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mark2.S microtubule affinity regulating kinase 2 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398441, updated on 18-Sep-2024

Summary

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Official Symbol
mark2.S
Official Full Name
microtubule affinity regulating kinase 2 S homeolog
Primary source
Xenbase:XB-GENE-876461
Locus tag
XELAEV_18024218mg
See related
EnsemblRapid:ENSXLAG00005009310
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
emk1; par1; emk-1; mark2; par-1; par1b; xpar-1b
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Genomic context

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Location:
chromosome: 4S
Exon count:
21
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4S NC_054378.1 (1853155..1918868)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4S NC_030731.1 (1856019..1914674)

Chromosome 4S - NC_054378.1Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 10, gene 2 S homeolog Neighboring gene provisional ortholog of Rab9 effector protein with kelch motifs S homeolog Neighboring gene REST corepressor 2 S homeolog Neighboring gene N(alpha)-acetyltransferase 40, NatD catalytic subunit S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning and developmental expression of Par-1/MARK homologues XPar-1A and XPar-1B from Xenopus laevis. Ossipova O, et al. Gene Expr Patterns, 2002 Nov. PMID 12617853
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables tau-protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
microtubule affinity regulating kinase 2 S homeolog
Names
MAP/microtubule affinity-regulating kinase 2 S homeolog
Ser/Thr protein kinase PAR-1B alpha
NP_001082392.1
XP_041447168.1
XP_041447169.1
XP_041447170.1
XP_041447171.1
XP_041447172.1
XP_041447173.1
XP_041447174.1
XP_041447175.1
XP_041447176.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001088923.1 → NP_001082392.1  microtubule affinity regulating kinase 2 S homeolog

    See identical proteins and their annotated locations for NP_001082392.1

    Status: PROVISIONAL

    Source sequence(s)
    AF509738
    UniProtKB/TrEMBL
    B7ZRP1, Q804T1
    Related
    ENSXLAP00005027685.1, ENSXLAT00005028419.1
    Conserved Domains (4) summary
    cd12201
    Location:681 → 779
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    smart00220
    Location:63 → 314
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14406
    Location:332 → 373
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:62 → 314
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054378.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    1853155..1918868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041591235.1 → XP_041447169.1  microtubule affinity regulating kinase 2 S homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J1N1U1, B7ZRP1
    Related
    ENSXLAP00005027729.1, ENSXLAT00005028463.1
    Conserved Domains (3) summary
    cd12201
    Location:683 → 781
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    cd14406
    Location:325 → 366
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:55 → 307
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

  2. XM_041591236.1 → XP_041447170.1  microtubule affinity regulating kinase 2 S homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J1N1U1, B7ZRP1
    Conserved Domains (3) summary
    cd12201
    Location:683 → 781
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    cd14406
    Location:325 → 366
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:55 → 307
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

  3. XM_041591239.1 → XP_041447173.1  microtubule affinity regulating kinase 2 S homeolog isoform X5

    UniProtKB/TrEMBL
    A0A8J1N123, B7ZRP1
    Related
    ENSXLAP00005027701.1, ENSXLAT00005028435.1
    Conserved Domains (3) summary
    cd12201
    Location:640 → 738
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    cd14406
    Location:332 → 373
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:62 → 314
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

  4. XM_041591241.1 → XP_041447175.1  microtubule affinity regulating kinase 2 S homeolog isoform X7

    UniProtKB/TrEMBL
    A0A8J1N1U8, B7ZRP1
    Related
    ENSXLAP00005027694.1, ENSXLAT00005028428.1
    Conserved Domains (3) summary
    cd12201
    Location:625 → 723
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    cd14406
    Location:332 → 373
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:62 → 314
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

  5. XM_041591242.1 → XP_041447176.1  microtubule affinity regulating kinase 2 S homeolog isoform X8

    UniProtKB/TrEMBL
    A0A8J1N0C0, B7ZRP1
    Conserved Domains (3) summary
    cd12201
    Location:616 → 714
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    cd14406
    Location:332 → 373
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:62 → 314
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

  6. XM_041591240.1 → XP_041447174.1  microtubule affinity regulating kinase 2 S homeolog isoform X6

    UniProtKB/TrEMBL
    A0A8J1MZ62, B7ZRP1
    Conserved Domains (3) summary
    cd12201
    Location:631 → 729
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    cd14406
    Location:332 → 373
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:62 → 314
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

  7. XM_041591234.1 → XP_041447168.1  microtubule affinity regulating kinase 2 S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1N118, B7ZRP1
    Related
    ENSXLAP00005027712.1, ENSXLAT00005028445.1
    Conserved Domains (3) summary
    cd12201
    Location:690 → 788
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    cd14406
    Location:332 → 373
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:62 → 314
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

  8. XM_041591237.1 → XP_041447171.1  microtubule affinity regulating kinase 2 S homeolog isoform X3

    UniProtKB/TrEMBL
    A0A8J1N0B4, B7ZRP1
    Conserved Domains (3) summary
    cd12201
    Location:675 → 773
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    cd14406
    Location:332 → 373
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:62 → 314
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

  9. XM_041591238.1 → XP_041447172.1  microtubule affinity regulating kinase 2 S homeolog isoform X4

    UniProtKB/TrEMBL
    A0A8J1MZF3, B7ZRP1
    Conserved Domains (3) summary
    cd12201
    Location:666 → 764
    MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
    cd14406
    Location:332 → 373
    UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
    cd14072
    Location:62 → 314
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
Nucleotide Protein Strain
Heading Accession and Version

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