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Mpo myeloperoxidase [ Mus musculus (house mouse) ]

Gene ID: 17523, updated on 8-May-2022

Summary

Official Symbol
Mpoprovided by MGI
Official Full Name
myeloperoxidaseprovided by MGI
Primary source
MGI:MGI:97137
See related
Ensembl:ENSMUSG00000009350 AllianceGenome:MGI:97137
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA4033
Summary
Enables peroxidase activity. Acts upstream of or within several processes, including hypochlorous acid biosynthetic process; removal of superoxide radicals; and response to fungus. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; integumental system; and skeleton. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 1; cystic fibrosis; kidney failure (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human MPO (myeloperoxidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14.5 (RPKM 72.3), liver E14 (RPKM 65.9) and 2 other tissues See more
Orthologs
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Genomic context

See Mpo in Genome Data Viewer
Location:
11 52.22 cM; 11 C
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87684610..87695238)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87793784..87804412)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (87607286..87617914)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene TSPO associated protein 1 Neighboring gene Mpo distal enhancer region Neighboring gene Mpo proximal enhancer and promoter region Neighboring gene lactoperoxidase Neighboring gene MKS transition zone complex subunit 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4033

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peroxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in azurophil granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010824.2NP_034954.2  myeloperoxidase precursor

    See identical proteins and their annotated locations for NP_034954.2

    Status: VALIDATED

    Source sequence(s)
    AK220229, BC053912, BY352425, CA547566, CN661559
    Consensus CDS
    CCDS25217.1
    UniProtKB/Swiss-Prot
    P11247
    UniProtKB/TrEMBL
    Q571G0, Q7TMS4
    Related
    ENSMUSP00000020779.5, ENSMUST00000020779.11
    Conserved Domains (2) summary
    cd09824
    Location:289702
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases
    pfam03098
    Location:147685
    An_peroxidase; Animal haem peroxidase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    87684610..87695238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)