Format

Send to:

Choose Destination

FBXW5 F-box and WD repeat domain containing 5 [ Homo sapiens (human) ]

Gene ID: 54461, updated on 8-Jul-2021

Summary

Official Symbol
FBXW5provided by HGNC
Official Full Name
F-box and WD repeat domain containing 5provided by HGNC
Primary source
HGNC:HGNC:13613
See related
Ensembl:ENSG00000159069 MIM:609072
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fbw5
Summary
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 77.8), colon (RPKM 28.1) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See FBXW5 in Genome Data Viewer
Location:
9q34.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (136940435..136944774, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139834887..139839190, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376326 Neighboring gene TNF receptor associated factor 2 Neighboring gene microRNA 4479 Neighboring gene complement C8 gamma chain Neighboring gene lipocalin 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC20962, DKFZp434B205

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
F-box/WD repeat-containing protein 5
Names
F-box and WD-40 domain-containing protein 5
WD repeat-containing F-box protein FBW5

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018998.4NP_061871.1  F-box/WD repeat-containing protein 5

    See identical proteins and their annotated locations for NP_061871.1

    Status: REVIEWED

    Source sequence(s)
    BC014130, CF132404, DB460097
    Consensus CDS
    CCDS7014.1
    UniProtKB/Swiss-Prot
    Q969U6
    UniProtKB/TrEMBL
    A0A024R8H7
    Related
    ENSP00000313034.3, ENST00000325285.8
    Conserved Domains (5) summary
    smart00320
    Location:85120
    WD40; WD40 repeats
    COG2319
    Location:395538
    WD40; WD40 repeat [General function prediction only]
    pfam12937
    Location:952
    F-box-like; F-box-like
    sd00039
    Location:419461
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:447538
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    136940435..136944774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518789.1XP_011517091.1  F-box/WD repeat-containing protein 5 isoform X2

    Conserved Domains (5) summary
    smart00320
    Location:85117
    WD40; WD40 repeats
    COG2319
    Location:387530
    WD40; WD40 repeat [General function prediction only]
    pfam12937
    Location:952
    F-box-like; F-box-like
    sd00039
    Location:411453
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:439530
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_005266089.2XP_005266146.2  F-box/WD repeat-containing protein 5 isoform X1

    Conserved Domains (5) summary
    smart00320
    Location:85117
    WD40; WD40 repeats
    COG2319
    Location:405548
    WD40; WD40 repeat [General function prediction only]
    pfam12937
    Location:952
    F-box-like; F-box-like
    sd00039
    Location:429471
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:457548
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_017014812.2XP_016870301.1  F-box/WD repeat-containing protein 5 isoform X3

    Related
    ENST00000459905.5

RNA

  1. XR_929811.1 RNA Sequence

  2. XR_001746323.1 RNA Sequence

  3. XR_002956794.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178225.1: Suppressed sequence

    Description
    NM_178225.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_178226.1: Suppressed sequence

    Description
    NM_178226.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Support Center