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ARL2 ADP ribosylation factor like GTPase 2 [ Homo sapiens (human) ]

Gene ID: 402, updated on 18-Aug-2020

Summary

Official Symbol
ARL2provided by HGNC
Official Full Name
ADP ribosylation factor like GTPase 2provided by HGNC
Primary source
HGNC:HGNC:693
See related
Ensembl:ENSG00000213465 MIM:601175
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARFL2
Summary
This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 49.3), fat (RPKM 49.1) and 25 other tissues See more
Orthologs

Genomic context

See ARL2 in Genome Data Viewer
Location:
11q13.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (65014160..65022184)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64781585..64789657)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene basic leucine zipper ATF-like transcription factor 2 Neighboring gene CRISPRi-validated cis-regulatory element chr11.3163 Neighboring gene ARL2-SNX15 readthrough (NMD candidate) Neighboring gene microRNA 6879 Neighboring gene Sharpr-MPRA regulatory region 4003 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 18 Neighboring gene sorting nexin 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough ARL2-SNX15

Readthrough gene: ARL2-SNX15, Included gene: SNX15

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IEA
Inferred from Electronic Annotation
more info
 
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
GTPase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
bicellular tight junction assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
maintenance of protein location in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell-substrate adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of microtubule polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of microtubule polymerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of insulin secretion TAS
Traceable Author Statement
more info
 
regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
tubulin complex assembly TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
NOT cilium IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
 
lateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ADP-ribosylation factor-like protein 2
Names
ADP-ribosylation factor-like 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199745.2NP_001186674.1  ADP-ribosylation factor-like protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001186674.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AI631767, BC002530, BG706294, CN338497
    Consensus CDS
    CCDS55770.1
    UniProtKB/Swiss-Prot
    P36404
    Related
    ENSP00000432971.1, ENST00000533729.1
    Conserved Domains (2) summary
    cd04154
    Location:3148
    Arl2; Arf-like 2 (Arl2) GTPase
    COG1100
    Location:13120
    Gem1; GTPase SAR1 family domain [General function prediction only]
  2. NM_001667.4NP_001658.2  ADP-ribosylation factor-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001658.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI631767, BC002530, BG706294
    Consensus CDS
    CCDS8088.1
    UniProtKB/Swiss-Prot
    P36404
    UniProtKB/TrEMBL
    Q53YD8
    Related
    ENSP00000246747.4, ENST00000246747.9
    Conserved Domains (1) summary
    cd04154
    Location:3175
    Arl2; Arf-like 2 (Arl2) GTPase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    65014160..65022184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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