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KRT15 keratin 15 [ Homo sapiens (human) ]

Gene ID: 3866, updated on 12-Aug-2018

Summary

Official Symbol
KRT15provided by HGNC
Official Full Name
keratin 15provided by HGNC
Primary source
HGNC:HGNC:6421
See related
Ensembl:ENSG00000171346 MIM:148030; Vega:OTTHUMG00000133435
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K15; CK15; K1CO
Summary
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 317.3), esophagus (RPKM 283.6) and 1 other tissue See more
Orthologs

Genomic context

See KRT15 in Genome Data Viewer
Location:
17q21.2
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (41513745..41521924, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39669997..39678033, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 36 Neighboring gene keratin 13 Neighboring gene microRNA 6510 Neighboring gene keratin 19 Neighboring gene long intergenic non-protein coding RNA 974

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Keratinization, organism-specific biosystem (from REACTOME)
    Keratinization, organism-specific biosystemKeratins are the major structural protein of vertebrate epidermis, constituting up to 85% of a fully differentiated keratinocyte (Fuchs 1995). Keratins belong to a superfamily of intermediate filamen...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cornification TAS
Traceable Author Statement
more info
 
cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
epidermis development TAS
Traceable Author Statement
more info
PubMed 
keratinization TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
intermediate filament IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 

General protein information

Preferred Names
keratin, type I cytoskeletal 15
Names
CK-15
cytokeratin 15
keratin 15, type I
keratin-15, basic
keratin-15, beta
type I cytoskeletal 15

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012284.1 RefSeqGene

    Range
    5001..10274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002275.3NP_002266.2  keratin, type I cytoskeletal 15

    See identical proteins and their annotated locations for NP_002266.2

    Status: REVIEWED

    Source sequence(s)
    AK122864, BC002641, BC110649
    Consensus CDS
    CCDS11398.1
    UniProtKB/Swiss-Prot
    P19012
    UniProtKB/TrEMBL
    B3KVF5
    Related
    ENSP00000254043.3, OTTHUMP00000164634, ENST00000254043.7, OTTHUMT00000257301
    Conserved Domains (1) summary
    pfam00038
    Location:104416
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    41513745..41521924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524784.3XP_011523086.1  keratin, type I cytoskeletal 15 isoform X1

    Conserved Domains (1) summary
    pfam00038
    Location:104423
    Filament; Intermediate filament protein
  2. XM_017024614.2XP_016880103.1  keratin, type I cytoskeletal 15 isoform X2

    Conserved Domains (1) summary
    pfam00038
    Location:104423
    Filament; Intermediate filament protein
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