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MNT MAX network transcriptional repressor [ Homo sapiens (human) ]

Gene ID: 4335, updated on 14-Mar-2020

Summary

Official Symbol
MNTprovided by HGNC
Official Full Name
MAX network transcriptional repressorprovided by HGNC
Primary source
HGNC:HGNC:7188
See related
Ensembl:ENSG00000070444 MIM:603039
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ROX; MAD6; MXD6; bHLHd3; lncRNA-HAL
Summary
The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 4.9), bone marrow (RPKM 4.7) and 25 other tissues See more
Orthologs

Genomic context

See MNT in Genome Data Viewer
Location:
17p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (2384073..2401060, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (2287354..2304258, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 91A Neighboring gene TSR1 ribosome maturation factor Neighboring gene small G protein signaling modulator 2 Neighboring gene uncharacterized LOC101927864 Neighboring gene ZFP161 motif-containing MPRA enhancer 161/162 Neighboring gene uncharacterized LOC284009 Neighboring gene methyltransferase like 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell aging IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
negative regulation of apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
max-binding protein MNT
Names
MAX binding protein
MNT, MAX dimerization protein
Max-interacting protein
class D basic helix-loop-helix protein 3
myc antagonist MNT

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020310.3NP_064706.1  max-binding protein MNT

    See identical proteins and their annotated locations for NP_064706.1

    Status: REVIEWED

    Source sequence(s)
    AC006435, BM469815, BM820333, BM876168, BM876428, BQ675978, CA950091, CN428911, CN428913, X96401
    Consensus CDS
    CCDS11018.1
    UniProtKB/Swiss-Prot
    Q99583
    Related
    ENSP00000174618.4, ENST00000174618.5
    Conserved Domains (1) summary
    pfam00010
    Location:222272
    HLH; Helix-loop-helix DNA-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    2384073..2401060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523868.2XP_011522170.1  max-binding protein MNT isoform X1

    Conserved Domains (1) summary
    pfam00010
    Location:230280
    HLH; Helix-loop-helix DNA-binding domain
  2. XM_024450759.1XP_024306527.1  max-binding protein MNT isoform X2

    Conserved Domains (1) summary
    cl25732
    Location:691
    SMC_N; RecF/RecN/SMC N terminal domain
  3. XM_024450758.1XP_024306526.1  max-binding protein MNT isoform X2

    Conserved Domains (1) summary
    cl25732
    Location:691
    SMC_N; RecF/RecN/SMC N terminal domain
  4. XM_011523869.2XP_011522171.1  max-binding protein MNT isoform X2

    See identical proteins and their annotated locations for XP_011522171.1

    Conserved Domains (1) summary
    cl25732
    Location:691
    SMC_N; RecF/RecN/SMC N terminal domain
  5. XM_017024654.2XP_016880143.1  max-binding protein MNT isoform X2

    Conserved Domains (1) summary
    cl25732
    Location:691
    SMC_N; RecF/RecN/SMC N terminal domain
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