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MAP1B microtubule associated protein 1B [ Homo sapiens (human) ]

Gene ID: 4131, updated on 5-Sep-2021

Summary

Official Symbol
MAP1Bprovided by HGNC
Official Full Name
microtubule associated protein 1Bprovided by HGNC
Primary source
HGNC:HGNC:6836
See related
Ensembl:ENSG00000131711 MIM:157129
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAP5; PVNH9; FUTSCH; PPP1R102
Summary
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 49.2), adrenal (RPKM 7.7) and 10 other tissues See more
Orthologs
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Genomic context

See MAP1B in Genome Data Viewer
Location:
5q13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (72107475..72209565)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (71403302..71505392)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379027 Neighboring gene uncharacterized LOC107986382 Neighboring gene uncharacterized LOC105379028 Neighboring gene Sharpr-MPRA regulatory region 7919 Neighboring gene microRNA 4803 Neighboring gene Sharpr-MPRA regulatory region 4397 Neighboring gene mitochondrial ribosomal protein S27 Neighboring gene uncharacterized LOC107986422

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
GeneReviews: Not available
Periventricular nodular heterotopia 9
MedGen: C5394503 OMIM: 618918 GeneReviews: Not available
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HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif interacts with MAP1B; interaction predicted to be relevant to proteolysis PubMed
vif HIV-1 Vif downregulates the expression of microtubule-associated protein 1B (MAP1B) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38954, DKFZp686E1099, DKFZp686F1345

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables microtubule binding TAS
Traceable Author Statement
more info
PubMed 
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables structural molecule activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in axon extension TAS
Traceable Author Statement
more info
PubMed 
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to peptide hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in dendrite development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in developmental maturation IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of monopolar cell polarity IEA
Inferred from Electronic Annotation
more info
 
involved_in induction of synaptic plasticity by chemical substance IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule bundle formation IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrion transport along microtubule IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of intracellular transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of microtubule depolymerization IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron migration TAS
Traceable Author Statement
more info
PubMed 
involved_in peripheral nervous system axon regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of microtubule polymerization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to carbohydrate IEA
Inferred from Electronic Annotation
more info
 
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to inorganic substance IEA
Inferred from Electronic Annotation
more info
 
involved_in response to insecticide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to vitamin A IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in synapse assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in basal dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
located_in hippocampal mossy fiber ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of microtubule associated complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in photoreceptor outer segment IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
located_in somatodendritic compartment ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in varicosity IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
microtubule-associated protein 1B
Names
protein phosphatase 1, regulatory subunit 102

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324255.2NP_001311184.1  microtubule-associated protein 1B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK125194, AK307990, BC046114, BC073993, BN001085, HY119868
    UniProtKB/TrEMBL
    A2BDK6, Q86X89
    Conserved Domains (1) summary
    PRK14949
    Location:14051703
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
  2. NM_005909.5NP_005900.2  microtubule-associated protein 1B isoform 1

    See identical proteins and their annotated locations for NP_005900.2

    Status: VALIDATED

    Source sequence(s)
    AC012609, BC017240, BC046114, BN001084, CA429544
    Consensus CDS
    CCDS4012.1
    UniProtKB/Swiss-Prot
    P46821
    UniProtKB/TrEMBL
    Q6PJD3, Q86X89
    Related
    ENSP00000296755.7, ENST00000296755.12
    Conserved Domains (1) summary
    PRK14949
    Location:15311829
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    72107475..72209565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_032010.1: Suppressed sequence

    Description
    NM_032010.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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