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LRRC74B leucine rich repeat containing 74B [ Homo sapiens (human) ]

Gene ID: 400891, updated on 17-Sep-2024

Summary

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Official Symbol
LRRC74Bprovided by HGNC
Official Full Name
leucine rich repeat containing 74Bprovided by HGNC
Primary source
HGNC:HGNC:34301
See related
Ensembl:ENSG00000187905 AllianceGenome:HGNC:34301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 1.1), lung (RPKM 0.6) and 1 other tissue See more
Orthologs
mouse all
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Genomic context

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See LRRC74B in Genome Data Viewer
Location:
22q11.21
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (21045946..21064168)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (21454733..21472942)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (21400235..21418457)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene microRNA 649 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:21395566-21395794 Neighboring gene purinergic receptor P2X 6 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:21406651-21407164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:21407165-21407676 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:21409882-21410414 Neighboring gene tubulin alpha 3g pseudogene Neighboring gene uncharacterized LOC112268300 Neighboring gene MPRA-validated peak4461 silencer

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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General gene information

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Markers

Homology

General protein information

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Preferred Names
leucine-rich repeat-containing protein 74B
Names
leucine-rich repeat-containing protein LOC400891

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291006.2 → NP_001277935.1  leucine-rich repeat-containing protein 74B

    See identical proteins and their annotated locations for NP_001277935.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the protein.
    Source sequence(s)
    AC002472
    Consensus CDS
    CCDS77654.1
    UniProtKB/Swiss-Prot
    Q6ZQY2
    Related
    ENSP00000394078.2, ENST00000442047.3
    Conserved Domains (2) summary
    sd00033
    Location:109 → 136
    LRR_RI; leucine-rich repeat [structural motif]
    cl42388
    Location:57 → 357
    PPP1R42; protein phosphatase 1 regulatory subunit 42

RNA

  1. NR_027006.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains multiple differences in the internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most [supported/expected] translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC002472, AK128646, BC028231, BC036220

  2. NR_110991.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains multiple differences in the internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most [supported/expected] translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC002472
    Related
    ENST00000497328.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    21045946..21064168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530175.2 → XP_011528477.1  leucine-rich repeat-containing protein 74B isoform X3

    See identical proteins and their annotated locations for XP_011528477.1

    Conserved Domains (2) summary
    cd00116
    Location:58 → 205
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:54 → 80
    LRR_RI; leucine-rich repeat [structural motif]

  2. XM_011530177.2 → XP_011528479.1  leucine-rich repeat-containing protein 74B isoform X3

    See identical proteins and their annotated locations for XP_011528479.1

    Conserved Domains (2) summary
    cd00116
    Location:58 → 205
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:54 → 80
    LRR_RI; leucine-rich repeat [structural motif]

  3. XM_011530176.3 → XP_011528478.1  leucine-rich repeat-containing protein 74B isoform X3

    See identical proteins and their annotated locations for XP_011528478.1

    Conserved Domains (2) summary
    cd00116
    Location:58 → 205
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:54 → 80
    LRR_RI; leucine-rich repeat [structural motif]

  4. XM_011530174.2 → XP_011528476.1  leucine-rich repeat-containing protein 74B isoform X3

    See identical proteins and their annotated locations for XP_011528476.1

    Conserved Domains (2) summary
    cd00116
    Location:58 → 205
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:54 → 80
    LRR_RI; leucine-rich repeat [structural motif]

  5. XM_047441362.1 → XP_047297318.1  leucine-rich repeat-containing protein 74B isoform X1

  6. XM_017028797.2 → XP_016884286.1  leucine-rich repeat-containing protein 74B isoform X2

RNA

  1. XR_937849.2 RNA Sequence

  2. XR_937851.2 RNA Sequence

  3. XR_937858.2 RNA Sequence

  4. XR_937847.2 RNA Sequence

  5. XR_937859.2 RNA Sequence

  6. XR_937862.2 RNA Sequence

  7. XR_937856.2 RNA Sequence

  8. XR_937861.2 RNA Sequence

  9. XR_937860.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    21454733..21472942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325610.1 → XP_054181585.1  leucine-rich repeat-containing protein 74B isoform X3

  2. XM_054325612.1 → XP_054181587.1  leucine-rich repeat-containing protein 74B isoform X3

  3. XM_054325611.1 → XP_054181586.1  leucine-rich repeat-containing protein 74B isoform X3

  4. XM_054325609.1 → XP_054181584.1  leucine-rich repeat-containing protein 74B isoform X3

  5. XM_054325607.1 → XP_054181582.1  leucine-rich repeat-containing protein 74B isoform X1

  6. XM_054325608.1 → XP_054181583.1  leucine-rich repeat-containing protein 74B isoform X2

RNA

  1. XR_008485388.1 RNA Sequence

  2. XR_008485389.1 RNA Sequence

  3. XR_008485391.1 RNA Sequence

  4. XR_008485387.1 RNA Sequence

  5. XR_008485392.1 RNA Sequence

  6. XR_008485395.1 RNA Sequence

  7. XR_008485390.1 RNA Sequence

  8. XR_008485394.1 RNA Sequence

  9. XR_008485393.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013675.1: Suppressed sequence

    Description
    NM_001013675.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZQY2.3 GenPept UniProtKB/Swiss-Prot:Q6ZQY2

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