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PLA2G2C phospholipase A2 group IIC [ Homo sapiens (human) ]

Gene ID: 391013, updated on 24-Nov-2020

Summary

Official Symbol
PLA2G2Cprovided by HGNC
Official Full Name
phospholipase A2 group IICprovided by HGNC
Primary source
HGNC:HGNC:9032
See related
Ensembl:ENSG00000187980 Ensembl:ENSG00000225986
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBXN10-AS1
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See PLA2G2C in Genome Data Viewer
Location:
1p36.12
Exon count:
7
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (20163055..20186518, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20490484..20501687, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phospholipase A2 group IIF Neighboring gene uncharacterized LOC117779438 Neighboring gene UBX domain protein 10 Neighboring gene uncharacterized LOC105376825 Neighboring gene uncharacterized LOC105376826

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish fusion PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
arachidonic acid secretion IEA
Inferred from Electronic Annotation
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
putative inactive group IIC secretory phospholipase A2
Names
UBXN10 antisense RNA 1
phosphatidylcholine 2-acylhydrolase-like protein GIIC
phospholipase A2, group IIC (possible pseudogene)
NP_001303651.1
NP_001354898.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316722.3NP_001303651.1  putative inactive group IIC secretory phospholipase A2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    Z98257
    Conserved Domains (1) summary
    pfam00068
    Location:22132
    Phospholip_A2_1; Phospholipase A2
  2. NM_001367969.2NP_001354898.1  putative inactive group IIC secretory phospholipase A2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    Z98257
    Related
    ENSP00000389335.2, ENST00000429261.2

RNA

  1. NR_110078.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA683341, AI651649, AW970795, BX106299
    Related
    ENST00000442226.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    20163055..20186518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001105572.1: Suppressed sequence

    Description
    NM_001105572.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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