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Magoh mago homolog, exon junction complex core component [ Mus musculus (house mouse) ]

Gene ID: 17149, updated on 12-May-2024

Summary

Official Symbol
Magohprovided by MGI
Official Full Name
mago homolog, exon junction complex core componentprovided by MGI
Primary source
MGI:MGI:1330312
See related
Ensembl:ENSMUSG00000028609 AllianceGenome:MGI:1330312
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mos2; Mago-m
Summary
Predicted to enable RNA binding activity. Predicted to be involved in RNA splicing; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and regulation of alternative mRNA splicing, via spliceosome. Predicted to act upstream of or within mRNA processing; mRNA transport; and regulation of translation. Predicted to be located in nucleus. Predicted to be part of catalytic step 2 spliceosome and exon-exon junction complex. Is expressed in intestine; liver; spleen; and testis. Orthologous to human MAGOH (mago homolog, exon junction complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 75.7), placenta adult (RPKM 62.8) and 27 other tissues See more
Orthologs
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Genomic context

See Magoh in Genome Data Viewer
Location:
4 C7; 4 50.18 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (107736952..107744621)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (107879755..107887424)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor-related protein 8, apolipoprotein e receptor, opposite strand 3 Neighboring gene STARR-positive B cell enhancer ABC_E7978 Neighboring gene low density lipoprotein receptor-related protein 8, apolipoprotein e receptor, opposite strand 2 Neighboring gene low density lipoprotein receptor-related protein 8, apolipoprotein e receptor Neighboring gene STARR-positive B cell enhancer ABC_E4643 Neighboring gene STARR-positive B cell enhancer ABC_E1649 Neighboring gene CXXC motif containing zinc binding protein Neighboring gene carnitine palmitoyltransferase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol NAS
Non-traceable Author Statement
more info
PubMed 
part_of exon-exon junction complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of exon-exon junction complex ISO
Inferred from Sequence Orthology
more info
 
part_of exon-exon junction subcomplex mago-y14 ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein mago nashi homolog
Names
mago-nashi homolog, proliferation-associated

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282737.1NP_001269666.1  protein mago nashi homolog

    See identical proteins and their annotated locations for NP_001269666.1

    Status: VALIDATED

    Source sequence(s)
    AK011512, BY134232
    Consensus CDS
    CCDS18441.1
    UniProtKB/Swiss-Prot
    A2A8E0, P61327
    Related
    ENSMUSP00000030348.6, ENSMUST00000030348.6
    Conserved Domains (1) summary
    cd11295
    Location:4146
    Mago_nashi; Mago nashi proteins, integral members of the exon junction complex

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    107736952..107744621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)