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Mpp2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) [ Mus musculus (house mouse) ]

Gene ID: 50997, updated on 5-Mar-2024

Summary

Official Symbol
Mpp2provided by MGI
Official Full Name
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)provided by MGI
Primary source
MGI:MGI:1858257
See related
Ensembl:ENSMUSG00000017314 AllianceGenome:MGI:1858257
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dlg2; Dlgh2; Pals4; D11Bwg0652e
Summary
Enables transmembrane transporter binding activity. A structural constituent of postsynaptic density. Involved in excitatory postsynaptic potential and long-term synaptic potentiation. Located in dendrite and glutamatergic synapse. Is anchored component of postsynaptic density membrane. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut gland; respiratory system; and retina. Orthologous to human MPP2 (MAGUK p55 scaffold protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 33.8), cortex adult (RPKM 27.2) and 20 other tissues See more
Orthologs
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Genomic context

See Mpp2 in Genome Data Viewer
Location:
11 D; 11 65.48 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101947841..101979464, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102057015..102088638, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) Neighboring gene CD300 molecule like family member G Neighboring gene predicted gene, 39393 Neighboring gene pancreatic polypeptide Neighboring gene peptide YY

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic shaft IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
MAGUK p55 subfamily member 2
Names
discs large homolog 2
p55 subfamily member of MAGUK family

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356324.2NP_001343253.1  MAGUK p55 subfamily member 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591145
    Consensus CDS
    CCDS88261.1
    Related
    ENSMUSP00000097967.5, ENSMUST00000100398.5
    Conserved Domains (5) summary
    smart00569
    Location:3083
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:246304
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:376557
    GuKc; Guanylate kinase homologues
    cd00992
    Location:155233
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:85136
    L27; L27 domain
  2. NM_001414216.1NP_001401145.1  MAGUK p55 subfamily member 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL591145
    UniProtKB/Swiss-Prot
    B1AQF8, Q3T9W1, Q3TT52, Q3URK8, Q9WV34
  3. NM_001414217.1NP_001401146.1  MAGUK p55 subfamily member 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL591145
    UniProtKB/Swiss-Prot
    B1AQF8, Q3T9W1, Q3TT52, Q3URK8, Q9WV34
  4. NM_001414218.1NP_001401147.1  MAGUK p55 subfamily member 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL591145
    UniProtKB/Swiss-Prot
    B1AQF8, Q3T9W1, Q3TT52, Q3URK8, Q9WV34
  5. NM_001414219.1NP_001401148.1  MAGUK p55 subfamily member 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL591145
    UniProtKB/Swiss-Prot
    B1AQF8, Q3T9W1, Q3TT52, Q3URK8, Q9WV34
  6. NM_001414220.1NP_001401149.1  MAGUK p55 subfamily member 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL591145
  7. NM_001414221.1NP_001401150.1  MAGUK p55 subfamily member 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL591145
  8. NM_016695.5NP_057904.1  MAGUK p55 subfamily member 2 isoform 2

    See identical proteins and their annotated locations for NP_057904.1

    Status: VALIDATED

    Source sequence(s)
    AL591145
    Consensus CDS
    CCDS25485.1
    UniProtKB/Swiss-Prot
    B1AQF8, Q3T9W1, Q3TT52, Q3URK8, Q9WV34
    Related
    ENSMUSP00000017458.4, ENSMUST00000017458.11
    Conserved Domains (5) summary
    smart00569
    Location:1366
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:229287
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:359540
    GuKc; Guanylate kinase homologues
    cd00992
    Location:138216
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:68119
    L27; L27 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    101947841..101979464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246119.2XP_030101979.1  MAGUK p55 subfamily member 2 isoform X4

    Conserved Domains (3) summary
    cd12037
    Location:90148
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:220401
    GuKc; Guanylate kinase homologues
    cd00992
    Location:177
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. XM_036156826.1XP_036012719.1  MAGUK p55 subfamily member 2 isoform X4

    Conserved Domains (3) summary
    cd12037
    Location:90148
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:220401
    GuKc; Guanylate kinase homologues
    cd00992
    Location:177
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. XM_030246120.2XP_030101980.1  MAGUK p55 subfamily member 2 isoform X4

    Conserved Domains (3) summary
    cd12037
    Location:90148
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:220401
    GuKc; Guanylate kinase homologues
    cd00992
    Location:177
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  4. XM_036156825.1XP_036012718.1  MAGUK p55 subfamily member 2 isoform X3

    Conserved Domains (5) summary
    smart00569
    Location:1366
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:229287
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:359496
    GuKc; Guanylate kinase homologues
    cd00992
    Location:138216
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:68119
    L27; L27 domain
  5. XM_036156827.1XP_036012720.1  MAGUK p55 subfamily member 2 isoform X5

    Conserved Domains (3) summary
    cd12037
    Location:90148
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:220357
    GuKc; Guanylate kinase homologues
    cd00992
    Location:177
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...