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LAMB1 laminin subunit beta 1 [ Homo sapiens (human) ]

Gene ID: 3912, updated on 24-Nov-2020

Summary

Official Symbol
LAMB1provided by HGNC
Official Full Name
laminin subunit beta 1provided by HGNC
Primary source
HGNC:HGNC:6486
See related
Ensembl:ENSG00000091136 MIM:150240
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLM; LIS5
Summary
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq, Aug 2011]
Expression
Broad expression in placenta (RPKM 75.7), fat (RPKM 65.2) and 23 other tissues See more
Orthologs

Genomic context

See LAMB1 in Genome Data Viewer
Location:
7q31.1
Exon count:
35
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (107923799..108003176, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (107564244..107643804, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375445 Neighboring gene dihydrolipoamide dehydrogenase Neighboring gene VISTA enhancer hs2081 Neighboring gene uncharacterized LOC107986834 Neighboring gene laminin subunit beta 4 Neighboring gene uncharacterized LOC107986835

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study identifies susceptibility loci of silica related pneumoconiosis in Han Chinese.
GeneReviews: Not available
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
GeneReviews: Not available
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
GeneReviews: Not available
Lissencephaly 5
MedGen: C3554657 OMIM: 615191 GeneReviews: Not available
Compare labs
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
GeneReviews: Not available
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Treatment with cannabinoids inhibits HIV-1 Tat-enhanced attachment of U937 cells to collagen IV, laminin, or ECM1 proteins, which is linked to the cannabinoid receptor type 2 and the modulation of beta1-integrin and actin distribution PubMed
tat HIV-1 Tat enhances adhesion of human U937 monocyte-like cells to proteins of the extracellular matrix, such as collagen IV, laminin, and ECM1 PubMed
tat HIV-1 Tat upregulates the expression of extracellular matrix proteins, including the major basement membrane protein laminin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC142015

Gene Ontology Provided by GOA

Function Evidence Code Pubs
extracellular matrix structural constituent IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular matrix structural constituent IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix structural constituent ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
basement membrane assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
endodermal cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
neuronal-glial interaction involved in cerebral cortex radial glia guided migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
odontogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial cell proliferation TAS
Traceable Author Statement
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
tissue development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
basement membrane TAS
Traceable Author Statement
more info
PubMed 
collagen-containing extracellular matrix HDA PubMed 
colocalizes_with collagen-containing extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
laminin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
laminin-1 complex IDA
Inferred from Direct Assay
more info
PubMed 
laminin-1 complex IPI
Inferred from Physical Interaction
more info
PubMed 
laminin-1 complex TAS
Traceable Author Statement
more info
PubMed 
laminin-10 complex IDA
Inferred from Direct Assay
more info
PubMed 
laminin-2 complex IDA
Inferred from Direct Assay
more info
PubMed 
laminin-2 complex TAS
Traceable Author Statement
more info
PubMed 
laminin-8 complex IDA
Inferred from Direct Assay
more info
PubMed 
laminin-8 complex TAS
Traceable Author Statement
more info
PubMed 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
laminin subunit beta-1
Names
laminin B1 chain
laminin, beta 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023255.1 RefSeqGene

    Range
    5199..84561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002291.3NP_002282.2  laminin subunit beta-1 precursor

    See identical proteins and their annotated locations for NP_002282.2

    Status: REVIEWED

    Source sequence(s)
    AC005046, BC026018, BC113455, DA861108
    Consensus CDS
    CCDS5750.1
    UniProtKB/Swiss-Prot
    P07942
    UniProtKB/TrEMBL
    Q8TAS6
    Related
    ENSP00000222399.6, ENST00000222399.11
    Conserved Domains (8) summary
    smart00180
    Location:773818
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:457508
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:821869
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:44269
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam15704
    Location:14721688
    Mt_ATP_synt; Mitochondrial ATP synthase subunit
    pfam16731
    Location:15381726
    GARP; Glutamic acid/alanine-rich protein of Trypanosoma
    cl09111
    Location:16491766
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    cl09820
    Location:12511380
    PhaP_Bmeg; Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    107923799..108003176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012201.1XP_016867690.1  laminin subunit beta-1 isoform X1

    UniProtKB/TrEMBL
    G3XAI2
    Related
    ENSP00000377191.1, ENST00000393561.5
    Conserved Domains (8) summary
    smart00180
    Location:797842
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:533572
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:845893
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:68293
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam15704
    Location:14961712
    Mt_ATP_synt; Mitochondrial ATP synthase subunit
    pfam16731
    Location:15621750
    GARP; Glutamic acid/alanine-rich protein of Trypanosoma
    cl09111
    Location:16731790
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    cl09820
    Location:12751404
    PhaP_Bmeg; Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg)
  2. XM_017012202.1XP_016867691.1  laminin subunit beta-1 isoform X2

RNA

  1. XR_001744756.1 RNA Sequence

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