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MPO myeloperoxidase [ Homo sapiens (human) ]

Gene ID: 4353, updated on 23-Jan-2022

Summary

Official Symbol
MPOprovided by HGNC
Official Full Name
myeloperoxidaseprovided by HGNC
Primary source
HGNC:HGNC:7218
See related
Ensembl:ENSG00000005381 MIM:606989
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
Expression
Restricted expression toward bone marrow (RPKM 1596.3) See more
Orthologs
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Genomic context

See MPO in Genome Data Viewer
Location:
17q22
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (58269855..58280935, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (56347216..56358296, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371841 Neighboring gene lactoperoxidase Neighboring gene enhancer region in introns 7-9 of MPO Neighboring gene MPO proximal enhancer and promoter region Neighboring gene MPO upstream enhancer region Neighboring gene Sharpr-MPRA regulatory region 10051 Neighboring gene TSPO associated protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Alzheimer disease
MedGen: C0002395 OMIM: 104300 GeneReviews: Alzheimer Disease Overview
Compare labs
Myeloperoxidase deficiency
MedGen: C0398595 OMIM: 254600 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of myeloperoxidase (MPO) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates myeloperoxidase in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding TAS
Traceable Author Statement
more info
PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in aging IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response TAS
Traceable Author Statement
more info
PubMed 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to fungus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hypochlorous acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in low-density lipoprotein particle remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in removal of superoxide radicals IEA
Inferred from Electronic Annotation
more info
 
involved_in respiratory burst involved in defense response IEA
Inferred from Electronic Annotation
more info
 
involved_in response to food IEA
Inferred from Electronic Annotation
more info
 
involved_in response to gold nanoparticle IEA
Inferred from Electronic Annotation
more info
 
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to oxidative stress TAS
Traceable Author Statement
more info
PubMed 
involved_in response to yeast IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009629.1 RefSeqGene

    Range
    5001..16080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_84

mRNA and Protein(s)

  1. NM_000250.2NP_000241.1  myeloperoxidase precursor

    See identical proteins and their annotated locations for NP_000241.1

    Status: REVIEWED

    Source sequence(s)
    AC004687, M19507
    Consensus CDS
    CCDS11604.1
    UniProtKB/Swiss-Prot
    P05164
    Related
    ENSP00000225275.3, ENST00000225275.4
    Conserved Domains (1) summary
    cd09824
    Location:316728
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    58269855..58280935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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