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ARHGDIB Rho GDP dissociation inhibitor beta [ Homo sapiens (human) ]

Gene ID: 397, updated on 7-Dec-2018

Summary

Official Symbol
ARHGDIBprovided by HGNC
Official Full Name
Rho GDP dissociation inhibitor betaprovided by HGNC
Primary source
HGNC:HGNC:679
See related
Ensembl:ENSG00000111348 MIM:602843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1; RhoGDI2
Summary
Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]
Expression
Broad expression in bone marrow (RPKM 324.5), lymph node (RPKM 244.8) and 19 other tissues See more
Orthologs

Genomic context

See ARHGDIB in Genome Data Viewer
Location:
12p12.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (14942015..14961770, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (15094949..15114562, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene matrix Gla protein Neighboring gene endoplasmic reticulum protein 27 Neighboring gene uncharacterized LOC105369670 Neighboring gene phosphodiesterase 6H Neighboring gene long intergenic non-protein coding RNA 1489

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr The proteomic assay from Vpr-expressing HTLV-1 transformed cells reveals apoptosis related protein changes, such as CASP3 activity indicator proteins (vimentin and Rho GDP-dissociation inhibitor 2) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Caspase cascade in apoptosis, organism-specific biosystem (from Pathway Interaction Database)
    Caspase cascade in apoptosis, organism-specific biosystem
    Caspase cascade in apoptosis
  • Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation, organism-specific biosystem (from WikiPathways)
    Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
  • G13 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    G13 Signaling Pathway, organism-specific biosystemThe G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cell...
  • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
    Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
    Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Regulation of RhoA activity, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of RhoA activity, organism-specific biosystem
    Regulation of RhoA activity
  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • Vasopressin-regulated water reabsorption, organism-specific biosystem (from KEGG)
    Vasopressin-regulated water reabsorption, organism-specific biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...
  • Vasopressin-regulated water reabsorption, conserved biosystem (from KEGG)
    Vasopressin-regulated water reabsorption, conserved biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Rac GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rac GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
Rho GDP-dissociation inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rho GDP-dissociation inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytoplasmic vesicle TAS
Traceable Author Statement
more info
PubMed 
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
rho GDP-dissociation inhibitor 2
Names
Rho GDI 2
Rho GDP dissociation inhibitor (GDI) beta
rho-GDI beta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001175.7NP_001166.3  rho GDP-dissociation inhibitor 2

    See identical proteins and their annotated locations for NP_001166.3

    Status: VALIDATED

    Source sequence(s)
    BC009200, BM849963, BY996333
    Consensus CDS
    CCDS8671.1
    UniProtKB/Swiss-Prot
    P52566
    UniProtKB/TrEMBL
    A0A024RAS5
    Related
    ENSP00000228945.4, ENST00000228945.8
    Conserved Domains (1) summary
    pfam02115
    Location:23198
    Rho_GDI; RHO protein GDP dissociation inhibitor
  2. NM_001321420.1NP_001308349.1  rho GDP-dissociation inhibitor 2

    Status: VALIDATED

    Source sequence(s)
    BC009200, BG390701, BI762648, BP355037, BQ213418
    Consensus CDS
    CCDS8671.1
    UniProtKB/Swiss-Prot
    P52566
    UniProtKB/TrEMBL
    A0A024RAS5
    Related
    ENSP00000440560.1, ENST00000541546.5
    Conserved Domains (1) summary
    pfam02115
    Location:23198
    Rho_GDI; RHO protein GDP dissociation inhibitor
  3. NM_001321421.1NP_001308350.1  rho GDP-dissociation inhibitor 2

    Status: VALIDATED

    Source sequence(s)
    AC007655, AV685495, AV717900, BC009200, BM849963, BY996333
    Consensus CDS
    CCDS8671.1
    UniProtKB/Swiss-Prot
    P52566
    UniProtKB/TrEMBL
    A0A024RAS5
    Conserved Domains (1) summary
    pfam02115
    Location:23198
    Rho_GDI; RHO protein GDP dissociation inhibitor
  4. NM_001321422.1NP_001308351.1  rho GDP-dissociation inhibitor 2

    Status: VALIDATED

    Source sequence(s)
    AC007655, BC009200, BM849963, BY996333, CD385175
    Consensus CDS
    CCDS8671.1
    UniProtKB/Swiss-Prot
    P52566
    UniProtKB/TrEMBL
    A0A024RAS5
    Conserved Domains (1) summary
    pfam02115
    Location:23198
    Rho_GDI; RHO protein GDP dissociation inhibitor
  5. NM_001321423.1NP_001308352.1  rho GDP-dissociation inhibitor 2

    Status: VALIDATED

    Source sequence(s)
    BC009200, BE744996, BM849963, BY996333, CD385175
    Consensus CDS
    CCDS8671.1
    UniProtKB/Swiss-Prot
    P52566
    UniProtKB/TrEMBL
    A0A024RAS5
    Related
    ENSP00000444860.1, ENST00000541644.5
    Conserved Domains (1) summary
    pfam02115
    Location:23198
    Rho_GDI; RHO protein GDP dissociation inhibitor

RNA

  1. NR_135637.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC009200, BM849963, BP365648, BY996333

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    14942015..14961770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448979.1XP_024304747.1  rho GDP-dissociation inhibitor 2 isoform X1

    Conserved Domains (1) summary
    pfam02115
    Location:23198
    Rho_GDI; RHO protein GDP dissociation inhibitor
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