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MED11 mediator complex subunit 11 [ Homo sapiens (human) ]

Gene ID: 400569, updated on 18-Aug-2020

Summary

Official Symbol
MED11provided by HGNC
Official Full Name
mediator complex subunit 11provided by HGNC
Primary source
HGNC:HGNC:32687
See related
Ensembl:ENSG00000161920 MIM:612383
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPC296
Summary
MED11 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]
Expression
Ubiquitous expression in kidney (RPKM 9.3), spleen (RPKM 8.7) and 25 other tissues See more
Orthologs

Genomic context

See MED11 in Genome Data Viewer
Location:
17p13.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (4731428..4733607)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4634723..4636902)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101559451 Neighboring gene ribosomal protein S12 pseudogene 29 Neighboring gene arrestin beta 2 Neighboring gene C-X-C motif chemokine ligand 16 Neighboring gene zinc finger MYND-type containing 15 Neighboring gene transmembrane 4 L six family member 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mediator complex subunit 11 (MED11) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Knockdown of MED11 by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC88387

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 11
Names
mediator of RNA polymerase II transcription, subunit 11 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001683.4NP_001001683.1  mediator of RNA polymerase II transcription subunit 11 isoform a

    See identical proteins and their annotated locations for NP_001001683.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC091153
    Consensus CDS
    CCDS32533.1
    UniProtKB/Swiss-Prot
    Q9P086
    Related
    ENSP00000293777.5, ENST00000293777.6
    Conserved Domains (1) summary
    pfam10280
    Location:8115
    Med11; Mediator complex protein
  2. NM_001305000.2NP_001291929.1  mediator of RNA polymerase II transcription subunit 11 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC091153
    Consensus CDS
    CCDS76920.1
    UniProtKB/Swiss-Prot
    Q9P086
    UniProtKB/TrEMBL
    I3L3E8
    Related
    ENSP00000460400.1, ENST00000575284.5
    Conserved Domains (1) summary
    pfam10280
    Location:872
    Med11; Mediator complex protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    4731428..4733607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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