U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tmprss9 transmembrane protease, serine 9 [ Mus musculus (house mouse) ]

Gene ID: 432478, updated on 27-Nov-2024

Summary

Official Symbol
Tmprss9provided by MGI
Official Full Name
transmembrane protease, serine 9provided by MGI
Primary source
MGI:MGI:3612246
See related
Ensembl:ENSMUSG00000059406 AllianceGenome:MGI:3612246
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Serase-1B
Summary
Enables serine-type peptidase activity. Acts upstream of or within plasminogen activation. Predicted to be located in plasma membrane. Used to study autism spectrum disorder. Orthologous to human TMPRSS9 (transmembrane serine protease 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in stomach adult (RPKM 19.4), testis adult (RPKM 1.4) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Tmprss9 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80706951..80735329)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80871117..80899495)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6885 Neighboring gene LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene signal peptide peptidase like 2B Neighboring gene translocase of inner mitochondrial membrane 13 Neighboring gene lamin B2 Neighboring gene STARR-positive B cell enhancer ABC_E721 Neighboring gene growth arrest and DNA-damage-inducible 45 beta

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables serine-type peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within plasminogen activation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protease serine 9
Names
polyserase-1
polyserase-I
polyserine protease-1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081688.2NP_001075157.2  transmembrane protease serine 9

    Status: VALIDATED

    Source sequence(s)
    AC152413, AC166937
    Consensus CDS
    CCDS48641.1
    UniProtKB/TrEMBL
    B2RY54, D3YTR8
    Related
    ENSMUSP00000100970.3, ENSMUST00000105333.3
    Conserved Domains (4) summary
    smart00020
    Location:238467
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:190225
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:239467
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:68148
    SEA; SEA domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80706951..80735329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513843.2XP_006513906.2  transmembrane protease serine 9 isoform X2

    UniProtKB/TrEMBL
    B2RY54
    Conserved Domains (4) summary
    smart00020
    Location:748976
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:407442
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:10771328
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:285365
    SEA; SEA domain
  2. XM_006513842.2XP_006513905.2  transmembrane protease serine 9 isoform X1

    UniProtKB/TrEMBL
    B2RY54
    Conserved Domains (4) summary
    smart00020
    Location:455684
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:407442
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:10851336
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:285365
    SEA; SEA domain
  3. XM_006513845.2XP_006513908.2  transmembrane protease serine 9 isoform X4

    UniProtKB/TrEMBL
    B2RY54
    Conserved Domains (4) summary
    smart00020
    Location:455684
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:407442
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:10851310
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:285365
    SEA; SEA domain
  4. XM_006513844.2XP_006513907.2  transmembrane protease serine 9 isoform X3

    UniProtKB/TrEMBL
    B2RY54
    Conserved Domains (3) summary
    smart00020
    Location:441670
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:393428
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01390
    Location:285365
    SEA; SEA domain