
    NM_019900.2: This RefSeq was permanently suppressed because currently there is no full-length support for the transcript and the protein.
  5. NM_019901.1: Suppressed sequence

    Description
    NM_019901.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
  6. NM_019902.1: Suppressed sequence

    Description
    NM_019902.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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