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MAGOH mago homolog, exon junction complex subunit [ Homo sapiens (human) ]

Gene ID: 4116, updated on 8-Jul-2021

Summary

Official Symbol
MAGOHprovided by HGNC
Official Full Name
mago homolog, exon junction complex subunitprovided by HGNC
Primary source
HGNC:HGNC:6815
See related
Ensembl:ENSG00000162385 MIM:602603
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAGOH1; MAGOHA
Summary
Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 28.8), colon (RPKM 24.3) and 25 other tissues See more
Orthologs
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Genomic context

See MAGOH in Genome Data Viewer
Location:
1p32.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (53226900..53238518, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (53692572..53704190, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378724 Neighboring gene carnitine palmitoyltransferase 2 pseudogene 1 Neighboring gene carnitine palmitoyltransferase 2 Neighboring gene CXXC motif containing zinc binding protein Neighboring gene MAGOH divergent transcript Neighboring gene uncharacterized LOC105378728 Neighboring gene LDL receptor related protein 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
An atlas of genetic influences on human blood metabolites.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of exon-exon junction complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of exon-exon junction complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein mago nashi homolog
Names
mago homolog, exon junction complex core component
mago-nashi homolog, proliferation-associated

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002370.4NP_002361.1  protein mago nashi homolog

    See identical proteins and their annotated locations for NP_002361.1

    Status: REVIEWED

    Source sequence(s)
    AF035940, AF067173
    Consensus CDS
    CCDS577.1
    UniProtKB/Swiss-Prot
    P61326
    Related
    ENSP00000360525.3, ENST00000371470.8
    Conserved Domains (1) summary
    cd11295
    Location:4146
    Mago_nashi; Mago nashi proteins, integral members of the exon junction complex

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    53226900..53238518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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