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LRRC74B leucine rich repeat containing 74B [ Homo sapiens (human) ]

Gene ID: 400891, updated on 23-Nov-2021

Summary

Official Symbol
LRRC74Bprovided by HGNC
Official Full Name
leucine rich repeat containing 74Bprovided by HGNC
Primary source
HGNC:HGNC:34301
See related
Ensembl:ENSG00000187905
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 1.1), lung (RPKM 0.6) and 1 other tissue See more
Orthologs
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Genomic context

See LRRC74B in Genome Data Viewer
Location:
22q11.21
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (21045946..21064168)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (21400235..21418457)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene microRNA 649 Neighboring gene purinergic receptor P2X 6 pseudogene Neighboring gene tubulin alpha 3g pseudogene Neighboring gene uncharacterized LOC112268300

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

General protein information

Preferred Names
leucine-rich repeat-containing protein 74B
Names
leucine-rich repeat-containing protein LOC400891

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291006.2NP_001277935.1  leucine-rich repeat-containing protein 74B

    See identical proteins and their annotated locations for NP_001277935.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the protein.
    Source sequence(s)
    AC002472
    Consensus CDS
    CCDS77654.1
    UniProtKB/Swiss-Prot
    Q6ZQY2
    Related
    ENSP00000394078.2, ENST00000442047.2
    Conserved Domains (2) summary
    cd00116
    Location:57357
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:109136
    LRR_RI; leucine-rich repeat [structural motif]

RNA

  1. NR_027006.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains multiple differences in the internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most [supported/expected] translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC002472, AK128646, BC028231, BC036220
  2. NR_110991.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains multiple differences in the internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most [supported/expected] translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC002472
    Related
    ENST00000497328.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    21045946..21064168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530173.2XP_011528475.1  leucine-rich repeat-containing protein 74B isoform X1

    Conserved Domains (2) summary
    cd00116
    Location:57331
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:109136
    LRR_RI; leucine-rich repeat [structural motif]
  2. XM_011530175.1XP_011528477.1  leucine-rich repeat-containing protein 74B isoform X3

    See identical proteins and their annotated locations for XP_011528477.1

    Conserved Domains (2) summary
    cd00116
    Location:58205
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:5480
    LRR_RI; leucine-rich repeat [structural motif]
  3. XM_011530177.1XP_011528479.1  leucine-rich repeat-containing protein 74B isoform X3

    See identical proteins and their annotated locations for XP_011528479.1

    Conserved Domains (2) summary
    cd00116
    Location:58205
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:5480
    LRR_RI; leucine-rich repeat [structural motif]
  4. XM_011530176.2XP_011528478.1  leucine-rich repeat-containing protein 74B isoform X3

    See identical proteins and their annotated locations for XP_011528478.1

    Conserved Domains (2) summary
    cd00116
    Location:58205
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:5480
    LRR_RI; leucine-rich repeat [structural motif]
  5. XM_011530174.1XP_011528476.1  leucine-rich repeat-containing protein 74B isoform X3

    See identical proteins and their annotated locations for XP_011528476.1

    Conserved Domains (2) summary
    cd00116
    Location:58205
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:5480
    LRR_RI; leucine-rich repeat [structural motif]
  6. XM_017028797.1XP_016884286.1  leucine-rich repeat-containing protein 74B isoform X2

RNA

  1. XR_937850.2 RNA Sequence

  2. XR_937849.1 RNA Sequence

  3. XR_937851.1 RNA Sequence

  4. XR_937857.1 RNA Sequence

  5. XR_937858.1 RNA Sequence

  6. XR_937847.1 RNA Sequence

  7. XR_937859.1 RNA Sequence

  8. XR_937862.1 RNA Sequence

  9. XR_937856.1 RNA Sequence

  10. XR_937861.1 RNA Sequence

  11. XR_937860.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013675.1: Suppressed sequence

    Description
    NM_001013675.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
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