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MAN2A2 mannosidase alpha class 2A member 2 [ Homo sapiens (human) ]

Gene ID: 4122, updated on 6-May-2021

Summary

Official Symbol
MAN2A2provided by HGNC
Official Full Name
mannosidase alpha class 2A member 2provided by HGNC
Primary source
HGNC:HGNC:6825
See related
Ensembl:ENSG00000196547 MIM:600988
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MANA2X
Expression
Ubiquitous expression in bone marrow (RPKM 28.4), brain (RPKM 21.1) and 25 other tissues See more
Orthologs
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Genomic context

See MAN2A2 in Genome Data Viewer
Location:
15q26.1
Exon count:
27
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (90902377..90922585)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (91445612..91465815)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory regions 3826 and 8172 Neighboring gene furin, paired basic amino acid cleaving enzyme Neighboring gene FES proto-oncogene, tyrosine kinase Neighboring gene unc-45 myosin chaperone A Neighboring gene HD domain containing 3 Neighboring gene RCCD1 and UNC45A antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Specific alterations of the N-linked carbohydrates on HIV-1 gp120 and gp41 by glucosidases and mannosidase inhibitors can enhance mannose-binding lectin (MBL)-mediated neutralization of virus by strengthening the interaction of HIV-1 with MBL PubMed
env HIV-1 gp120 N-linked oligosaccharides are processed by manosidase I and II in the Golgi complex PubMed
Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed
Envelope transmembrane glycoprotein gp41 env Mannose-containing, N-linked oligosaccharide side-chains of HIV-1 gp41 are involved in the initial stage of infection by HIV-1; glycosylation inhibitors block virus-cell and cell-cell fusion and release of the virions PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, hydrolyzing N-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
 
enables mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mannose metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein deglycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alpha-mannosidase 2x
Names
MAN IIx
alpha-mannosidase IIx
mannosidase, alpha type II-X
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
manosidase, alpha-, type II, isozyme X
NP_001307906.1
NP_006113.2
XP_005254967.1
XP_011519867.1
XP_011519868.1
XP_016877673.1
XP_016877674.1
XP_024305688.1
XP_024305689.1
XP_024305690.1
XP_024305691.1
XP_024305692.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320977.2NP_001307906.1  alpha-mannosidase 2x isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC067986, AC068831
    Conserved Domains (1) summary
    PLN02701
    Location:1361174
    PLN02701; alpha-mannosidase
  2. NM_006122.4NP_006113.2  alpha-mannosidase 2x isoform 1

    See identical proteins and their annotated locations for NP_006113.2

    Status: VALIDATED

    Source sequence(s)
    AC067986, AC068831, AI912006, AK289863
    Consensus CDS
    CCDS32332.1
    UniProtKB/Swiss-Prot
    P49641
    Related
    ENSP00000452948.1, ENST00000559717.6
    Conserved Domains (1) summary
    PLN02701
    Location:1361149
    PLN02701; alpha-mannosidase

RNA

  1. NR_135502.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC067986, AC068831, AI912006, L28821
  2. NR_135503.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC067986, AC068831, AI912006, D55649
  3. NR_135504.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC067986, AC068831, AI912006, BC144111

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    90902377..90922585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254910.3XP_005254967.1  alpha-mannosidase 2x isoform X1

    See identical proteins and their annotated locations for XP_005254967.1

    Conserved Domains (1) summary
    PLN02701
    Location:1361174
    PLN02701; alpha-mannosidase
  2. XM_017022185.1XP_016877674.1  alpha-mannosidase 2x isoform X2

    UniProtKB/Swiss-Prot
    P49641
    Conserved Domains (1) summary
    PLN02701
    Location:1361149
    PLN02701; alpha-mannosidase
  3. XM_024449923.1XP_024305691.1  alpha-mannosidase 2x isoform X2

    Conserved Domains (1) summary
    PLN02701
    Location:1361149
    PLN02701; alpha-mannosidase
  4. XM_024449921.1XP_024305689.1  alpha-mannosidase 2x isoform X1

    Conserved Domains (1) summary
    PLN02701
    Location:1361174
    PLN02701; alpha-mannosidase
  5. XM_024449924.1XP_024305692.1  alpha-mannosidase 2x isoform X2

    Related
    ENSP00000453999.1, ENST00000560451.5
    Conserved Domains (1) summary
    PLN02701
    Location:1361149
    PLN02701; alpha-mannosidase
  6. XM_024449920.1XP_024305688.1  alpha-mannosidase 2x isoform X1

    Conserved Domains (1) summary
    PLN02701
    Location:1361174
    PLN02701; alpha-mannosidase
  7. XM_024449922.1XP_024305690.1  alpha-mannosidase 2x isoform X2

    Conserved Domains (1) summary
    PLN02701
    Location:1361149
    PLN02701; alpha-mannosidase
  8. XM_017022184.1XP_016877673.1  alpha-mannosidase 2x isoform X1

    Conserved Domains (1) summary
    PLN02701
    Location:1361174
    PLN02701; alpha-mannosidase
  9. XM_011521565.2XP_011519867.1  alpha-mannosidase 2x isoform X3

    Conserved Domains (2) summary
    pfam07748
    Location:340749
    Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
    cl08536
    Location:105167
    Alpha-mann_mid; Alpha mannosidase, middle domain
  10. XM_011521566.2XP_011519868.1  alpha-mannosidase 2x isoform X4

    Related
    ENSP00000453140.1, ENST00000557865.5
    Conserved Domains (2) summary
    pfam07748
    Location:340724
    Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
    cl08536
    Location:105167
    Alpha-mann_mid; Alpha mannosidase, middle domain

RNA

  1. XR_002957637.1 RNA Sequence

  2. XR_002957636.1 RNA Sequence

  3. XR_001751281.2 RNA Sequence

    Related
    ENST00000558161.5
  4. XR_931829.2 RNA Sequence

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