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Capn1 calpain 1 [ Mus musculus (house mouse) ]

Gene ID: 12333, updated on 5-Jan-2022

Summary

Official Symbol
Capn1provided by MGI
Official Full Name
calpain 1provided by MGI
Primary source
MGI:MGI:88263
See related
Ensembl:ENSMUSG00000024942
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Capa1; Capa-1; mu-calpin
Summary
Enables calcium-dependent cysteine-type endopeptidase activity. Acts upstream of or within mammary gland involution; proteolysis; and receptor catabolic process. Located in cytosol; lysosome; and mitochondrion. Is expressed in molar; oral region epithelium; and skin. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 76. Orthologous to human CAPN1 (calpain 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in large intestine adult (RPKM 48.9), bladder adult (RPKM 44.0) and 24 other tissues See more
Orthologs
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Genomic context

See Capn1 in Genome Data Viewer
Location:
19 A; 19 4.34 cM
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6038573..6065855, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5988545..6015825, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (5988545..6015825, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene polymerase (DNA directed), alpha 2 Neighboring gene solute carrier family 22 (organic anion transporter), member 20 Neighboring gene predicted gene, 31719 Neighboring gene predicted gene 10814 Neighboring gene predicted gene, 19505 Neighboring gene thymosin, beta 10 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables calcium-dependent cysteine-type endopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cornified envelope IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
calpain-1 catalytic subunit
Names
CANP 1
calcium-activated neutral proteinase 1
calpain mu-type
calpain-1 large subunit
micromolar-calpain
mu-calpain
muCANP
NP_001103974.1
NP_031626.1
XP_036017307.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110504.1NP_001103974.1  calpain-1 catalytic subunit

    See identical proteins and their annotated locations for NP_001103974.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK149090, AK160940, AK171405, AW457044, BY034288
    Consensus CDS
    CCDS37893.1
    UniProtKB/Swiss-Prot
    O35350
    UniProtKB/TrEMBL
    Q3TB79, Q3TI07, Q3UF24
    Related
    ENSMUSP00000127498.2, ENSMUST00000164843.10
    Conserved Domains (6) summary
    PTZ00184
    Location:537680
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:589643
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:56352
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:366518
    Calpain_III; Calpain large subunit, domain III
    pfam13833
    Location:556609
    EF-hand_8; EF-hand domain pair
    cl08302
    Location:622704
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. NM_007600.3NP_031626.1  calpain-1 catalytic subunit

    See identical proteins and their annotated locations for NP_031626.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK149090, AK160940, AW457044, CJ078846
    Consensus CDS
    CCDS37893.1
    UniProtKB/Swiss-Prot
    O35350
    UniProtKB/TrEMBL
    Q3TI07, Q3UF24
    Related
    ENSMUSP00000025891.9, ENSMUST00000025891.11
    Conserved Domains (6) summary
    PTZ00184
    Location:537680
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:589643
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:56352
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:366518
    Calpain_III; Calpain large subunit, domain III
    pfam13833
    Location:556609
    EF-hand_8; EF-hand domain pair
    cl08302
    Location:622704
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6038573..6065855 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161414.1XP_036017307.1  calpain-1 catalytic subunit isoform X1

    Conserved Domains (4) summary
    cd00214
    Location:366523
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd15897
    Location:545573
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:545647
    EFh_PEF; The penta-EF hand (PEF) family
    pfam00648
    Location:56352
    Peptidase_C2; Calpain family cysteine protease
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