Format

Send to:

Choose Destination

MAP3K9 mitogen-activated protein kinase kinase kinase 9 [ Homo sapiens (human) ]

Gene ID: 4293, updated on 10-Oct-2019

Summary

Official Symbol
MAP3K9provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 9provided by HGNC
Primary source
HGNC:HGNC:6861
See related
Ensembl:ENSG00000006432 MIM:600136
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MLK1; MEKK9; PRKE1
Expression
Broad expression in brain (RPKM 3.6), testis (RPKM 3.0) and 22 other tissues See more
Orthologs

Genomic context

See MAP3K9 in Genome Data Viewer
Location:
14q24.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (70722526..70809513, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (71189243..71275912, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 9 Neighboring gene long intergenic non-protein coding RNA 1269 Neighboring gene uncharacterized LOC100506411 Neighboring gene Sharpr-MPRA regulatory region 11364/13366 Neighboring gene transmembrane protein 183A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mitogen-activated protein kinase kinase kinase 9 (MAP3K9) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
JUN kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
JUN kinase kinase kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
MAP kinase kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
activation of JNKK activity IEA
Inferred from Electronic Annotation
more info
 
activation of JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase 9
Names
mixed lineage kinase 1 (tyr and ser/thr specificity)
NP_001271159.1
NP_001271160.1
NP_001271161.1
NP_149132.2
XP_005267740.1
XP_011535090.1
XP_011535094.1
XP_011535096.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284230.1NP_001271159.1  mitogen-activated protein kinase kinase kinase 9 isoform 2

    See identical proteins and their annotated locations for NP_001271159.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC004816, AY327900, BC033197, BC133706
    Consensus CDS
    CCDS61488.1
    UniProtKB/Swiss-Prot
    P80192
    UniProtKB/TrEMBL
    Q8NEB1
    Related
    ENSP00000451612.2, ENST00000554752.6
    Conserved Domains (2) summary
    cd12059
    Location:56113
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cd14145
    Location:137406
    STKc_MLK1; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1
  2. NM_001284231.1NP_001271160.1  mitogen-activated protein kinase kinase kinase 9 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC004816, AK302849, BC033197, BX648924, DB099391
    Consensus CDS
    CCDS73650.1
    UniProtKB/TrEMBL
    A0A087WW79, B4DZC4, Q8NEB1
    Related
    ENSP00000480011.1, ENST00000611979.4
    Conserved Domains (2) summary
    pfam13863
    Location:164249
    DUF4200; Domain of unknown function (DUF4200)
    cl21453
    Location:6143
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001284232.1NP_001271161.1  mitogen-activated protein kinase kinase kinase 9 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (4) is shorter and has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC004816, BC033197, BX648924, DB099391
    Consensus CDS
    CCDS61485.1
    UniProtKB/TrEMBL
    G3V347, Q8NEB1
    Related
    ENSP00000451038.1, ENST00000553414.5
    Conserved Domains (2) summary
    pfam13863
    Location:121206
    DUF4200; Domain of unknown function (DUF4200)
    cl21453
    Location:1100
    PKc_like; Protein Kinases, catalytic domain
  4. NM_033141.4NP_149132.2  mitogen-activated protein kinase kinase kinase 9 isoform 1

    See identical proteins and their annotated locations for NP_149132.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC004816, AY327900, BC033197, BX648924
    Consensus CDS
    CCDS32112.1
    UniProtKB/Swiss-Prot
    P80192
    UniProtKB/TrEMBL
    Q8NEB1
    Related
    ENSP00000451263.2, ENST00000555993.6
    Conserved Domains (3) summary
    smart00219
    Location:144403
    TyrKc; Tyrosine kinase, catalytic domain
    cd12059
    Location:56113
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cd14145
    Location:137406
    STKc_MLK1; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    70722526..70809513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267683.5XP_005267740.1  mitogen-activated protein kinase kinase kinase 9 isoform X2

    UniProtKB/TrEMBL
    J3KPI6
    Related
    ENSP00000370649.4, ENST00000381250.8
    Conserved Domains (3) summary
    smart00219
    Location:144403
    TyrKc; Tyrosine kinase, catalytic domain
    cd12059
    Location:56113
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cd14145
    Location:137406
    STKc_MLK1; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1
  2. XM_011536788.3XP_011535090.1  mitogen-activated protein kinase kinase kinase 9 isoform X1

    Conserved Domains (3) summary
    smart00219
    Location:144403
    TyrKc; Tyrosine kinase, catalytic domain
    cd12059
    Location:56113
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cd14145
    Location:137406
    STKc_MLK1; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1
  3. XM_011536792.1XP_011535094.1  mitogen-activated protein kinase kinase kinase 9 isoform X3

    See identical proteins and their annotated locations for XP_011535094.1

    Conserved Domains (2) summary
    pfam13863
    Location:121206
    DUF4200; Domain of unknown function (DUF4200)
    cl21453
    Location:1100
    PKc_like; Protein Kinases, catalytic domain
  4. XM_011536794.2XP_011535096.1  mitogen-activated protein kinase kinase kinase 9 isoform X4

    Conserved Domains (2) summary
    pfam13863
    Location:65150
    DUF4200; Domain of unknown function (DUF4200)
    cl21453
    Location:144
    PKc_like; Protein Kinases, catalytic domain
Support Center