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LPO lactoperoxidase [ Homo sapiens (human) ]

Gene ID: 4025, updated on 3-May-2020

Summary

Official Symbol
LPOprovided by HGNC
Official Full Name
lactoperoxidaseprovided by HGNC
Primary source
HGNC:HGNC:6678
See related
Ensembl:ENSG00000167419 MIM:150205
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPO
Summary
This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Expression
Restricted expression toward salivary gland (RPKM 211.8) See more
Orthologs

Genomic context

See LPO in Genome Data Viewer
Location:
17q22
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (58238426..58268518)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (56315787..56345879)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene eosinophil peroxidase Neighboring gene MKS transition zone complex subunit 1 Neighboring gene uncharacterized LOC105371841 Neighboring gene enhancer region in introns 7-9 of MPO Neighboring gene MPO proximal enhancer and promoter region Neighboring gene myeloperoxidase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
reverse transcriptase gag-pol Milk protein lactoperoxidase inhibits HIV-1 RT activity in vitro PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129990, MGC129991

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heme binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiocyanate peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiocyanate peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell redox homeostasis TAS
Traceable Author Statement
more info
 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
detection of chemical stimulus involved in sensory perception of bitter taste IDA
Inferred from Direct Assay
more info
PubMed 
hydrogen peroxide catabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
response to oxidative stress NAS
Non-traceable Author Statement
more info
PubMed 
thiocyanate metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
lactoperoxidase
Names
salivary peroxidase
NP_001153574.1
NP_006142.1
XP_011523110.1
XP_011523112.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160102.1NP_001153574.1  lactoperoxidase isoform 3 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the 5' coding region, compared to variant 1. The resulting isoform (3) lacks an internal segment near the N-terminus, compared to isoform 1. This isoform is thought to be secreted but the sites of proteolytic processing have not been determined.
    Source sequence(s)
    DB230339, EF579964, M58151, U39573
    Consensus CDS
    CCDS54149.1
    UniProtKB/Swiss-Prot
    P22079
    Related
    ENSP00000400245.2, ENST00000421678.6
    Conserved Domains (2) summary
    cd09824
    Location:200611
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases
    pfam03098
    Location:55591
    An_peroxidase; Animal haem peroxidase
  2. NM_006151.3NP_006142.1  lactoperoxidase isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_006142.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest and predominant transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC107166, M58151, U39573
    Consensus CDS
    CCDS32689.1
    UniProtKB/Swiss-Prot
    P22079
    Related
    ENSP00000262290.4, ENST00000262290.9
    Conserved Domains (2) summary
    cd09824
    Location:283694
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases
    pfam03098
    Location:138674
    An_peroxidase; Animal haem peroxidase

RNA

  1. NR_027647.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region that causes a frameshift, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK303903, BC107166, DB230339, M58151, U39573
    Related
    ENST00000543544.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    58238426..58268518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524808.2XP_011523110.1  lactoperoxidase isoform X1

    Conserved Domains (2) summary
    cl14561
    Location:283556
    An_peroxidase_like; Animal heme peroxidases and related proteins
    pfam03098
    Location:138536
    An_peroxidase; Animal haem peroxidase
  2. XM_011524810.2XP_011523112.1  lactoperoxidase isoform X2

    Conserved Domains (2) summary
    cd09824
    Location:30441
    myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases
    pfam03098
    Location:9421
    An_peroxidase; Animal haem peroxidase
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