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MPP2 membrane palmitoylated protein 2 [ Homo sapiens (human) ]

Gene ID: 4355, updated on 8-Oct-2017
Official Symbol
MPP2provided by HGNC
Official Full Name
membrane palmitoylated protein 2provided by HGNC
Primary source
HGNC:HGNC:7220
See related
Ensembl:ENSG00000108852 MIM:600723; Vega:OTTHUMG00000133840
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DLG2
Summary
Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. [provided by RefSeq, Jul 2008]
Orthologs
Location:
17q21.31
Exon count:
19
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (43875357..43909711, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41952727..41987079, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984979 Neighboring gene uncharacterized LOC107985077 Neighboring gene CD300 molecule like family member g Neighboring gene uncharacterized LOC105371787 Neighboring gene uncharacterized LOC107985086 Neighboring gene family with sequence similarity 215 member A (non-protein coding)

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

NHGRI GWAS Catalog

Description
Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2, MPP2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp686J2189, DKFZp761D0712, DKFZp686A06252

Gene Ontology Provided by GOA

Function Evidence Code Pubs
guanylate kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
GDP metabolic process IEA
Inferred from Electronic Annotation
more info
 
GMP metabolic process IEA
Inferred from Electronic Annotation
more info
 
excitatory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
 
long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homooligomerization ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
dendrite membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic shaft ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
MAGUK p55 subfamily member 2
Names
discs large, homolog 2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278370.1NP_001265299.1  MAGUK p55 subfamily member 2 isoform 1

    See identical proteins and their annotated locations for NP_001265299.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC007993, AK295858, AL136554, DC321822
    Consensus CDS
    CCDS62210.1
    UniProtKB/Swiss-Prot
    Q14168
    UniProtKB/TrEMBL
    A0A0C4DH75
    Related
    ENSP00000428182.1, OTTHUMP00000227528, ENST00000518766.5, OTTHUMT00000380313
    Conserved Domains (6) summary
    smart00569
    Location:58111
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:274332
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:404585
    GuKc; Guanylate kinase homologues
    cd00992
    Location:183261
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:394584
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:113164
    L27; L27 domain
  2. NM_001278371.1NP_001265300.1  MAGUK p55 subfamily member 2 isoform 2

    See identical proteins and their annotated locations for NP_001265300.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2, 5, and 7 encode the same protein.
    Source sequence(s)
    AC007993, AK295858, AL136554, DC321822, DC333563
    Consensus CDS
    CCDS62207.1
    UniProtKB/Swiss-Prot
    Q14168
    UniProtKB/TrEMBL
    B4DZ84
    Related
    ENSP00000480071.1, ENST00000622681.4
    Conserved Domains (6) summary
    smart00569
    Location:255
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:218276
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:348529
    GuKc; Guanylate kinase homologues
    cd00992
    Location:127205
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:338528
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57108
    L27; L27 domain
  3. NM_001278372.1NP_001265301.1  MAGUK p55 subfamily member 2 isoform 4

    See identical proteins and their annotated locations for NP_001265301.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) includes an alternate coding exon and represents use of an alternate promoter, compared to variant 1. It encodes isoform 4 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC007993, AK299286, AL136554, DC302184, X82895
    Consensus CDS
    CCDS62209.1
    UniProtKB/Swiss-Prot
    Q14168
    UniProtKB/TrEMBL
    D3DX49
    Related
    ENSP00000428286.1, OTTHUMP00000227525, ENST00000461854.5, OTTHUMT00000258388
    Conserved Domains (6) summary
    smart00569
    Location:1390
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:253311
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:383564
    GuKc; Guanylate kinase homologues
    cd00992
    Location:162240
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:373563
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:92143
    L27; L27 domain
  4. NM_001278373.1NP_001265302.1  MAGUK p55 subfamily member 2 isoform 2

    See identical proteins and their annotated locations for NP_001265302.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon and represents use of an alternate promoter, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2, 5, and 7 encode the same protein.
    Source sequence(s)
    AC007993, AK299286, AL136554, DC302184
    Consensus CDS
    CCDS62207.1
    UniProtKB/Swiss-Prot
    Q14168
    UniProtKB/TrEMBL
    B4DZ84
    Related
    ENSP00000430540.1, OTTHUMP00000227527, ENST00000523501.5, OTTHUMT00000380312
    Conserved Domains (6) summary
    smart00569
    Location:255
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:218276
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:348529
    GuKc; Guanylate kinase homologues
    cd00992
    Location:127205
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:338528
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57108
    L27; L27 domain
  5. NM_001278374.1NP_001265303.1  MAGUK p55 subfamily member 2 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an in-frame coding exon and represents use of an alternate promoter, compared to variant 1. It encodes isoform 6 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC007993, AK294564, AL136554, DC302184
    Consensus CDS
    CCDS62206.1
    UniProtKB/Swiss-Prot
    Q14168
    Related
    ENSP00000428136.1, OTTHUMP00000227526, ENST00000520305.5, OTTHUMT00000380311
    Conserved Domains (4) summary
    cd12037
    Location:90148
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:220401
    GuKc; Guanylate kinase homologues
    cd00992
    Location:177
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:210400
    Guanylate_kin; Guanylate kinase
  6. NM_001278375.1NP_001265304.1  MAGUK p55 subfamily member 2 isoform 2

    See identical proteins and their annotated locations for NP_001265304.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2, 5, and 7 encode the same protein.
    Source sequence(s)
    AC007993, AK302793, AL136554
    Consensus CDS
    CCDS62207.1
    UniProtKB/Swiss-Prot
    Q14168
    UniProtKB/TrEMBL
    B4DZ84
    Related
    ENSP00000438012.1, ENST00000536246.5
    Conserved Domains (6) summary
    smart00569
    Location:255
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:218276
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:348529
    GuKc; Guanylate kinase homologues
    cd00992
    Location:127205
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:338528
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57108
    L27; L27 domain
  7. NM_001278376.2NP_001265305.2  MAGUK p55 subfamily member 2 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. It encodes isoform 8 which has a distinct N-terminus and is shorter, compared to isoform 1.
    Source sequence(s)
    AC007993, AK299321, AL136554, DC347918
    Consensus CDS
    CCDS62208.1
    UniProtKB/Swiss-Prot
    Q14168
    UniProtKB/TrEMBL
    A0A0A0MRU0, B4DRL7
    Related
    ENSP00000366389.3, OTTHUMP00000165333, ENST00000377184.7, OTTHUMT00000258387
    Conserved Domains (6) summary
    smart00569
    Location:3083
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:246304
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:376557
    GuKc; Guanylate kinase homologues
    cd00992
    Location:155233
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:366556
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:85136
    L27; L27 domain
  8. NM_001278381.1NP_001265310.1  MAGUK p55 subfamily member 2 isoform 3

    See identical proteins and their annotated locations for NP_001265310.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Variants 3 and 9 encode isoform 3 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC007993, AK299286, AL136554, DC302184, DC399913
    Consensus CDS
    CCDS11471.1
    UniProtKB/Swiss-Prot
    Q14168
    UniProtKB/TrEMBL
    D3DX48
    Related
    ENSP00000478528.1, ENST00000612133.4
    Conserved Domains (5) summary
    smart00569
    Location:1366
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:229287
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:359540
    GuKc; Guanylate kinase homologues
    cd00992
    Location:138216
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:68119
    L27; L27 domain
  9. NM_005374.4NP_005365.4  MAGUK p55 subfamily member 2 isoform 3

    See identical proteins and their annotated locations for NP_005365.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Variants 3 and 9 encode isoform 3 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC007993, AK223560, AK299286, AL136554, DC302184
    Consensus CDS
    CCDS11471.1
    UniProtKB/Swiss-Prot
    Q14168
    UniProtKB/TrEMBL
    D3DX48
    Related
    ENSP00000269095.4, OTTHUMP00000165332, ENST00000269095.8, OTTHUMT00000258386
    Conserved Domains (5) summary
    smart00569
    Location:1366
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:229287
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:359540
    GuKc; Guanylate kinase homologues
    cd00992
    Location:138216
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:68119
    L27; L27 domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

    Range
    43875357..43909711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524827.2XP_011523129.2  MAGUK p55 subfamily member 2 isoform X1

RNA

  1. XR_001752511.1 RNA Sequence

  2. XR_001752510.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    42188320..42222639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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