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RHOG ras homolog family member G [ Homo sapiens (human) ]

Gene ID: 391, updated on 19-Jul-2021

Summary

Official Symbol
RHOGprovided by HGNC
Official Full Name
ras homolog family member Gprovided by HGNC
Primary source
HGNC:HGNC:672
See related
Ensembl:ENSG00000177105 MIM:179505
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARHG
Summary
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011]
Expression
Broad expression in bone marrow (RPKM 74.8), spleen (RPKM 41.3) and 24 other tissues See more
Orthologs
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Genomic context

See RHOG in Genome Data Viewer
Location:
11p15.4
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (3826978..3840959, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (3848208..3862189, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene nucleoporin 98 and 96 precursor Neighboring gene RNA, U7 small nuclear 50 pseudogene Neighboring gene post-GPI attachment to proteins 2 Neighboring gene STIM1 antisense RNA 1 Neighboring gene microRNA 4687 Neighboring gene stromal interaction molecule 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr-expressing Jurkat T cell clones showed a significant upregulation of RhoG expression PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC125835, MGC125836

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in Rac protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within Rac protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within Rho protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in activation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cortical cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in engulfment of apoptotic cell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in motor neuron axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of neutrophil migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of ruffle assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cell projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in focal adhesion HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in secretory granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
rho-related GTP-binding protein RhoG
Names
ras homolog gene family, member G (rho G)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001665.4NP_001656.2  rho-related GTP-binding protein RhoG

    See identical proteins and their annotated locations for NP_001656.2

    Status: VALIDATED

    Source sequence(s)
    AA424888, BC104178, CB125569
    Consensus CDS
    CCDS7748.1
    UniProtKB/Swiss-Prot
    P84095
    UniProtKB/TrEMBL
    Q6ICQ8
    Related
    ENSP00000339467.4, ENST00000351018.5
    Conserved Domains (1) summary
    cd01875
    Location:1191
    RhoG; Ras homolog family, member G (RhoG) of small guanosine triphosphatases (GTPases)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    3826978..3840959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252916.2XP_005252973.1  rho-related GTP-binding protein RhoG isoform X1

    See identical proteins and their annotated locations for XP_005252973.1

    UniProtKB/Swiss-Prot
    P84095
    UniProtKB/TrEMBL
    Q6ICQ8
    Related
    ENSP00000380175.1, ENST00000396978.1
    Conserved Domains (1) summary
    cd01875
    Location:1191
    RhoG; Ras homolog family, member G (RhoG) of small guanosine triphosphatases (GTPases)
  2. XM_017017719.1XP_016873208.1  rho-related GTP-binding protein RhoG isoform X1

    UniProtKB/Swiss-Prot
    P84095
    UniProtKB/TrEMBL
    Q6ICQ8
    Related
    ENSP00000436932.1, ENST00000533217.1
    Conserved Domains (1) summary
    cd01875
    Location:1191
    RhoG; Ras homolog family, member G (RhoG) of small guanosine triphosphatases (GTPases)
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