2CSX,1A8H,1RQG,1P7P


Conserved Protein Domain Family
Anticodon_Ia_Met

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cd07957: Anticodon_Ia_Met 
Click on image for an interactive view with Cn3D
Anticodon-binding domain of methionyl tRNA synthetases
This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Statistics
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PSSM-Id: 153411
View PSSM: cd07957
Aligned: 358 rows
Threshold Bit Score: 103.724
Threshold Setting Gi: 48477614
Created: 27-Apr-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
anticodontRNA binding
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:anticodon binding site
Evidence:
  • Structure:2CSX: Aquifex aeolicus methionyl tRNA synthetase binds the CAU-anticodon of tRNA(Met), contacts at 4 A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                #   ##  ##  ##  ##                                                      
2CSX_A       340 LNRINGELANEIGNLYSRVVNMAHKFLggevs----gardEEYAKIAQESIKNYENYMEKv----nFYKAIEEILKFTSY 411
gi 99038317  397 VNKDLADVLGNFVSRITKFCRSKFGEEvpdggt--wgeqeQTLIEELSTRIGAFERHMEAm----eVRKSAQELRAIWVA 470
gi 84703889  381 VNKDLADVLGNLVNRVTRFTASKFEGQvppgge--pgeaeQTLYREVDDRCAALTGALEAm----eFRKAFAALRGLWAA 454
gi 83858613  389 VNKDLADVLGNFVNRILKFGASRFEGVipeggt--pgeaeAWLETEVATRLANIASHYEAm----eFRKAAAETRALWAA 462
gi 197104673 422 VNADLADVLGNFVNRICKFAESRFEGQvpegge--pgeleTALEADVLMKLRELTGHLEDr----eFRKATTALRQLWVL 495
gi 114570377 389 INSDLANVLGNFVNRITKYTVSKFDGTlpsagt--pgeneAWMAAELDQRLPALVANMEAm----eFRKAAAEVRAIWAA 462
gi 110679753 394 VNKDLADVLGNFVSRITKFCAAKFGSEvpagga--ygsaeLELLTKLDESLTRYQDYMGAm----eVRKSAQELRAIWAS 467
gi 126725226 393 VNKDLANVLGNFISRITKFCRSKFSEAvpaapldaiaqerAGLWASLAPLIKEYETHMEAm----eVRKSANTLRAIWVV 468
gi 116057254 368 HNADLADVIGNLVHRVTNLCNKSCGGVvpd--------caTEDIFDVLAVRARSEAAMAKf----nIQAACEAAIEAVKA 435
gi 221505659 617 TNAELADTLGNLVHRATSLCVKFCEGKvpp--------vsLPAEGKAPFSIPDTVGEMERlvgqfgLREALEVAMNACRE 688
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
Feature 1            #     #                                            
2CSX_A       412 LNKYVDEKQPWALnkerkkeELQKVLYALVDGLFVLTHLLYPITPNKMKEALQML 466
gi 99038317  471 GNEYLQSAAPWSVfke-dpeRAAGQVRLGLNLIRLYAVLSAPFIPDASDRLFAAL 524
gi 84703889  455 GNEYLQVTAPWTAfkt-dpdAAAVSVRTALNLIMLIAEVSAPVIPETADKILGIF 508
gi 83858613  463 GNEYLTRAEPWVHfkt-dkdQAALGVRMGINLVRLCAIVAQPVIPQAAGKILAAL 516
gi 197104673 496 GNQYLTEAAPWTAikt-drdRAAVAVRYGLNLAALFAKVSEPFIPFAAEKVSLAL 549
gi 114570377 463 GNEYLTKAEPWVKyks-dvdAAAVGVRTGLNLVALFGILAQPFIPEAASKILDAL 516
gi 110679753 468 GNEYLQTVAPWSVfkt-dpeTAAMQTRLGLNLALLFGVLSSPFVPDASEKILKCL 521
gi 126725226 469 GNEYLQNTAPWTVnkt-dpeAAAAIVHVSLNLIRLFAVVSSPFIPHAAQQMMDDM 522
gi 116057254 436 TNKYLTDAAPWAVkgegaeeRKAVIIRSTIEAVYVSMHFLQPYIPTACEAIWELK 490
gi 221505659 689 ANKFLTDWAPWSLtd---stEKQRVVRGALEAVFVLGHLLEPFIPVTADHIFKKL 740

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