Format

Send to:

Choose Destination

KPNA5 karyopherin subunit alpha 5 [ Homo sapiens (human) ]

Gene ID: 3841, updated on 7-Jun-2020

Summary

Official Symbol
KPNA5provided by HGNC
Official Full Name
karyopherin subunit alpha 5provided by HGNC
Primary source
HGNC:HGNC:6398
See related
Ensembl:ENSG00000196911 MIM:604545
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRP6; IPOA6
Summary
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 10.4), ovary (RPKM 8.3) and 24 other tissues See more
Orthologs

Genomic context

See KPNA5 in Genome Data Viewer
Location:
6q22.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (116677643..116741867)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (117002367..117063030)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene radial spoke head component 4A Neighboring gene zinc finger containing ubiquitin peptidase 1 Neighboring gene family with sequence similarity 162 member B Neighboring gene uncharacterized LOC105377963

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 NL4-3 replication requires KPNA5 as replication is inhibited when KPNA5 is deleted through CRISPR/Cas9 genome editing PubMed

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol HIV-1 IN interacts with importin alpha by the BiFC assay and amino acids 161-173 in IN are required for the interaction with importin alpha PubMed
gag-pol HIV-1 Rev disrupts both IN-TNPO3 and IN-importin alpha complexes PubMed
gag-pol Some reports indicate a possible role for the interactions between karyopherin alpha and beta with HIV-1 integrase in the nuclear import of HIV-1 preintegration complexes (PIC), while other reports indicate integrase is not involved in PIC nuclear import PubMed
gag-pol Karyopherin alpha binds to a bipartite nuclear localization signal in HIV-1 integrase (amino acids 186-189 and 211-219) PubMed
gag-pol Karyopherin alpha and beta are reported to interact with HIV-1 integrase (IN) to facilitate nuclear import of IN, however a conflicting report indicates nuclear accumulation of IN does not involve karyopherin alpha, beta 1, or beta 2 mediated pathways PubMed
matrix gag Nuclear import of HIV-1 preintegration complexes by karyopherin alpha is governed by phosphorylation of HIV-1 Matrix on tyrosine and serine, however the exact role of phosphorylation of the C-terminal tyrosine of Matrix has been debated PubMed
gag HIV-1 Matrix increases intracellular ATP content, an effect hypothesized to support the ATP-dependent nuclear import of HIV-1 preintegration complexes by karyopherin alpha PubMed
gag HIV-1 Vpr increases the affinity of karyopherin alpha to the HIV-1 Matrix nuclear localization signal, thereby mediating the nuclear import of HIV-1 preintegration complexes PubMed
gag Hsp70 stimulates the binding of HIV-1 matrix to karyopherin alpha PubMed
gag The role of HIV-1 Matrix during nuclear import of the HIV-1 preintegration complex has been controversial, however recent understanding indicates HIV-1 Matrix and Vpr proteins act in concert to facilitate nuclear import by binding to karyopherin alpha PubMed
gag HIV-1 Matrix contains two nuclear localization signals (NLS) spanning amino acids 24-33 and 110-114 that are recognized by karyopherin alpha and mediate the nuclear import of HIV-1 preintegration complexes PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear import signal receptor activity IEA
Inferred from Electronic Annotation
more info
 
nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
modulation by virus of host process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
host cell nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
importin subunit alpha-6
Names
importin alpha 6
karyopherin alpha 5 (importin alpha 6)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366304.1NP_001353233.1  importin subunit alpha-6 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AL132795, AL354716, KF458260
    Conserved Domains (2) summary
    sd00043
    Location:354386
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:56541
    Arm_3; Atypical Arm repeat
  2. NM_001366305.2NP_001353234.1  importin subunit alpha-6 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AL132795, AL354716, KF458260
    Conserved Domains (2) summary
    sd00043
    Location:354386
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:56541
    Arm_3; Atypical Arm repeat
  3. NM_001366306.2NP_001353235.1  importin subunit alpha-6 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variant 3, encodes isoform b.
    Source sequence(s)
    AL132795, AL354716, KF458260
    Related
    ENSP00000357552.1, ENST00000368564.7
    Conserved Domains (2) summary
    sd00043
    Location:334366
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:36521
    Arm_3; Atypical Arm repeat
  4. NM_001366307.2NP_001353236.1  importin subunit alpha-6 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL132795, AL354716, KF458260
    Conserved Domains (2) summary
    sd00043
    Location:331363
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:33518
    Arm_3; Atypical Arm repeat
  5. NM_001366308.1NP_001353237.1  importin subunit alpha-6 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL132795, AL354716, KF458260
    Conserved Domains (2) summary
    sd00043
    Location:334366
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:36476
    Arm_3; Atypical Arm repeat
  6. NM_001366309.2NP_001353238.1  importin subunit alpha-6 isoform e

    Status: REVIEWED

    Source sequence(s)
    AL132795
    Conserved Domains (2) summary
    sd00043
    Location:142175
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:56327
    Arm_3; Atypical Arm repeat
  7. NM_001366310.2NP_001353239.1  importin subunit alpha-6 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL132795
    Conserved Domains (2) summary
    sd00043
    Location:122155
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:36307
    Arm_3; Atypical Arm repeat
  8. NM_002269.3NP_002260.2  importin subunit alpha-6 isoform b

    See identical proteins and their annotated locations for NP_002260.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variant 4, encodes isoform b.
    Source sequence(s)
    AA332147, BC047409, BG721781
    Consensus CDS
    CCDS5111.1
    UniProtKB/Swiss-Prot
    O15131
    Related
    ENSP00000348704.1, ENST00000356348.6
    Conserved Domains (2) summary
    sd00043
    Location:334366
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:36521
    Arm_3; Atypical Arm repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    116677643..116741867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446427.1XP_024302195.1  importin subunit alpha-6 isoform X5

    Conserved Domains (2) summary
    sd00043
    Location:122154
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:6309
    Arm_3; Atypical Arm repeat
  2. XM_024446426.1XP_024302194.1  importin subunit alpha-6 isoform X5

    Conserved Domains (2) summary
    sd00043
    Location:122154
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:6309
    Arm_3; Atypical Arm repeat
  3. XM_017010841.2XP_016866330.1  importin subunit alpha-6 isoform X4

    Conserved Domains (4) summary
    cd00020
    Location:47161
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam16186
    Location:260304
    Arm_3; Atypical Arm repeat
    sd00044
    Location:832
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:127159
    ARM; armadillo repeat [structural motif]
Support Center