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SNX15 sorting nexin 15 [ Homo sapiens (human) ]

Gene ID: 29907, updated on 9-Jun-2020

Summary

Official Symbol
SNX15provided by HGNC
Official Full Name
sorting nexin 15provided by HGNC
Primary source
HGNC:HGNC:14978
See related
Ensembl:ENSG00000110025 MIM:605964
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSAF001435
Summary
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in fat (RPKM 9.4), kidney (RPKM 8.6) and 25 other tissues See more
Orthologs

Genomic context

See SNX15 in Genome Data Viewer
Location:
11q13.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (65027439..65040572)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64794880..64808044)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ARL2-SNX15 readthrough (NMD candidate) Neighboring gene ADP ribosylation factor like GTPase 2 Neighboring gene microRNA 6879 Neighboring gene Sharpr-MPRA regulatory region 4003 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 18 Neighboring gene SAC3 domain containing 1 Neighboring gene N-acetylated alpha-linked acidic dipeptidase like 1 Neighboring gene cell division cycle associated 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough ARL2-SNX15

Readthrough gene: ARL2-SNX15, Included gene: ARL2

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
intracellular protein transport NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol NAS
Non-traceable Author Statement
more info
PubMed 
early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane NAS
Non-traceable Author Statement
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
sorting nexin-15
Names
clone iota unknown protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029947.1 RefSeqGene

    Range
    5001..18165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_013306.5NP_037438.2  sorting nexin-15 isoform A

    See identical proteins and their annotated locations for NP_037438.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A, also known as SNX15) represents the longer transcript and encodes the longer isoform (A).
    Source sequence(s)
    AP000436, AP003068
    Consensus CDS
    CCDS8089.1
    UniProtKB/Swiss-Prot
    Q9NRS6
    UniProtKB/TrEMBL
    E5KQS5
    Related
    ENSP00000366452.3, ENST00000377244.8
    Conserved Domains (2) summary
    cd02677
    Location:267341
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cl02563
    Location:9126
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  2. NM_147777.4NP_680086.2  sorting nexin-15 isoform B

    See identical proteins and their annotated locations for NP_680086.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B, also known as SNX15A) lacks an alternate in-frame exon in the 3' coding region, compared to variant A, resulting in an isoform (B) that is shorter than isoform A.
    Source sequence(s)
    AP000436, AP003068
    Consensus CDS
    CCDS8090.1
    UniProtKB/Swiss-Prot
    Q9NRS6
    Related
    ENSP00000316410.5, ENST00000352068.5
    Conserved Domains (2) summary
    cl00299
    Location:182255
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    cl02563
    Location:9126
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    65027439..65040572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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