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TMPRSS9 transmembrane serine protease 9 [ Homo sapiens (human) ]

Gene ID: 360200, updated on 23-Nov-2021

Summary

Official Symbol
TMPRSS9provided by HGNC
Official Full Name
transmembrane serine protease 9provided by HGNC
Primary source
HGNC:HGNC:30079
See related
Ensembl:ENSG00000178297 MIM:610477
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a membrane-bound type II serine polyprotease that is cleaved to release three different proteases. Two of the proteases are active and can be inhibited by serine protease inhibitors, and one is thought to be catalytically inactive. This gene enhances the invasive capability of pancreatic cancer cells and may be involved in cancer progression. [provided by RefSeq, Jul 2016]
Expression
Broad expression in spleen (RPKM 1.4), testis (RPKM 1.2) and 25 other tissues See more
Orthologs
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Genomic context

See TMPRSS9 in Genome Data Viewer
Location:
19p13.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (2360265..2426261)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2385263..2426259)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene leucine rich repeat and Ig domain containing 3 Neighboring gene uncharacterized LOC101928572 Neighboring gene LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene signal peptide peptidase like 2B Neighboring gene origin of replication adjacent to lamin B2 Neighboring gene translocase of inner mitochondrial membrane 13 Neighboring gene lamin B2 Neighboring gene microRNA 7108

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
TMPRSS9 and GRIN2B are associated with neuroticism: a genome-wide association study in a European sample.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16193

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protease serine 9
Names
polyserase-1
polyserase-I
polyserine protease 1
transmembrane protease, serine 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385642.1NP_001372571.1  transmembrane protease serine 9 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC011522, AC011542
    Conserved Domains (2) summary
    smart00020
    Location:4233
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:629855
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_001395513.1NP_001382442.1  transmembrane protease serine 9 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC004410, AC011522, AC011542
    Conserved Domains (4) summary
    smart00020
    Location:236465
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:188223
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:8611087
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:66127
    SEA; SEA domain
  3. NM_182973.3NP_892018.1  transmembrane protease serine 9 isoform 1

    See identical proteins and their annotated locations for NP_892018.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC011522, AC011542
    Consensus CDS
    CCDS12088.1
    UniProtKB/Swiss-Prot
    Q7Z410
    UniProtKB/TrEMBL
    Q0X0F2
    Related
    ENSP00000497651.1, ENST00000649857.1
    Conserved Domains (3) summary
    smart00020
    Location:202431
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:154189
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:203431
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RNA

  1. NR_169739.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011542
  2. NR_169740.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011542

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    2360265..2426261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527978.2XP_011526280.1  transmembrane protease serine 9 isoform X1

    Related
    ENSP00000498031.1, ENST00000648592.1
    Conserved Domains (4) summary
    smart00020
    Location:236465
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:188223
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:8611087
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:66127
    SEA; SEA domain
  2. XM_011527980.1XP_011526282.1  transmembrane protease serine 9 isoform X2

    Conserved Domains (3) summary
    smart00020
    Location:457684
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:458684
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl21584
    Location:162
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. XM_011527982.3XP_011526284.1  transmembrane protease serine 9 isoform X3

    Conserved Domains (2) summary
    smart00020
    Location:329556
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:330556
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
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