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PLA2G2C phospholipase A2 group IIC [ Homo sapiens (human) ]

Gene ID: 391013, updated on 26-Oct-2022

Summary

Official Symbol
PLA2G2Cprovided by HGNC
Official Full Name
phospholipase A2 group IICprovided by HGNC
Primary source
HGNC:HGNC:9032
See related
Ensembl:ENSG00000187980 AllianceGenome:HGNC:9032
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBXN10-AS1
Summary
Predicted to enable calcium ion binding activity; calcium-dependent phospholipase A2 activity; and phospholipid binding activity. Predicted to be involved in phospholipid metabolic process. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See PLA2G2C in Genome Data Viewer
Location:
1p36.12
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (20163055..20186518, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (19986700..20010162, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20489548..20513011, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phospholipase A2 group IIF Neighboring gene uncharacterized LOC117779438 Neighboring gene UBX domain protein 10 Neighboring gene uncharacterized LOC105376825 Neighboring gene uncharacterized LOC105376826

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish fusion PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in arachidonic acid secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylcholine metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
putative inactive group IIC secretory phospholipase A2
Names
UBXN10 antisense RNA 1
phosphatidylcholine 2-acylhydrolase-like protein GIIC
phospholipase A2, group IIC (possible pseudogene)
NP_001303651.1
NP_001354898.1
XP_047276172.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316722.3NP_001303651.1  putative inactive group IIC secretory phospholipase A2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    Z98257
    Conserved Domains (1) summary
    pfam00068
    Location:22132
    Phospholip_A2_1; Phospholipase A2
  2. NM_001367969.2NP_001354898.1  putative inactive group IIC secretory phospholipase A2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    Z98257
    Consensus CDS
    CCDS90872.1
    UniProtKB/Swiss-Prot
    Q7M4M6
    Related
    ENSP00000504292.1, ENST00000679259.1

RNA

  1. NR_110078.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    Z98257
    Related
    ENST00000442226.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    20163055..20186518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420216.1XP_047276172.1  putative inactive group IIC secretory phospholipase A2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    19986700..20010162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001105572.1: Suppressed sequence

    Description
    NM_001105572.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.