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KRT19 keratin 19 [ Homo sapiens (human) ]

Gene ID: 3880, updated on 3-Jun-2018
Official Symbol
KRT19provided by HGNC
Official Full Name
keratin 19provided by HGNC
Primary source
HGNC:HGNC:6436
See related
Ensembl:ENSG00000171345 MIM:148020; Vega:OTTHUMG00000133422
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K19; CK19; K1CS
Summary
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
Expression
Biased expression in colon (RPKM 351.9), stomach (RPKM 332.4) and 13 other tissues See more
Orthologs
See KRT19 in Genome Data Viewer
Location:
17q21.2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (41523617..41528389, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39679869..39684641, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 13 Neighboring gene keratin 15 Neighboring gene microRNA 6510 Neighboring gene long intergenic non-protein coding RNA 974 Neighboring gene keratin 9

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Keratinization, organism-specific biosystem (from REACTOME)
    Keratinization, organism-specific biosystemKeratins are the major structural protein of vertebrate epidermis, constituting up to 85% of a fully differentiated keratinocyte (Fuchs 1995). Keratins belong to a superfamily of intermediate filamen...
  • Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem (from Pathway Interaction Database)
    Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem
    Signaling mediated by p38-alpha and p38-beta
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC15366

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
structural constituent of muscle IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell differentiation involved in embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
cornification TAS
Traceable Author Statement
more info
 
keratinization TAS
Traceable Author Statement
more info
 
response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
sarcomere organization IDA
Inferred from Direct Assay
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Z disc IEA
Inferred from Electronic Annotation
more info
 
apicolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
costamere IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dystrophin-associated glycoprotein complex IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
intermediate filament IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
sarcolemma IEA
Inferred from Electronic Annotation
more info
 
terminal web IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
keratin, type I cytoskeletal 19
Names
40-kDa keratin intermediate filament
CK-19
cytokeratin 19
keratin 19, type I
keratin, type I, 40-kd

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012285.1 RefSeqGene

    Range
    5001..9773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002276.4NP_002267.2  keratin, type I cytoskeletal 19

    See identical proteins and their annotated locations for NP_002267.2

    Status: REVIEWED

    Source sequence(s)
    BC007628, BG490639, BP328445, DA068330
    Consensus CDS
    CCDS11399.1
    UniProtKB/Swiss-Prot
    P08727
    Related
    ENSP00000355124.3, OTTHUMP00000164620, ENST00000361566.7, OTTHUMT00000257285
    Conserved Domains (1) summary
    pfam00038
    Location:79390
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    41523617..41528389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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