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MARS methionyl-tRNA synthetase [ Homo sapiens (human) ]

Gene ID: 4141, updated on 4-Nov-2018

Summary

Official Symbol
MARSprovided by HGNC
Official Full Name
methionyl-tRNA synthetaseprovided by HGNC
Primary source
HGNC:HGNC:6898
See related
Ensembl:ENSG00000166986 MIM:156560; Vega:OTTHUMG00000169996
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRS; ILLD; CMT2U; ILFS2; METRS; MTRNS; SPG70
Summary
This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules. [provided by RefSeq, Jan 2011]
Expression
Ubiquitous expression in testis (RPKM 31.8), appendix (RPKM 28.7) and 25 other tissues See more
Orthologs

Genomic context

See MARS in Genome Data Viewer
Location:
12q13.3
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (57487953..57516655)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57881736..57910438)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene inhibin subunit beta E Neighboring gene GLI family zinc finger 1 Neighboring gene Rho GTPase activating protein 9 Neighboring gene microRNA 6758 Neighboring gene DNA damage inducible transcript 3 Neighboring gene microRNA 616 Neighboring gene methyl-CpG binding domain protein 6 Neighboring gene dynactin subunit 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of methionyl-tRNA synthetase (MARS) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Interaction of HIV-1 Gag with methionyl-tRNA synthetase (MARS) is identified in a series of six affinity purification/mass spectrometry screens PubMed
matrix gag HIV-1 MA is identified to have a physical interaction with methionyl-tRNA synthetase (MARS) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35667

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
methionine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
methionine-tRNA ligase activity TAS
Traceable Author Statement
more info
 
tRNA binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
aminoacyl-tRNA synthetase multienzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
membrane HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
methionine--tRNA ligase, cytoplasmic
Names
cytosolic methionyl-tRNA synthetase
NP_004981.2
XP_006719461.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034077.1 RefSeqGene

    Range
    5001..33703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004990.3NP_004981.2  methionine--tRNA ligase, cytoplasmic

    See identical proteins and their annotated locations for NP_004981.2

    Status: REVIEWED

    Source sequence(s)
    BC011849, D84224, DA489707
    Consensus CDS
    CCDS8942.1
    UniProtKB/Swiss-Prot
    P56192
    Related
    ENSP00000262027.5, OTTHUMP00000242693, ENST00000262027.9, OTTHUMT00000407014
    Conserved Domains (7) summary
    cd07957
    Location:642771
    Anticodon_Ia_Met; Anticodon-binding domain of methionyl tRNA synthetases
    cd00814
    Location:265633
    MetRS_core; catalytic core domain of methioninyl-tRNA synthetases
    cd10307
    Location:77179
    GST_C_MetRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Methionyl-tRNA synthetase from higher eukaryotes
    COG0625
    Location:47189
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    PRK12268
    Location:264819
    PRK12268; methionyl-tRNA synthetase; Reviewed
    cd00939
    Location:845889
    MetRS_RNA; MetRS_RNA binding domain. This short RNA-binding domain is found at the C-terminus of MetRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is repeated in Drosophila MetRS. This domain consists of a helix-turn-helix structure, which is ...
    cl00388
    Location:2768
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    57487953..57516655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719398.4XP_006719461.1  methionine--tRNA ligase, cytoplasmic isoform X1

    Conserved Domains (4) summary
    cd07957
    Location:408537
    Anticodon_Ia_Met; Anticodon-binding domain of methionyl tRNA synthetases
    cd00814
    Location:31399
    MetRS_core; catalytic core domain of methioninyl-tRNA synthetases
    PRK12268
    Location:30585
    PRK12268; methionyl-tRNA synthetase; Reviewed
    cd00939
    Location:611655
    MetRS_RNA; MetRS_RNA binding domain. This short RNA-binding domain is found at the C-terminus of MetRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is repeated in Drosophila MetRS. This domain consists of a helix-turn-helix structure, which is ...

RNA

  1. XR_002957327.1 RNA Sequence

    Related
    ENST00000545888.6
  2. XR_001748704.2 RNA Sequence

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