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Krt19 keratin 19 [ Mus musculus (house mouse) ]

Gene ID: 16669, updated on 24-Jan-2023

Summary

Official Symbol
Krt19provided by MGI
Official Full Name
keratin 19provided by MGI
Primary source
MGI:MGI:96693
See related
Ensembl:ENSMUSG00000020911 AllianceGenome:MGI:96693
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
K19; CK-19; EndoC; Krt1-19; Krt-1.19
Summary
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Expression
Biased expression in colon adult (RPKM 2054.0), stomach adult (RPKM 1224.1) and 8 other tissues See more
Orthologs
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Genomic context

See Krt19 in Genome Data Viewer
Location:
11 D; 11 63.42 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100031636..100036752, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100140810..100145926, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene keratin 13 Neighboring gene keratin 15 Neighboring gene predicted gene, 39022 Neighboring gene keratin 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC25344

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of muscle ISO
Inferred from Sequence Orthology
more info
 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in costamere ISO
Inferred from Sequence Orthology
more info
 
part_of dystrophin-associated glycoprotein complex ISO
Inferred from Sequence Orthology
more info
 
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
located_in terminal web IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
keratin, type I cytoskeletal 19
Names
cytokeratin 19
keratin complex 1, acidic, gene 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313963.1NP_001300892.1  keratin, type I cytoskeletal 19 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate first exon in place of that of variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AB472075, AL590873
    UniProtKB/TrEMBL
    B1AQ78
    Related
    ENSMUST00000126460.8
    Conserved Domains (1) summary
    pfam00038
    Location:1189
    Filament; Intermediate filament protein
  2. NM_008471.3NP_032497.1  keratin, type I cytoskeletal 19 isoform 1

    See identical proteins and their annotated locations for NP_032497.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB472075, AL590873
    Consensus CDS
    CCDS25411.1
    UniProtKB/Swiss-Prot
    P19001
    UniProtKB/TrEMBL
    A0A8C6MNT3, B1AQ78
    Related
    ENSMUSP00000007317.8, ENSMUST00000007317.8
    Conserved Domains (3) summary
    cd00890
    Location:182307
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    pfam00038
    Location:82393
    Filament; Intermediate filament protein
    cl12013
    Location:247402
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100031636..100036752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)