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Map1b microtubule-associated protein 1B [ Mus musculus (house mouse) ]

Gene ID: 17755, updated on 16-Apr-2024

Summary

Official Symbol
Map1bprovided by MGI
Official Full Name
microtubule-associated protein 1Bprovided by MGI
Primary source
MGI:MGI:1306778
See related
Ensembl:ENSMUSG00000052727 AllianceGenome:MGI:1306778
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LC1; MAP5; Mtap5; Mtap-5; Mtap1b; A230055D22
Summary
Predicted to enable actin binding activity; microtubule binding activity; and phospholipid binding activity. Acts upstream of or within several processes, including establishment of monopolar cell polarity; mitochondrion transport along microtubule; and neuron projection development. Located in several cellular components, including neuronal cell body; photoreceptor outer segment; and postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; intestine smooth muscle circular layer; nose; and trigeminal nerve. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human MAP1B (microtubule associated protein 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 66.4), CNS E18 (RPKM 61.4) and 10 other tissues See more
Orthologs
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Genomic context

See Map1b in Genome Data Viewer
Location:
13 D1; 13 52.9 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (99557972..99653110, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (99421464..99516602, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35456 Neighboring gene STARR-positive B cell enhancer mm9_chr13:100123104-100123405 Neighboring gene pentatricopeptide repeat domain 2 Neighboring gene mitochondrial ribosomal protein S27 Neighboring gene RIKEN cDNA 6430562O15 gene Neighboring gene STARR-seq mESC enhancer starr_35459 Neighboring gene predicted gene, 26559 Neighboring gene STARR-seq mESC enhancer starr_35465 Neighboring gene STARR-seq mESC enhancer starr_35466 Neighboring gene predicted gene, 24471

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC169657, MGC169658

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables cytoskeletal regulatory protein binding TAS
Traceable Author Statement
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within axonogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in dendrite development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of monopolar cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of intracellular transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within microtubule bundle formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule bundle formation ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within microtubule-based process TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within mitochondrion transport along microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of intracellular transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within odontoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of postsynapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in basal dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in hippocampal mossy fiber ISO
Inferred from Sequence Orthology
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
part_of microtubule associated complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of microtubule associated complex ISO
Inferred from Sequence Orthology
more info
 
part_of microtubule associated complex TAS
Traceable Author Statement
more info
PubMed 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor outer segment IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in somatodendritic compartment ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in varicosity ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
microtubule-associated protein 1B
Names
MAP-1B
MAP1(X)
MAP1.2
Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X))
microtubule-associated protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008634.2NP_032660.2  microtubule-associated protein 1B

    See identical proteins and their annotated locations for NP_032660.2

    Status: VALIDATED

    Source sequence(s)
    AC170188, AK148870, BC037105, BY003859
    Consensus CDS
    CCDS26723.1
    UniProtKB/Swiss-Prot
    E9QM11, P14873
    UniProtKB/TrEMBL
    B2RQQ5
    Related
    ENSMUSP00000068374.5, ENSMUST00000064762.6
    Conserved Domains (1) summary
    pfam05109
    Location:12651630
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    99557972..99653110 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517548.3XP_006517611.1  microtubule-associated protein 1B isoform X1

    UniProtKB/TrEMBL
    B2RQQ5
    Conserved Domains (1) summary
    pfam03154
    Location:12581701
    Atrophin-1; Atrophin-1 family