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Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [ Mus musculus (house mouse) ]

Gene ID: 17250, updated on 8-Dec-2022

Summary

Official Symbol
Abcc1provided by MGI
Official Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 1provided by MGI
Primary source
MGI:MGI:102676
See related
Ensembl:ENSMUSG00000023088 AllianceGenome:MGI:102676
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MRP; Mrp1; Mdrap; Abcc1a; Abcc1b
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein plays an essential role in the defense against toxic compounds and serves as the major high-affinity transporter of leukotriene C4. The encoded protein may also play an essential role in steroid hormone homeostasis as a transporter for steroid hormones and their metabolites. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 11.9), genital fat pad adult (RPKM 10.8) and 27 other tissues See more
Orthologs
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Genomic context

See Abcc1 in Genome Data Viewer
Location:
16; 16 A1
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (14179317..14292743)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (14361453..14474878)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene myosin, heavy polypeptide 11, smooth muscle Neighboring gene centrosomal protein 20 Neighboring gene predicted gene, 23116 Neighboring gene RIKEN cDNA A630010A05 gene Neighboring gene uncharacterized LOC115488637

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type glutathione S-conjugate transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ABC-type transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ABC-type vitamin B12 transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ABC-type vitamin B12 transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ABC-type xenobiotic transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ABC-type xenobiotic transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled lipid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables amide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables carboxylic acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables efflux transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables efflux transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables glutathione transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutathione transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables glutathione transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acid transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables xenobiotic transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables xenobiotic transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in carboxylic acid transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amyloid-beta IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cobalamin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in export across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in glutathione transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glutathione transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in leukotriene transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in long-chain fatty acid import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid translocation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in sphingolipid translocation ISO
Inferred from Sequence Orthology
more info
 
involved_in transepithelial transport ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in xenobiotic transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in xenobiotic transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in xenobiotic transport ISO
Inferred from Sequence Orthology
more info
 
involved_in xenobiotic transport across blood-brain barrier ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in basal plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
multidrug resistance-associated protein 1
Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 1a
ATP-binding cassette, sub-family C (CFTR/MRP), member 1b
LTC4 transporter
glutathione-S-conjugate-translocating ATPase ABCC1
leukotriene C(4) transporter
multiple drug resistance-associated protein
NP_032602.1
XP_006521902.2
XP_017172377.1
XP_036015706.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008576.3NP_032602.1  multidrug resistance-associated protein 1

    See identical proteins and their annotated locations for NP_032602.1

    Status: REVIEWED

    Source sequence(s)
    AK029876, BC090617, BP762240
    Consensus CDS
    CCDS37264.1
    UniProtKB/Swiss-Prot
    O35379
    UniProtKB/TrEMBL
    A5D6P3
    Related
    ENSMUSP00000097743.4, ENSMUST00000100167.10
    Conserved Domains (1) summary
    TIGR00957
    Location:71527
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    14179317..14292743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521839.5XP_006521902.2  multidrug resistance-associated protein 1 isoform X1

    Conserved Domains (1) summary
    TIGR00957
    Location:71518
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
  2. XM_017316888.2XP_017172377.1  multidrug resistance-associated protein 1 isoform X2

    Related
    ENSMUSP00000116714.2, ENSMUST00000130671.8
    Conserved Domains (1) summary
    TIGR00957
    Location:7773
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
  3. XM_036159813.1XP_036015706.1  multidrug resistance-associated protein 1 isoform X3

    Conserved Domains (1) summary
    TIGR00957
    Location:1787
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)

RNA

  1. XR_004939170.1 RNA Sequence