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KRT15 keratin 15 [ Homo sapiens (human) ]

Gene ID: 3866, updated on 8-Jul-2021

Summary

Official Symbol
KRT15provided by HGNC
Official Full Name
keratin 15provided by HGNC
Primary source
HGNC:HGNC:6421
See related
Ensembl:ENSG00000171346 MIM:148030
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K15; CK15; K1CO
Summary
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 317.3), esophagus (RPKM 283.6) and 1 other tissue See more
Orthologs
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Genomic context

See KRT15 in Genome Data Viewer
Location:
17q21.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (41513745..41521924, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39669997..39675142, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 36 Neighboring gene keratin 13 Neighboring gene microRNA 6510 Neighboring gene keratin 19 Neighboring gene CRISPRi-validated cis-regulatory element chr17.2493

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in epidermis development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
keratin, type I cytoskeletal 15
Names
CK-15
cytokeratin 15
keratin 15, type I
keratin-15, basic
keratin-15, beta
type I cytoskeletal 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012284.1 RefSeqGene

    Range
    5001..10274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002275.4NP_002266.3  keratin, type I cytoskeletal 15

    Status: REVIEWED

    Source sequence(s)
    AC019349
    Consensus CDS
    CCDS11398.1
    Related
    ENSP00000254043.3, ENST00000254043.8
    Conserved Domains (1) summary
    pfam00038
    Location:104416
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    41513745..41521924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524784.3XP_011523086.1  keratin, type I cytoskeletal 15 isoform X1

    Conserved Domains (1) summary
    pfam00038
    Location:104423
    Filament; Intermediate filament protein
  2. XM_017024614.2XP_016880103.1  keratin, type I cytoskeletal 15 isoform X2

    Conserved Domains (1) summary
    pfam00038
    Location:104423
    Filament; Intermediate filament protein
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