Pla2g2c phospholipase A2, group IIC [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pla2g2cprovided by MGI
Official Full Name: phospholipase A2, group IICprovided by MGI
Primary source: MGI:MGI:106638
See related: Ensembl:ENSMUSG00000028750 AllianceGenome:MGI:106638
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable calcium ion binding activity; calcium-dependent phospholipase A2 activity; and phospholipid binding activity. Predicted to be involved in phospholipid metabolic process. Predicted to act upstream of or within phospholipid catabolic process. Predicted to be located in extracellular region. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human PLA2G2C (phospholipase A2 group IIC). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 51.3) See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 70.54 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (138452636..138471886)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (138725325..138744575)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Markers

Pla2g2c (e-PCR), detects polymorphism
- UniSTS:144211

U18119 (e-PCR)
- UniSTS:125685

Homology

Orthologs from Annotation Pipeline: 182 organisms have orthologs with human gene Pla2g2c
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables calcium-dependent phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables calcium-dependent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipase A2 activity	ISO Inferred from Sequence Orthology more info	PubMed
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in arachidonic acid secretion	IEA Inferred from Electronic Annotation more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phospholipid catabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of fibroblast proliferation	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: group IIC secretory phospholipase A2

Names: 14 kDa phospholipase A2; GIIC sPLA2; PLA2-8; phosphatidylcholine 2-acylhydrolase 2C; sPLA2-IIC

NP_032894.2

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.