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YY2 YY2 transcription factor [ Homo sapiens (human) ]

Gene ID: 404281, updated on 5-Jan-2022

Summary

Official Symbol
YY2provided by HGNC
Official Full Name
YY2 transcription factorprovided by HGNC
Primary source
HGNC:HGNC:31684
See related
Ensembl:ENSG00000230797 MIM:300570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF631
Summary
The protein encoded by this gene is a transcription factor that includes several Kruppel-like zinc fingers in its C-terminal region. It possesses both activation and repression domains, and it can therefore have both positive and negative effects on the transcription of target genes. This gene has an intronless coding region, and it appears to have arisen by retrotransposition of the related YY1 transcription factor gene, which is located on chromosome 14. [provided by RefSeq, May 2010]
Orthologs
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Genomic context

See YY2 in Genome Data Viewer
Location:
Xp22.12
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (21855987..21858740)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (21874105..21876858)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene kelch like family member 34 Neighboring gene small muscle protein X-linked Neighboring gene membrane bound transcription factor peptidase, site 2 Neighboring gene CYTH1 pseudogene 1 Neighboring gene spermine synthase

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of PcG protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription factor YY2
Names
transcription factor yin yang 2
yin and yang 2
zinc finger protein 631

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021268.1 RefSeqGene

    Range
    5001..7754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206923.4NP_996806.2  transcription factor YY2

    See identical proteins and their annotated locations for NP_996806.2

    Status: REVIEWED

    Source sequence(s)
    AK091850, BC137215, DB029513, DB459498, U73479
    Consensus CDS
    CCDS14202.1
    UniProtKB/Swiss-Prot
    O15391
    Related
    ENSP00000389381.2, ENST00000429584.3
    Conserved Domains (4) summary
    COG5048
    Location:309372
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:285305
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:298323
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:255334
    zf-C2H2_8; C2H2-type zinc ribbon

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    21855987..21858740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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