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Man2a2 mannosidase 2, alpha 2 [ Mus musculus (house mouse) ]

Gene ID: 140481, updated on 18-Sep-2024

Summary

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Official Symbol
Man2a2provided by MGI
Official Full Name
mannosidase 2, alpha 2provided by MGI
Primary source
MGI:MGI:2150656
See related
Ensembl:ENSMUSG00000038886 AllianceGenome:MGI:2150656
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MX; Man IIx; 1700052O22Rik; 4931438M07Rik
Summary
Enables hydrolase activity, hydrolyzing N-glycosyl compounds and mannosidase activity. Predicted to be involved in N-glycan processing and protein deglycosylation. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane. Is expressed in olfactory epithelium; retina outer nuclear layer; skeletal muscle; and vomeronasal organ. Orthologous to human MAN2A2 (mannosidase alpha class 2A member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 32.8), mammary gland adult (RPKM 28.0) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 D2; 7 45.65 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79998843..80021222, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80349095..80371483, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene unc-45 myosin chaperone A Neighboring gene STARR-positive B cell enhancer ABC_E2828 Neighboring gene STARR-positive B cell enhancer ABC_E6566 Neighboring gene HD domain containing 3 Neighboring gene high mobility group box 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87520664-87520847 Neighboring gene feline sarcoma oncogene Neighboring gene furin, paired basic amino acid cleaving enzyme Neighboring gene predicted gene 44851

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In vivo role of alpha-mannosidase IIx: ineffective spermatogenesis resulting from targeted disruption of the Man2a2 in the mouse. Fukuda MN, et al. Biochim Biophys Acta, 2002 Dec 19. PMID 12417422
  2. N-Glycan structure analysis using lectins and an alpha-mannosidase activity assay. Akama TO, et al. Methods Enzymol, 2006. PMID 17113875
  3. Germ cell survival through carbohydrate-mediated interaction with Sertoli cells. Akama TO, et al. Science, 2002 Jan 4. PMID 11778047
  4. Stage-specific expression of a mouse homologue of the porcine 135kDa alpha-D-mannosidase (MAN2B2) in type A spermatogonia. Hiramoto S, et al. Biochem Biophys Res Commun, 1997 Dec 18. PMID 9425289
  5. Essential and mutually compensatory roles of {alpha}-mannosidase II and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice. Akama TO, et al. Proc Natl Acad Sci U S A, 2006 Jun 13. PMID 16754854, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MX was produced by transfecting mammalian cells with expression vectors and the substrate specificity of MX was determined.
    Title: N-Glycan structure analysis using lectins and an alpha-mannosidase activity assay.
  2. Data show that either alpha-Mannosidase II or IIX can biochemically compensate for the deficiency of the other in vivo, and either of two is required for late embryonic and early postnatal development.
    Title: Essential and mutually compensatory roles of {alpha}-mannosidase II and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice.
  3. Man2a2 null spermatogenic cells fail to adhere to Sertoli cells and are prematurely released from the testis to epididymis
    Title: Germ cell survival through carbohydrate-mediated interaction with Sertoli cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing N-glycosyl compounds IDA
Inferred from Direct Assay
more info
 PubMed 
enables mannosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mannose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-mannosidase 2x
Names
alpha-mannosidase IIx
mannosidase, alpha, class 2A, member 2
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
NP_766491.2
XP_006540662.1
XP_036008560.1
XP_036008561.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172903.4 → NP_766491.2  alpha-mannosidase 2x

    See identical proteins and their annotated locations for NP_766491.2

    Status: VALIDATED

    Source sequence(s)
    AC136740, AK029913, BC055006, CJ105476
    Consensus CDS
    CCDS57556.1
    UniProtKB/Swiss-Prot
    Q3UVK1, Q8BRK9
    UniProtKB/TrEMBL
    Q197W7
    Related
    ENSMUSP00000095949.4, ENSMUST00000098346.5
    Conserved Domains (1) summary
    PLN02701
    Location:140 → 1151
    PLN02701; alpha-mannosidase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    79998843..80021222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152667.1 → XP_036008560.1  alpha-mannosidase 2x isoform X1

    UniProtKB/Swiss-Prot
    Q3UVK1, Q8BRK9
    UniProtKB/TrEMBL
    Q197W7
    Conserved Domains (1) summary
    PLN02701
    Location:140 → 1151
    PLN02701; alpha-mannosidase

  2. XM_006540599.4 → XP_006540662.1  alpha-mannosidase 2x isoform X1

    See identical proteins and their annotated locations for XP_006540662.1

    UniProtKB/Swiss-Prot
    Q3UVK1, Q8BRK9
    UniProtKB/TrEMBL
    Q197W7
    Conserved Domains (1) summary
    PLN02701
    Location:140 → 1151
    PLN02701; alpha-mannosidase

  3. XM_036152668.1 → XP_036008561.1  alpha-mannosidase 2x isoform X2

    UniProtKB/TrEMBL
    Q7TPQ0
    Conserved Domains (1) summary
    PLN02701
    Location:4 → 527
    PLN02701; alpha-mannosidase

RNA

  1. XR_003946387.2 RNA Sequence

  2. XR_001785475.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BRK9.2 GenPept UniProtKB/Swiss-Prot:Q8BRK9

Gene LinkOut

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