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PSMG4 proteasome assembly chaperone 4 [ Homo sapiens (human) ]

Gene ID: 389362, updated on 11-Jun-2021

Summary

Official Symbol
PSMG4provided by HGNC
Official Full Name
proteasome assembly chaperone 4provided by HGNC
Primary source
HGNC:HGNC:21108
See related
Ensembl:ENSG00000180822 MIM:617550
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAC4; C6orf86; bA506K6.2
Expression
Ubiquitous expression in thyroid (RPKM 1.1), prostate (RPKM 1.0) and 25 other tissues See more
Orthologs
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Genomic context

See PSMG4 in Genome Data Viewer
Location:
6p25.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (3254325..3308224)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (3259181..3268283)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100422781 Neighboring gene tubulin beta 2B class IIb Neighboring gene solute carrier family 22 member 23 Neighboring gene VISTA enhancer hs1391 Neighboring gene Sharpr-MPRA regulatory region 2671

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein-containing complex binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in proteasome assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of protein-containing complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
proteasome assembly chaperone 4
Names
PAC-4
hPAC4
proteasome (prosome, macropain) assembly chaperone 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128591.2NP_001122063.1  proteasome assembly chaperone 4 isoform b

    See identical proteins and their annotated locations for NP_001122063.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the mid-coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AA948231, AL445309, BM846556, CN429483
    Consensus CDS
    CCDS47361.1
    UniProtKB/Swiss-Prot
    Q5JS54
    Related
    ENSP00000413353.3, ENST00000438998.7
    Conserved Domains (1) summary
    pfam16093
    Location:3097
    PAC4; Proteasome assembly chaperone 4
  2. NM_001128592.2NP_001122064.1  proteasome assembly chaperone 4 isoform a

    See identical proteins and their annotated locations for NP_001122064.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AA948231, AL445309, BM738331, BM846556
    Consensus CDS
    CCDS47360.1
    UniProtKB/Swiss-Prot
    Q5JS54
    Related
    ENSP00000392353.2, ENST00000419065.6
    Conserved Domains (1) summary
    pfam16093
    Location:30136
    PAC4; Proteasome assembly chaperone 4
  3. NM_001135750.2NP_001129222.1  proteasome assembly chaperone 4 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks 3' two exons but has an alternate 3' sequence, compared to variant 1, resulting in an isoform (c) that is shorter and has a different C-terminus than isoform a.
    Source sequence(s)
    AL445309, BM846556, DA093618
    Consensus CDS
    CCDS47362.1
    UniProtKB/Swiss-Prot
    Q5JS54
    Related
    ENSP00000418241.2, ENST00000473000.2
    Conserved Domains (1) summary
    pfam16093
    Location:3085
    PAC4; Proteasome assembly chaperone 4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    3254325..3308224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514595.2XP_011512897.1  proteasome assembly chaperone 4 isoform X4

  2. XM_011514591.3XP_011512893.1  proteasome assembly chaperone 4 isoform X1

    See identical proteins and their annotated locations for XP_011512893.1

    Conserved Domains (1) summary
    pfam16093
    Location:2397
    PAC4; Proteasome assembly chaperone 4
  3. XM_011514593.3XP_011512895.1  proteasome assembly chaperone 4 isoform X2

    Conserved Domains (1) summary
    pfam16093
    Location:3084
    PAC4; Proteasome assembly chaperone 4
  4. XM_011514594.3XP_011512896.1  proteasome assembly chaperone 4 isoform X3

    UniProtKB/TrEMBL
    D6RB92
    Related
    ENSP00000424330.1, ENST00000324987.4
    Conserved Domains (1) summary
    pfam16093
    Location:3085
    PAC4; Proteasome assembly chaperone 4
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