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MAP1B microtubule associated protein 1B [ Homo sapiens (human) ]

Gene ID: 4131, updated on 4-Nov-2018

Summary

Official Symbol
MAP1Bprovided by HGNC
Official Full Name
microtubule associated protein 1Bprovided by HGNC
Primary source
HGNC:HGNC:6836
See related
Ensembl:ENSG00000131711 MIM:157129; Vega:OTTHUMG00000100952
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAP5; FUTSCH; PPP1R102
Summary
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 49.2), adrenal (RPKM 7.7) and 10 other tissues See more
Orthologs

Genomic context

See MAP1B in Genome Data Viewer
Location:
5q13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (72107268..72209570)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (71403118..71505397)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379027 Neighboring gene uncharacterized LOC107986382 Neighboring gene uncharacterized LOC105379028 Neighboring gene microRNA 4803 Neighboring gene mitochondrial ribosomal protein S27 Neighboring gene uncharacterized LOC107986422 Neighboring gene RNA, 7SL, cytoplasmic 153, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif interacts with MAP1B; interaction predicted to be relevant to proteolysis PubMed
vif HIV-1 Vif downregulates the expression of microtubule-associated protein 1B (MAP1B) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38954, DKFZp686E1099, DKFZp686F1345

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity NAS
Non-traceable Author Statement
more info
PubMed 
tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
axon extension TAS
Traceable Author Statement
more info
PubMed 
axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular process IDA
Inferred from Direct Assay
more info
PubMed 
dendrite development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment of monopolar cell polarity IEA
Inferred from Electronic Annotation
more info
 
microtubule bundle formation IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion transport along microtubule IEA
Inferred from Electronic Annotation
more info
 
negative regulation of intracellular transport IEA
Inferred from Electronic Annotation
more info
 
neuron migration TAS
Traceable Author Statement
more info
PubMed 
positive regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
basal dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
hippocampal mossy fiber ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule associated complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
photoreceptor outer segment IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
somatodendritic compartment ISS
Inferred from Sequence or Structural Similarity
more info
 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
microtubule-associated protein 1B
Names
protein phosphatase 1, regulatory subunit 102

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324255.1NP_001311184.1  microtubule-associated protein 1B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK125194, AK307990, BC046114, BC073993, BN001085, EB388369, HY119868
    UniProtKB/TrEMBL
    A2BDK6, Q86X89
    Conserved Domains (1) summary
    PRK14949
    Location:14051703
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
  2. NM_005909.4NP_005900.2  microtubule-associated protein 1B isoform 1

    See identical proteins and their annotated locations for NP_005900.2

    Status: VALIDATED

    Source sequence(s)
    AC012609, BC017240, BC046114, BN001084, CA429544, DA580501
    Consensus CDS
    CCDS4012.1
    UniProtKB/Swiss-Prot
    P46821
    UniProtKB/TrEMBL
    Q6PJD3, Q86X89
    Related
    ENSP00000296755.7, OTTHUMP00000126944, ENST00000296755.11, OTTHUMT00000218561
    Conserved Domains (1) summary
    PRK14949
    Location:15311829
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    72107268..72209570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_032010.1: Suppressed sequence

    Description
    NM_032010.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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