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MAZ MYC associated zinc finger protein [ Homo sapiens (human) ]

Gene ID: 4150, updated on 21-Dec-2019

Summary

Official Symbol
MAZprovided by HGNC
Official Full Name
MYC associated zinc finger proteinprovided by HGNC
Primary source
HGNC:HGNC:6914
See related
Ensembl:ENSG00000103495 MIM:600999
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PUR1; ZF87; Pur-1; SAF-1; SAF-2; SAF-3; Zif87; ZNF801
Expression
Ubiquitous expression in bone marrow (RPKM 38.3), colon (RPKM 34.1) and 25 other tissues See more
Orthologs

Genomic context

See MAZ in Genome Data Viewer
Location:
16p11.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (29806081..29811171)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (29817417..29822504)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371167 Neighboring gene kinesin family member 22 Neighboring gene uncharacterized LOC107984837 Neighboring gene uncharacterized LOC112268170 Neighboring gene proline rich transmembrane protein 2 Neighboring gene PAXIP1 associated glutamate rich protein 1 Neighboring gene major vault protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
myc-associated zinc finger protein
Names
MAZI
purine-binding transcription factor
serum amyloid A activating factor 1
serum amyloid A activating factor 2
transcription factor Zif87
zinc finger protein 801
zinc-finger protein, 87 kilodaltons

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042539.3NP_001036004.1  myc-associated zinc finger protein isoform 2

    See identical proteins and their annotated locations for NP_001036004.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
    Source sequence(s)
    AC009133
    Consensus CDS
    CCDS42144.1
    UniProtKB/Swiss-Prot
    P56270
    Related
    ENSP00000219782.6, ENST00000219782.10
    Conserved Domains (2) summary
    COG5189
    Location:303360
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:281301
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001276275.2NP_001263204.1  myc-associated zinc finger protein isoform 3

    See identical proteins and their annotated locations for NP_001263204.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a portion of the 5' coding region, initiates translation at an alternate start codon, and lacks an exon in the 3' coding region, compared to variant 2. The encoded isoform (3) is shorter and has distinct N- and C-termini compared to isoform 2.
    Source sequence(s)
    AC009133
    Consensus CDS
    CCDS61902.1
    UniProtKB/Swiss-Prot
    P56270
    UniProtKB/TrEMBL
    Q59GP8
    Related
    ENSP00000443956.1, ENST00000545521.5
    Conserved Domains (3) summary
    COG5048
    Location:254302
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:258278
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:270295
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001276276.2NP_001263205.1  myc-associated zinc finger protein isoform 4

    See identical proteins and their annotated locations for NP_001263205.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks three exons in the coding region, one of which results in a frameshift, compared to variant 2. It encodes isoform 4 which has a distinct C-terminus and is shorter than isoform 2.
    Source sequence(s)
    AC009133
    Consensus CDS
    CCDS61903.1
    UniProtKB/Swiss-Prot
    P56270
    Related
    ENSP00000455726.1, ENST00000562337.5
    Conserved Domains (1) summary
    sd00017
    Location:6683
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_002383.4NP_002374.2  myc-associated zinc finger protein isoform 1

    See identical proteins and their annotated locations for NP_002374.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate exon in the 3' coding region which results in a frameshift, compared to variant 2. It encodes isoform 1 which has a distinct C-terminus and is shorter than isoform 2.
    Source sequence(s)
    AC009133
    Consensus CDS
    CCDS42143.1
    UniProtKB/Swiss-Prot
    P56270
    Related
    ENSP00000313362.6, ENST00000322945.11
    Conserved Domains (3) summary
    sd00017
    Location:281301
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:337357
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:293318
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_074080.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two internal exons, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC009133

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    29806081..29811171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721047.4XP_006721110.1  myc-associated zinc finger protein isoform X1

    See identical proteins and their annotated locations for XP_006721110.1

    Conserved Domains (2) summary
    COG5189
    Location:280337
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:258278
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. XR_002957805.1 RNA Sequence

  2. XR_002957806.1 RNA Sequence

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