fbxw5 F-box and WD repeat domain containing 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fbxw5provided by ZNC
Official Full Name: F-box and WD repeat domain containing 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2571
See related: Ensembl:ENSDARG00000099139 AllianceGenome:ZFIN:ZDB-GENE-040426-2571
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:63874; wu:fd14c04
Summary: Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and regulation of centrosome duplication. Predicted to be located in cytoplasm. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex and SCF ubiquitin ligase complex. Orthologous to human FBXW5 (F-box and WD repeat domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 5

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (54457881..54481692, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (53811288..53835099, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fa01c11.s1 (e-PCR)
- UniSTS:189482

ha3079 (e-PCR)
- UniSTS:515639

fd14c04.x1 (e-PCR)
- UniSTS:204163

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of centrosome duplication	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of Cul4-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of SCF ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of SCF ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: F-box/WD repeat-containing protein 5

Names: F-box and WD-40 domain protein 5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213319.2 → NP_998484.1 F-box/WD repeat-containing protein 5

See identical proteins and their annotated locations for NP_998484.1

Status: VALIDATED

Source sequence(s)

BX294186, CU468929

UniProtKB/TrEMBL

A0A8M1PPM5, Q6PFV0

Related

ENSDARP00000141973.1, ENSDART00000165719.2

Conserved Domains (5) summary

smart00320
Location:83 → 118

WD40; WD40 repeats

COG2319
Location:467 → 560

WD40; WD40 repeat [General function prediction only]

pfam12937
Location:7 → 50

F-box-like; F-box-like

sd00039
Location:494 → 530

7WD40; WD40 repeat [structural motif]

cl02567
Location:477 → 560

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...