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CAPN1 calpain 1 [ Sus scrofa (pig) ]

Gene ID: 397027, updated on 17-Aug-2024

Summary

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Official Symbol
CAPN1provided by VGNC
Official Full Name
calpain 1provided by VGNC
Primary source
VGNC:VGNC:86170
See related
Ensembl:ENSSSCG00000012999
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
CANP; CANP 1
Expression
Ubiquitous expression in lung (RPKM 28.8), spleen (RPKM 27.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
23
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 2 NC_010444.4 (6997513..7024410, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 2 NC_010444.3 (6129549..6155985, complement)

Chromosome 2 - NC_010444.4Genomic Context describing neighboring genes Neighboring gene DNA polymerase alpha 2, accessory subunit Neighboring gene solute carrier family 22 member 20 Neighboring gene 40S ribosomal protein S20 pseudogene Neighboring gene speedy/RINGO cell cycle regulator family member C Neighboring gene synoviolin 1 Neighboring gene mitochondrial ribosomal protein L49 Neighboring gene FAU ubiquitin like and ribosomal protein S30 fusion

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. [Analysis of SNPs in partial exons and 3'UTR of CAPN1 in porcine]. Yang XQ, et al. Yi Chuan, 2008 Jun. PMID 18550497
  2. Disulfide bond within mu-calpain active site inhibits activity and autolysis. Lametsch R, et al. Biochim Biophys Acta, 2008 Sep. PMID 18501725
  3. Calpain inhibition attenuates right ventricular contractile dysfunction after acute pressure overload. Greyson CR, et al. J Mol Cell Cardiol, 2008 Jan. PMID 18068185, Free PMC Article
  4. Rapid communication: Nucleotide sequences of two isoforms of porcine micromolar calcium-activated neutral protease 1 cDNA. Smith TP, et al. J Anim Sci, 2001 Feb. PMID 11219468
  5. Cloning the partial cDNAs of mu-calpain and m-calpain from porcine skeletal muscle. Sun W, et al. Biochimie, 1993. PMID 8312396

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CAPN1 HM535412:g.157T > C showed effect on meat redness.
    Title: Investigation on CAST, CAPN1 and CAPN3 porcine gene polymorphisms and expression in relation to post-mortem calpain activity in muscle and meat quality.
  2. The decreased expression of calpain 1A mRNA during development is highly correlated with muscle protein accumulation in neonatal Sus scrofa.
    Title: Decreased expression of calpain and calpastatin mRNA during development is highly correlated with muscle protein accumulation in neonatal pigs.
  3. Association of polymorphisms with breed characteristics indicated that the mutations in CAPN1 detected by P4, P6 primers and that resulting in the change of Hinf 1 recognition site may be related to lean meat percentage.
    Title: [Analysis of SNPs in partial exons and 3'UTR of CAPN1 in porcine].
  4. catalytic site amino acid residues 105-133 contained a disulfide bond between Cys(108) and Cys(115)
    Title: Disulfide bond within mu-calpain active site inhibits activity and autolysis.
  5. Right ventricular (RV) dysfunction from acute RV pressure overload is, in part, due to activation of calpain, and calpain inhibition would therefore attenuate RV dysfunction.
    Title: Calpain inhibition attenuates right ventricular contractile dysfunction after acute pressure overload.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calpain-1 catalytic subunit
Names
calcium activated neutral protease
calcium-activated neutral protease 1
calcium-activated neutral proteinase 1
calpain 1 large subunit
calpain mu-type
micromolar calcium-activated neutral protease 1
micromolar-calpain
NP_001335713.1
XP_005660759.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348784.2 → NP_001335713.1  calpain-1 catalytic subunit

    Status: VALIDATED

    Source sequence(s)
    AEMK02000006
    UniProtKB/Swiss-Prot
    P35750, Q29600, Q9N0M6
    UniProtKB/TrEMBL
    A0A8D1YCF2
    Related
    ENSSSCP00000013824.3, ENSSSCT00000014210.5
    Conserved Domains (3) summary
    cd00214
    Location:366 → 524
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:56 → 352
    Peptidase_C2; Calpain family cysteine protease
    cd16198
    Location:546 → 714
    EFh_PEF_CAPN1; Penta-EF hand, calcium binding motifs, found in mu-type calpain (CAPN1)

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010444.4 Reference Sscrofa11.1 Primary Assembly

    Range
    6997513..7024410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005660702.3 → XP_005660759.1  calpain-1 catalytic subunit isoform X1

    See identical proteins and their annotated locations for XP_005660759.1

    UniProtKB/Swiss-Prot
    P35750, Q29600, Q9N0M6
    UniProtKB/TrEMBL
    A0A8D1YCF2
    Conserved Domains (3) summary
    cd00214
    Location:366 → 524
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:56 → 352
    Peptidase_C2; Calpain family cysteine protease
    cd16198
    Location:546 → 714
    EFh_PEF_CAPN1; Penta-EF hand, calcium binding motifs, found in mu-type calpain (CAPN1)

RNA

  1. XR_002340872.1 RNA Sequence

  2. XR_002340871.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_213972.1: Suppressed sequence

    Description
    NM_213972.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35750.3 GenPept UniProtKB/Swiss-Prot:P35750

Gene LinkOut

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