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CZIB CXXC motif containing zinc binding protein [ Homo sapiens (human) ]

Gene ID: 54987, updated on 1-Jun-2020

Summary

Official Symbol
CZIBprovided by HGNC
Official Full Name
CXXC motif containing zinc binding proteinprovided by HGNC
Primary source
HGNC:HGNC:26059
See related
Ensembl:ENSG00000162384
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C1orf123
Expression
Ubiquitous expression in fat (RPKM 26.2), endometrium (RPKM 21.0) and 25 other tissues See more
Orthologs

Genomic context

See CZIB in Genome Data Viewer
Location:
1p32.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (53214099..53220639, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (53679771..53686289, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 1 member 7 Neighboring gene VISTA enhancer hs2585 Neighboring gene uncharacterized LOC105378724 Neighboring gene carnitine palmitoyltransferase 2 pseudogene 1 Neighboring gene carnitine palmitoyltransferase 2 Neighboring gene uncharacterized LOC100507564 Neighboring gene mago homolog, exon junction complex subunit Neighboring gene LDL receptor related protein 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: MAGOH

Homology

Clone Names

  • FLJ20580

Gene Ontology Provided by GOA

Function Evidence Code Pubs
zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 

General protein information

Preferred Names
CXXC motif containing zinc binding protein
Names
UPF0587 protein C1orf123

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304759.1NP_001291688.1  CXXC motif containing zinc binding protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK000587, BC010908, BI603716, DA305789
    UniProtKB/Swiss-Prot
    Q9NWV4
    Conserved Domains (1) summary
    pfam05907
    Location:6138
    DUF866; Eukaryotic protein of unknown function (DUF866)
  2. NM_001304760.1NP_001291689.1  CXXC motif containing zinc binding protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 5' end compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK000587, BC010908, BE889129, DA305789
    UniProtKB/Swiss-Prot
    Q9NWV4
    Conserved Domains (1) summary
    pfam05907
    Location:3110
    DUF866; Eukaryotic protein of unknown function (DUF866)
  3. NM_017887.3NP_060357.1  CXXC motif containing zinc binding protein isoform 1

    See identical proteins and their annotated locations for NP_060357.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK000587, BC010908, DA305789
    Consensus CDS
    CCDS576.1
    UniProtKB/Swiss-Prot
    Q9NWV4
    Related
    ENSP00000294360.4, ENST00000294360.5
    Conserved Domains (1) summary
    pfam05907
    Location:6157
    DUF866; Eukaryotic protein of unknown function (DUF866)

RNA

  1. NR_130897.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks the 3' and middle exons and retains intronic sequence at its 3' end compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AL606760, DA305789, DA394291

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    53214099..53220639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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