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Arhgdib Rho, GDP dissociation inhibitor beta [ Mus musculus (house mouse) ]

Gene ID: 11857, updated on 8-Feb-2024

Summary

Official Symbol
Arhgdibprovided by MGI
Official Full Name
Rho, GDP dissociation inhibitor betaprovided by MGI
Primary source
MGI:MGI:101940
See related
Ensembl:ENSMUSG00000030220 AllianceGenome:MGI:101940
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D4; Gdid4; Ly-GDI
Summary
The protein encoded by this gene is a member of the Rho guanine nucleotide dissociation inhibitor (GDI) family. This gene is expressed at high levels in hematopoietic cells. This protein is cytosolic, and dissociation of Rho from this protein is required for membrane association and activation of Rho by Guanine Nucleotide Exchange Factors (GEFs). C-terminal truncations of this gene product have been reported to promote metastasis. Multiple transcript variants and protein isoforms exist. [provided by RefSeq, Aug 2014]
Expression
Biased expression in thymus adult (RPKM 157.4), spleen adult (RPKM 123.8) and 13 other tissues See more
Orthologs
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Genomic context

See Arhgdib in Genome Data Viewer
Location:
6 G1; 6 66.72 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (136900653..136918895, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (136923655..136941899, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene matrix Gla protein Neighboring gene endoplasmic reticulum protein 27 Neighboring gene STARR-seq mESC enhancer starr_17614 Neighboring gene STARR-positive B cell enhancer ABC_E3690 Neighboring gene phosphodiesterase 6H, cGMP-specific, cone, gamma Neighboring gene STARR-positive B cell enhancer ABC_E9680 Neighboring gene STARR-positive B cell enhancer mm9_chr6:136929021-136929322 Neighboring gene predicted gene, 30055

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables Rho GDP-dissociation inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Rho GDP-dissociation inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of trophoblast cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
rho GDP-dissociation inhibitor 2
Names
Rho, GDP dissociation inhibitor (GDI) beta
rho GDI 2
rho-GDI beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301301.2NP_001288230.1  rho GDP-dissociation inhibitor 2 isoform 1

    See identical proteins and their annotated locations for NP_001288230.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, compared to variant 1. Variants 1-4 and 7-16 all encode the same isoform (1).
    Source sequence(s)
    AC125341
    Consensus CDS
    CCDS20661.1
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599
    Related
    ENSMUSP00000107522.2, ENSMUST00000111891.4
    Conserved Domains (1) summary
    pfam02115
    Location:7197
    Rho_GDI; RHO protein GDP dissociation inhibitor
  2. NM_001301303.2NP_001288232.1  rho GDP-dissociation inhibitor 2 isoform 1

    See identical proteins and their annotated locations for NP_001288232.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR compared to variant 1. Variants 1-4 and 7-16 all encode the same isoform (1).
    Source sequence(s)
    AC125341
    Consensus CDS
    CCDS20661.1
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599
    Conserved Domains (1) summary
    pfam02115
    Location:7197
    Rho_GDI; RHO protein GDP dissociation inhibitor
  3. NM_001301305.2NP_001288234.1  rho GDP-dissociation inhibitor 2 isoform 1

    See identical proteins and their annotated locations for NP_001288234.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 5' UTR compared to variant 1. Variants 1-4 and 7-16 all encode the same isoform (1).
    Source sequence(s)
    AC125341
    Consensus CDS
    CCDS20661.1
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599
    Related
    ENSMUSP00000107523.2, ENSMUST00000111892.8
    Conserved Domains (1) summary
    pfam02115
    Location:7197
    Rho_GDI; RHO protein GDP dissociation inhibitor
  4. NM_001301308.2NP_001288237.1  rho GDP-dissociation inhibitor 2 isoform 2

    See identical proteins and their annotated locations for NP_001288237.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an in-frame exon in the coding region and uses a downstream start codon compared to variant 1. Variants 5, 6, and 17-20 all encode isoform 2, which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q61599
    Conserved Domains (1) summary
    pfam02115
    Location:1114
    Rho_GDI; RHO protein GDP dissociation inhibitor
  5. NM_001301309.2NP_001288238.1  rho GDP-dissociation inhibitor 2 isoform 2

    See identical proteins and their annotated locations for NP_001288238.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an in-frame exon in the coding region and uses a downstream start codon compared to variant 1. Variants 5, 6, and 17-20 all encode isoform 2, which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q61599
    Conserved Domains (1) summary
    pfam02115
    Location:1114
    Rho_GDI; RHO protein GDP dissociation inhibitor
  6. NM_001409490.1NP_001396419.1  rho GDP-dissociation inhibitor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599
  7. NM_001409491.1NP_001396420.1  rho GDP-dissociation inhibitor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599
  8. NM_001409492.1NP_001396421.1  rho GDP-dissociation inhibitor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599
  9. NM_001409493.1NP_001396422.1  rho GDP-dissociation inhibitor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599
  10. NM_001409494.1NP_001396423.1  rho GDP-dissociation inhibitor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599
  11. NM_001409495.1NP_001396424.1  rho GDP-dissociation inhibitor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599
  12. NM_001409497.1NP_001396426.1  rho GDP-dissociation inhibitor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599
  13. NM_001409498.1NP_001396427.1  rho GDP-dissociation inhibitor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599
  14. NM_001409499.1NP_001396428.1  rho GDP-dissociation inhibitor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599
  15. NM_001409500.1NP_001396429.1  rho GDP-dissociation inhibitor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599
  16. NM_001409501.1NP_001396430.1  rho GDP-dissociation inhibitor 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125341
  17. NM_001409502.1NP_001396431.1  rho GDP-dissociation inhibitor 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125341
  18. NM_001409503.1NP_001396432.1  rho GDP-dissociation inhibitor 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125341
  19. NM_001409504.1NP_001396433.1  rho GDP-dissociation inhibitor 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125341
  20. NM_007486.6NP_031512.1  rho GDP-dissociation inhibitor 2 isoform 1

    See identical proteins and their annotated locations for NP_031512.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1-4 and 7-16 all encode the same isoform (1).
    Source sequence(s)
    AC125341
    Consensus CDS
    CCDS20661.1
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599
    Related
    ENSMUSP00000032344.6, ENSMUST00000032344.12
    Conserved Domains (1) summary
    pfam02115
    Location:7197
    Rho_GDI; RHO protein GDP dissociation inhibitor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    136900653..136918895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255118.2XP_030110978.1  rho GDP-dissociation inhibitor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599
    Conserved Domains (1) summary
    pfam02115
    Location:7197
    Rho_GDI; RHO protein GDP dissociation inhibitor